Fumonisins
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Medchemexpress LLC Avermectin B1 | 71751-41-2 | C48H72O14 | 10 MM 1 ML
Avermectin B1 (Abamectin) is a mixture of two similar segments of avermectin. It is an orally active anti-infection agent used in the research of parasitic worms, insect pests, agriculture, and animal husbandry. Avermectin B1 can also induce the production of reactive oxygen species (ROS) and leads to cytotoxicity, apoptosis, and autophagy.
- Acts as an orally active anti-infection agent
- Induces reactive oxygen species (ROS) production
- Leads to cytotoxicity, apoptosis, and autophagy
- Effective against intestinal strongyles and Onchocera microfilaria
- Shows nematicidal effect on G. pallida
- Induces cytotoxicity through MAPK and ATM/ATR pathways
- Inhibits ROS-mediated PI3K/AKT signaling, leading to apoptosis and autophagy
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Medchemexpress LLC Procyanidin B1 | 20315-25-7 | 578.52 | 1 MG
Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits. It binds to the TLR4/MD-2 complex and exhibits anti-inflammatory activity. It is for research use only.
- Polyphenolic flavonoid isolated from fruits and fruit juices
- Binds to TLR4/MD-2 complex
- Possesses anti-inflammatory activity
- Causes cellular toxicity at concentrations >100 μg/mL
- Inhibits LPS-induced TNF-α production and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK, and NF-κB protein in THP1 cells at 100 μg/mL
- Protects against Aβ oligomer-induced neuronal death at 50-100 μM
- Potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at 30, 50, and 100 μM, and caspase-9 at 10, 30, 50, and 100 μM
- Significantly and dose-dependently induces expression of ACO and CPT1 at 10, 20, 30 μM, with no obvious effect on mRNA expression of PPARα