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Organic compounds that contain three carboxyl groups; carboxyl groups consist of a carbonyl group bonded to a hydroxy group. Includes compounds that are derived from tricarboxylic acids.
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Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTAC. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Used as a PEG-based PROTAC linker
Suitable for PROTAC synthesis
Utilizes the intracellular ubiquitin-proteasome system
Selectively degrades target proteins
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