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Filtered Search Results
Medchemexpress LLC Azure II | 37247-10-2 | 25 G
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Azure II is a dye primarily used for nuclear staining. This product is suitable for various laboratory applications requiring precise cellular visualization.
- Utilized as a nuclear stain
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Medchemexpress LLC RG-6125 1mg | 1mg
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RG-6125 is a humanized antibody expressed in CHO targeting CDH11/Cadherin-11 RG-6125 has a huIgG2 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 kDa The isotype control for RG-6125 can refer to Human IgG2 kappa Isotype Control (HY-P99002)
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Medchemexpress LLC RGLS4326 sodium | 99.7% | 3082.42 (free acid) | 1 MG
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RGLS4326 sodium is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). It can be used for the research of autosomal dominant polycystic kidney disease (ADPKD).
- First-in-class short oligonucleotide inhibitor
- Inhibits microRNA-17 (miR-17)
- Used for research of autosomal dominant polycystic kidney disease (ADPKD)
- Inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM
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Medchemexpress LLC Bis-PEG23-endo-BCN | ≥98.0% | 1425.73 | 25 MG
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Bis-PEG23-endo-BCN is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a BCN group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- PEG-based PROTAC linker
- Used for synthesis of PROTACs
- Click chemistry reagent
- Features a BCN group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- For research use only
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Medchemexpress LLC PKR-IN-C16 | 608512-97-6 | 99.7% | 268.29 | 1 MG
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PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. It exhibits promising neuroprotective properties, can rescue acute brain lesions, and helps unlock translation blockade induced by PKR in primary neuronal cultures.
- Specific double-stranded RNA-dependent protein kinase (PKR) inhibitor
- Exhibits neuroprotective properties
- Rescues acute brain lesions
- Protects against neuronal cell death induced by endoplasmic reticulum stress
- Prevents PKR-phosphorylation and activation of caspase-3
- Reduces phosphorylated PKR levels
- Prevents PKR-induced neuronal loss and inflammatory response
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Medchemexpress LLC Ethanol, 2,2'-oxybis-, 1,1'-dimethanesulfonate | 34604-52-9 | 97.0% | C6H14O7S2 | 25 G
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Ms-PEG2-MS is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. PROTACs are compounds that contain two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins, offering a promising approach for targeted therapy.
- Purity of 97.0%
- Off-white to light yellow solid appearance
- Molecular weight of 262.30
- Chemical formula C6H14O7S2
- Used in the synthesis of PROTACs
- CAS number 34604-52-9
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Medchemexpress LLC Bis-aminooxy-PEG2 | 98627-71-5 | MFCD00519242 | 95% | C6H16N2O4 | 100 MG
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Bis-aminooxy-PEG2 is a PEG-based PROTAC linker used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker
- One ligand is for an E3 ubiquitin ligase
- The other ligand is for the target protein
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrade target proteins
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Medchemexpress LLC Bromo-PEG6-azide | 2062663-64-1 | 95.0% | C14H28BrN3O6 | 100 MG
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Bromo-PEG6-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, possessing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
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Medchemexpress LLC PR-104A | 680199-06-8 | 99.0% | C14H19BrN4O9S | 1 ML
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PR-104A (SN 27858) is the alcohol metabolite of the phosphate proagent PR-104. It functions as a hypoxia-selective DNA cross-linking and damaging agent and cytotoxin with antitumor activity. It undergoes metabolism under hypoxic conditions via the 1-electron NADPH:cytochrome P450 oxidoreductase and is utilized in research concerning relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL).
- Functions as a hypoxia-selective DNA cross-linking agent
- Acts as a DNA-damaging agent and cytotoxin
- Exhibits antitumor activity
- Undergoes metabolism under hypoxic conditions via 1-electron NADPH:cytochrome P450 oxidoreductase
- Utilized in research concerning relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL)
- For research use only
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Medchemexpress LLC Drisapersen sodium | 1181666-20-5 | 98.6% | C211H256N76Na19O119P19S19 | 1 MG
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Drisapersen sodium is an antisense oligonucleotide that induces exon 51 skipping during dystrophin pre-mRNA splicing, leading to the synthesis of partially functional dystrophin in Duchenne muscular dystrophy (DMD) patients with amenable mutations. It is intended for research use only.
- Induces exon 51 skipping during dystrophin pre-mRNA splicing
- Allows for synthesis of partially functional dystrophin
- Suitable for Duchenne muscular dystrophy (DMD) research
- For research use only
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Medchemexpress LLC SN-008 | 2249106-01-0 | 99.68% | C25H19FN2O3S | 1 ML
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SN-008 is a less active analog of SN-011 and can be utilized as a negative control. It is intended for research use only.
- Less active analog of SN-011
- Can be utilized as a negative control
- Intended for research use only
- High purity of 99.68%
- Molecular weight of 446.49
- Appears as a white to off-white solid
- Soluble in DMSO
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Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59ClN8O8S2 | 1 ML
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OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells. It is for research use only.
- Shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively
- Demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells
- Targets BRD4, BRD2, BRD3, and VHL
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Medchemexpress LLC Bromo-PEG1-C2-azide | 1144106-65-9 | 99.5% | C4H8BrN3O | 25MG
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Bromo-PEG1-C2-azide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. It can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Utilizes the intracellular ubiquitin-proteasome system
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Medchemexpress LLC OARV-771 | 2683008-37-7 | 98.77% | C49H59CIN8O8S2 | 100 MG
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OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. It demonstrates an antiproliferative effect with an EC50 value of 4 nM in MV4;11 cells.
- Exhibits DC50 values of 6 nM for Brd4, 1 nM for Brd2, and 4 nM for Brd3.
- Improved cell permeability.
- Shows antiproliferative effect in MV4;11 cells.
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Medchemexpress LLC BSJ-02-162 | 2139329-47-6 | 98.1% | C43H49N11O7 | 1 ML
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BSJ-02-162, also known as CDK4/6-IN-11, is a potent PROTAC CDK4/6 degrader. It is specifically designed with a thalidomide-based E3 ligase ligand, Palbociclib as a target protein ligand, and a PROTAC linker, making it suitable for targeted protein degradation studies.
- Potent PROTAC CDK4/6 degrader
- Composed of a thalidomide-based E3 ligase ligand
- Includes a target protein ligand
- Features a PROTAC linker
- Available in solid and solution formats
- Soluble in DMSO
- Store powder at -20°C for 3 years, 4°C for 2 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month
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