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8-CPT-2Me-cAMP sodium salt (CAS 634207-53-7) is a selective agonist of exchange proteins directly activated by cAMP (EPACs) which are key intracellular cAMP sensors acting as guanine nucleotide exchange factors for Rap1 and Rap2 This compound effectively activates EPAC1 leading to increased Rap1 activity and enhanced cell adhesion particularly in the presence of MAP1A light chain 2 In Jurkat T cells 8-CPT-2Me-cAMP induces Rap1 activation independently of PKA inhibition In prostate cancer cell models it dose-dependently upregulates Epac1 phosphorylated Akt and stimulates mTORC1/mTORC2 signaling It is widely utilized to dissect EPAC-specific pathways in cell signaling adhesion and proliferation studies
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
8-CPT-2Me-cAMP sodium salt (CAS 634207-53-7) is a selective agonist of exchange proteins directly activated by cAMP (EPACs) which are key intracellular cAMP sensors acting as guanine nucleotide exchange factors for Rap1 and Rap2 This compound effectively activates EPAC1 leading to increased Rap1 activity and enhanced cell adhesion particularly in the presence of MAP1A light chain 2 In Jurkat T cells 8-CPT-2Me-cAMP induces Rap1 activation independently of PKA inhibition In prostate cancer cell models it dose-dependently upregulates Epac1 phosphorylated Akt and stimulates mTORC1/mTORC2 signaling It is widely utilized to dissect EPAC-specific pathways in cell signaling adhesion and proliferation studies
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More