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Filtered Search Results
Medchemexpress LLC Bromoacetamido-C2-PEG2-NH-Boc | 182244-33-3 | C13H25BrN2O5 | 5 G
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Bromoacetamido-C2-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC Zika virus envelope (E) protein | >90.0% | 100 UG
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Recombinant Zika virus envelope (E) protein, full-length (438 amino acids), produced in Sf9 insect cells with a C-terminal His tag. Supplied as a 0.22 μm filtered buffered solution (20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0) for research use only. Purity is reported as greater than 90% by reducing SDS-PAGE. Store at -80°C, aliquot to avoid repeated freeze-thaw cycles.
- Recombinant full-length envelope protein (438 a.a.).
- Expressed in Sf9 insect cells for eukaryotic processing.
- C-terminal His tag facilitates purification and detection.
- Supplied in a ready-to-use buffered formulation.
- Purity greater than 90% as determined by reducing SDS-PAGE.
- Suitable for immunoassays, antibody production, and biochemical characterization.
- Store at -80°C; avoid repeated freeze-thaw cycles.
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Medchemexpress LLC C.I. Basic red 14 | 12217-48-0 | 99.09% | 25 G
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C.I. Basic red 14 is an alkaline dye that can be removed from aqueous solutions in intermittent adsorption systems using tree ferns as biosorbents. It is for research use only.
- Functions as an alkaline dye
- Can be removed from aqueous solutions using biosorbents
- Suitable for research applications
- Categorized as a fluorescent dye
- Used in labeling chemistry
- Functions as a chemical stain
- Utilized as an analysis chemical
- Belongs to analytical dyes classification
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Medchemexpress LLC Guaiacol | 90-05-1 | 124.14 | 100 G
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Guaiacol, also known as 2-Methoxyphenol, is a phenolic compound exhibiting anti-inflammatory activity. It is known to inhibit LPS-stimulated COX-2 expression and NF-κB activation, with an IC50 for COX-2 and NF-κB. This compound also demonstrates antiproliferative activity against human U251MG and U87MG cells.
- Inhibits LPS-stimulated NF-κB activation and COX-2 gene expression
- Exhibits anti-inflammatory properties
- Shows antiproliferative activity against U-251 and U-87MG human cell lines
- Soluble in DMSO (≥ 100 mg/mL) and water (37.5 mg/mL)
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Medchemexpress LLC (R)-BPO-27 | 1415390-47-4 | 99.9% | 548.34 | 1 ML
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(R)-BPO-27 is a potent, orally active, and ATP-competitive CFTR inhibitor with an IC50 of 4 nM. It is the R enantiomer of BPO-27, acting from the cytoplasmic side with low membrane permeability. This compound reduces channel open probability and increases mean channel closed time in HEK-293T cells expressing human wild-type CFTR, and is intended for research use only.
- Potent CFTR inhibitor with an IC50 of 4 nM
- Stabilizes CFTR channel closed state at 600 pM
- Effective in inhibiting Cl- current stimulated by cAMP and cGMP agonists
- Provides sustained therapeutic concentrations in the kidney
- Prevents cholera toxin-induced fluid accumulation in intestinal loops
- Achieves approximately 94% oral bioavailability in mice
- Exhibits slow metabolism, maintaining serum levels for over 4 hours
- Shows efficacy in mouse models of cholera and traveler's diarrhea
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Medchemexpress LLC (R)-(+)-tert-Butylsulfinamide | 196929-78-9 | 100.0% | 121.20 | 25 G
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(R)-(+)-tert-Butylsulfinamide is a chiral reagent commonly used in the asymmetric synthesis of compounds such as amines, amino acids, and amino alcohols. It achieves stereoselective reactions by condensing with carbonyl groups to form sulfinyl imine intermediates, which can then be removed under acidic conditions to obtain the target product.
- Chiral reagent for asymmetric synthesis.
- Used in the synthesis of amines, amino acids, and amino alcohols.
- Achieves stereoselective reactions.
- Participates in cycloaddition and cyclization reactions of enynes and diynes through asymmetric induction, N-alkylation, and deprotection or oxidation under mild conditions to construct polycyclic scaffold libraries related to alkaloid and terpenoid natural products.
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Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | 99.6% | C21H28ClN5 | 100 MG
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Mavorixafor hydrochloride (AMD-070) is a potent, selective, and orally available CXCR4 antagonist with an IC50 value of 13 nM against CXCR4 125I-SDF binding. It also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with IC50 values of 1 nM and 9 nM, respectively. This compound can be used for the study of WHIM syndrome.
- Potent and selective CXCR4 antagonist.
- Orally available.
- Inhibits replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
- Used for the study of WHIM syndrome.
- Shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2).
- Significantly suppresses anchorage-dependent growth of B88-SDF-1 cells.
- Impairs motility and inhibits migration and Matrigel invasion of B88-SDF-1 cells.
- Inhibits lung metastasis of B88 SDF 1 cells in nude mice.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000691891 PYRAZINAMIDE 500G
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Cell Signaling Technology CELL SIGNALING TECHNOLOGY INC
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5000559632 PHOSPHO-ZAP-70 TYR319/SYK TYR3
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Cell Signaling Technology CELL SIGNALING TECHNOLOGY INC
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5000561104 E-CADHERIN 24E10 RABBIT MAB SI
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Cell Signaling Technology CELL SIGNALING TECHNOLOGY INC
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5000561477 TOTAL TFEB MATCHED ANTIBODY PA
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Medchemexpress LLC DNA, d(P-thio)(C-G-G-C-A-T-G-T-C-T-A-T-T-T-T-G-T-A), sodium salt | 871479-94-6 | 98.8% | C177H217N60Na18O94P17S17 | 1 MG
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Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits Transforming Growth Factor-beta 2 (TGF-β2). This inhibition makes it a candidate for studying malignant brain tumors and other solid tumors that overexpress TGF-β2, including those found in the skin, pancreas, and colon. It works by interfering with the expression of the TGF-β2 gene.
- Specifically inhibits TGF-β2
- Candidate for studying malignant brain tumors
- Candidate for studying solid tumors overexpressing TGF-β2
- Available as a solid, white to off-white in color
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Medchemexpress LLC Almotriptan hydroch | 5MG
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Almotriptan hydroch | 5MG
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Medchemexpress LLC 2-Chloro-N- methylsu 25g | 25G
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2-Chloro-N- methylsu 25g | 25G
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Medchemexpress LLC Carbamodithioic acid, N,N-diethyl-, sodium salt (1:1) | 148-18-5 | 99.2% | 25 G
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Ditiocarb sodium is an orally active copper reagent known for its diverse activities, including antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. This compound is valuable for research in various fields such as tumors, inflammatory, and immune-related diseases.
- Exhibits antioxidation and chelation activities.
- Shows anti-tumor effects.
- Provides immunomodulation.
- Possesses anti-HIV properties.
- Suitable for research on tumors.
- Useful in studies of inflammatory diseases.
- Applied in research on immune-related diseases.
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