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Filtered Search Results
Medchemexpress LLC Sudan I (Solvent Yellow 14) | 842-07-9 | 99.8% | 25 G
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Sudan I (Solvent Yellow 14) is a diazo-conjugate red dye that can be used as an additive to products such as oils, solvents, or polishes. It inhibits the growth of bacterial strains Clostridium perfringens and L. rhamnosus. Sudan I is a monoazo dye with the chemical formula of 1-phenylazo-2-naphthol. It can cause tumors in the liver or urinary bladder in mammals and is considered a potential mutagen and carcinogen for humans. It induces genotoxic effects in HepG2 cells and increases mutagenic and clastogenic effects in MCL-5 cell lines compared to AHH-1 cell lines. Additionally, Sudan I yields positive results in Salmonella Typhimurium mutagenicity tests with S9 activation.
- Diazo-conjugate red dye
- Can be used as an additive to products like oils, solvents, or polishes
- Inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus
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Apexbio Technology LLC Carfilzomib (PR-171) 868540-17-4 10mg
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Carfilzomib (PR-171 CAS 868540-17-4) is a derivative of the natural product epoxomicin and functions as an irreversible inhibitor of the chymotrypsin-like activity within the 20S proteasome Proteasomes play a critical role in intracellular protein degradation thus inhibition results in accumulation of polyubiquitinated proteins Through this mechanism Carfilzomib induces cell cycle arrest and apoptosis consequently suppressing tumor cell growth Research applications primarily involve exploration of its antitumor efficacy and mechanisms in oncology models
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Medchemexpress LLC 2-Methylanisole | 578-58-5 | MFCD00008373 | 99.8% | 122.17 g/mol | C8H10O | 50 G
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2-Methylanisole is a monomethoxybenzene used as a chemical intermediate in the preparation of compounds containing a methylhydroquinone core. It is supplied as a high-purity liquid in multiple pack sizes for research and synthetic applications.
- High purity (99.8%).
- Molecular weight 122.17 g/mol.
- Molecular formula C8H10O.
- Suitable as a chemical intermediate for organic synthesis.
- Supplied as a liquid in multiple pack sizes, including 50 g.
- Supporting documentation available: datasheet, SDS, COA.
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Apexbio Technology LLC PKH67 Green Fluorescent Cell Linker Kit(Synonyms: PKH67 Cell Labeling Kit, PKH67 Fluorescent Dye Kit, PKH67 Green Fluorescent Cell Dye), 2500T.
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PKH67 Green Fluorescent Cell Linker Kit is designed for fluorescent labeling of cell membranes The kit utilizes the green fluorescent probe PKH67 a lipophilic dye that integrates stably into lipid regions of the plasma membrane emitting bright green fluorescence Upon cell division PKH67 distributes evenly among progeny cells causing fluorescence intensity to diminish incrementally with cell proliferation Due to its stability low cytotoxicity and minimal staining of adjacent cells PKH67 is widely applied in vitro and in vivo for tracking cell migration localization and monitoring cell proliferation dynamics Additionally PKH67 can be combined with other fluorescent dyes such as PKH26 for multiplex cell-labeling studies
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Medchemexpress LLC KX-01-191 | 2211903-84-1 | 99.87% | 1 ML
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KX-01-191 (compound 5c′) is a tin-precursor primarily for research use only. It appears as a solid with a white to off-white color. Its molecular weight is 552.34 and its chemical formula is C28H39N3OSn.
- Molecular weight: 552.34
- Formula: C28H39N3OSn
- Appearance: Solid
- Color: White to off-white
- Solubility in DMSO: ≥ 100 mg/mL (181.05 mM)
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Medchemexpress LLC Eprodisate (70% in water) | 21668-77-9 | 98.0% | 1 ML
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Eprodisate (70% in water) is an amyloid inhibitor that interferes with the interaction between amyloidogenic proteins and glycosaminoglycans. It is intended for research use only.
- Inhibits aggregation of amyloid fibrils
- Inhibits deposition of fibrils in tissues
- Slows progression of renal disease associated with AA amyloidosis
- May be useful for other types of amyloidosis
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Medchemexpress LLC E-7386 | 1799824-08-0 | 99.11% | 725.85 | 50 MG
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E-7386 is an orally active CBP/beta-catenin modulator. It can induce T cell infiltration into tumors and enhance the antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice models. It demonstrates significant antitumor activity in the Wnt1 model, with clear T cell infiltration into tumors observed in the treatment group compared to the limited infiltration in the vehicle control group.
- Orally active CBP/beta-catenin modulator.
- Induces T cell infiltration into tumors.
- Enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice models.
- Shows significant antitumor activity in Wnt1 models.
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Medchemexpress LLC Ethambutol dihydrochloride | 1070-11-7 | 99.9% | 1 G
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Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. It can be used to establish animal models of hyperuricemia and optic neuropathy.
- Antimycobacterial compound
- Prevents cell wall formation
- Inhibits arabinosyltransferase activity
- Useful for establishing animal models of hyperuricemia and optic neuropathy
- For research use only
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Medchemexpress LLC Dibenzothiophene | 132-65-0 | MFCD00004969 | 99.9% | 25 G
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Dibenzothiophene is an orally active and noncompetitive CYP1A inhibitor, primarily used for studying developmental toxicity mechanisms. It inhibits CYP1A-mediated EROD activity with a Km of 0.592 μM and interacts with the AHR pathway. This compound enhances the embryotoxicity of β-naphthoflavone and shows acute toxicity in mice.
- Orally active and noncompetitive CYP1A inhibitor
- Inhibits CYP1A-mediated EROD activity
- Interacts with the AHR pathway
- Enhances embryotoxicity of β-naphthoflavone
- Used for studying mechanisms of developmental toxicity
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Medchemexpress LLC Nizatidine | 76963-41-2 | 98.7% | 25 G
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Nizatidine is a potent and orally active histamine H2 receptor antagonist. It is used in research for stomach and intestine ulcers, functioning by decreasing gastric acid secretion and preventing ulcer recurrence in animal models.
- Potent and orally active histamine H2 receptor antagonist
- Decreases gastric acid secretion
- Prevents ulcer recurrence after healing in animal models
- Molecular weight: 331.46
- Formula: C12H21N5O2S2
- Appearance: Solid
- Color: White to off-white
- Recommended storage for powder: -20°C for 3 years, 4°C for 2 years
- Recommended storage in solvent: -80°C for 2 years, -20°C for 1 year
- Melting/freezing point: 130–132°C
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Medchemexpress LLC Betaine | 107-43-7 | 99.8% | 100 G
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Betaine (Trimethylglycine) is a natural compound and active methyl-donor that helps maintain normal DNA methylation patterns. Found ubiquitously in plants, animals, and microorganisms, it acts as an osmolyte, regulating cellular water and ion balance. This compound supports various intestinal microbes and has demonstrated inhibition of HeLa cell proliferation in vitro, as well as attenuation of liver-to-body weight ratio in vivo.
- Maintains normal DNA methylation patterns.
- Regulates cellular water and ion balance.
- Improves capacity against heat stress.
- Promotes intestinal microbial fermentation activity.
- Inhibits proliferation of HeLa cells (in vitro).
- Attenuates liver-to-body weight ratio (in vivo).
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Medchemexpress LLC Cyanoacetohydrazide | 140-87-4 | 99.7% | 25 G
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Cyanoacetohydrazide is a pharmaceutical intermediate. It can be used to synthesize acylhydrazide hydrazone derivatives with antibacterial or anti-tumor activity.
- Molecular weight of 99.09
- Chemical formula: C3H5N3O
- Appears as a solid
- Color ranges from light yellow to light brown
- Solid storage at 4°C, sealed, away from moisture
- Solvent storage at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture
- Soluble in DMSO at 100 mg/mL
- Soluble in water at 100 mg/mL
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Medchemexpress LLC MSX-122 | 897657-95-3 | 98.2% | 292.34 | 1 ML
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MSX-122 is an orally active partial antagonist of CXCR4, inhibiting CXCR4/CXCL12 actions with an IC50 of approximately 10 nM. This compound demonstrates anti-inflammatory and anti-metastatic activity. It is intended for research use only.
- Orally active partial antagonist of CXCR4
- Inhibits CXCR4/CXCL12 actions
- Exhibits anti-inflammatory activity
- Exhibits anti-metastatic activity
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Medchemexpress LLC Pregnenolone (3β-Hydroxy-5-pregnen-20-one) | 145-13-1 | >99.9% | 25 G
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Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a potent neurosteroid and the primary precursor for various steroid hormones, including steroid ketones. It functions as a signaling-specific inhibitor of the cannabinoid CB1 receptor, thereby inhibiting the effects of tetrahydrocannabinol (THC) that are mediated by CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Additionally, it acts as a TRPM3 channel activator and can weakly activate TRPM1 channels.
- Potent neurosteroid
- Primary precursor for various steroid hormones
- Signaling-specific inhibitor of CB1 receptor
- Inhibits THC effects mediated by CB1 receptors
- Protects the brain from cannabis intoxication
- Acts as a TRPM3 channel activator
- Weakly activates TRPM1 channels
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Medchemexpress LLC 1,2-Benzisothiazole, 3-(1-piperazinyl)- | 87691-87-0 | 99.96% | 219.31 | 100 G
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Antidepressant agent 10 (Compound 4) is an orally active compound. It has IC50 values of 190 nM for 5-HT1A and 110 nM for 5-HT2. It can be used in the research of mental disorders.
- Orally active compound.
- Can be used in the research of mental disorders.
- Also available as an analytical standard intended for research and analytical applications.
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