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Filtered Search Results
Medchemexpress LLC Ym-244769 (hydrochloride) | 837424-39-2 | MFCD31561984 | 99.0% | 479.93 g/mol | C26H23ClFN3O3 | 50 MG
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YM-244769 hydrochloride is a potent, selective inhibitor of the Na+/Ca2+ exchanger (NCX) supplied as a high-purity research chemical for pharmacological and physiological studies. The product is provided as a hydrochloride salt in powder form and is used in cardiovascular and neurological research to probe NCX-mediated transport and signaling.
- Potent, selective inhibition of Na+/Ca2+ exchanger for NCX studies.
- High purity suitable for in vitro and in vivo research.
- Provided as a stable hydrochloride salt for reproducible dosing.
- Supplied as a powder for flexible formulation and storage.
- Documented certificate of analysis and safety data sheet available for quality assurance.
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Medchemexpress LLC Upacicalcet sodium | 2052969-18-1 | 99.9% | 373.75 | 1 ML
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Upacicalcet sodium is a non-peptide calcimimetic agent that functions as a calcium-sensing receptor (CaSR) agonist. It is used in secondary hyperparathyroidism (SHPT) research due to its ability to decrease serum intact parathyroid hormone (iPTH) and calcium (Ca2+) levels, which helps reduce hypocalcemia and gastrointestinal complications. This compound also improves vascular calcification and bone disorders in models of adenine-induced SHPT and inhibits cortical pore formation and bone fibrosis in rats with chronic kidney disease (CKD).
- Functions as a CaSR agonist (EC50 = 10.8 nM)
- Increases intracellular Ca2+ and IP-1 in human CaSR-expressing cells
- Reduces serum iPTH, Ca2+, and Pi levels in rats
- Inhibits parathyroid hyperplasia in CKD rat models
- Inhibits ectopic calcification and cortical hole formation in CKD rat models
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eMolecules 25743-12-8 | NH-bis(PEG2-OH) | Broadpharm | MFCD29764330 | 281.349 | C12H27NO6 | 98.000 | OCCOCCOCCNCCOCCOCCO | 1g | 303671216
NH-bis(PEG2-OH) | Broadpharm | 25743-12-8 | MFCD29764330 | 281.349 | C12H27NO6 | 98.000 | OCCOCCOCCNCCOCCOCCO | 1g | 303671216
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eMolecules 6160-65-2 | Thiocarbonyldiimidazole | ChemScene | MFCD00005289 | 178.210 | C7H6N4S | 98.000 | S=C(n1ccnc1)n1ccnc1 | 20g | 894453299
Thiocarbonyldiimidazole | ChemScene | 6160-65-2 | MFCD00005289 | 178.210 | C7H6N4S | 98.000 | S=C(n1ccnc1)n1ccnc1 | 20g | 894453299
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Medchemexpress LLC 3 -O-METHYLGUANOSINE 50MG
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5000208634 3 -O-METHYLGUANOSINE 50MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000297794 CONTEZOLID 10MG
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eMolecules 2598242-66-9 | Medchem Express | NG-497 | 5mg | 785215391 | HY-148756 | 315.369 | C18H21NO4
ChemScene | 4-Oxo-24-diphenylbutanenitrile | 250mg | 687374856 | CS-0322781 | 6268-00-4 | MFCD00019807 | 235.286 | C16H13NO
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eMolecules 155270-99-8 | Medchem Express | Istradefylline | 10mg | 446259409 | HY-10888 | MFCD00928421 | 384.436 | C20H24N4O4
ChemScene | 6-Bromothieno[32-d]pyrimidin-4(3H)-one | 100mg | 712788015 | CS-0360977 | 215927-36-9 | MFCD17677443 | 231.070 | C6H3BrN2OS
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Medchemexpress LLC HY-101938 1mg Medchemexpress, Sinefungin CAS:58944-73-3 Purity:>98%
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Medchemexpress, HY-101938 1mg Sinefungin CAS:58944-73-3 Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC M-89 | 2363165-42-6 | 99.1% | 10 MG
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M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to study MLL leukemia. M-89 inhibits the cell growth in leukemia cell lines carrying MLL fusion.
- Inhibits the cell growth of MV4-11 cell line with an IC50 of 25 nM.
- Inhibits the cell growth of HL-60 cell line with an IC50 of 10.2 μM.
- Stabilized the cellular menin protein in both MV4-11 and MOLM-13 cells dose-dependently (3.7-300 nM).
- Induces a time- and dose-dependent apoptosis in MV4-11 cells (0.03-3 μM, 48 h).
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Medchemexpress LLC DiABZI-C2-NH2 | 2137975-93-8 | 96.14% | 721.81 | 100 MG
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diABZI-C2-NH2 is an active analogue containing a primary amine functionality and acts as a STING agonist. It has shown strong anti-tumor activity in immunocompetent mice with syngeneic colon tumors, leading to complete and lasting regression of tumors. This compound can be covalently immobilized on sepharose beads for affinity-capture of potential target proteins from THP1 cell lysate.
- Functions as a STING agonist
- Exhibits strong anti-tumor activity in immunocompetent mice
- Leads to complete and lasting regression of tumors
- Can be covalently immobilized on sepharose beads
- Useful for affinity-capture of potential target proteins from THP1 cell lysate
- Enhanced binding to STING and cellular function
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Medchemexpress LLC YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 50 MG
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YM-244769 dihydrochloride is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode). This compound efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage and increases urine volume and urinary excretion of electrolytes in mice.
- Potent and selective Na+/Ca2+ exchanger (NCX) inhibitor
- Preferentially inhibits NCX3 with an IC50 of 18 nM
- Suppresses unidirectional outward NCX current (Ca2+ entry mode)
- Protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage
- Increases urine volume and urinary excretion of electrolytes in mice
- Also inhibits NCX1 (IC50: 68 nM) and NCX2 (IC50: 96 nM)
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Medchemexpress LLC Ym-244769 dihydrochloride | 1780390-65-9 | MFCD28160863 | ≥98.0% | C26H22FN3O3·2HCl | 10MG
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YM-244769 dihydrochloride is a research reagent that potently and selectively inhibits the Na+/Ca2+ exchanger (NCX). Supplied as the dihydrochloride salt, it is intended for cellular and biochemical studies probing NCX function.
- Potent, selective Na+/Ca2+ exchanger (NCX) inhibitor.
- Supplied as the dihydrochloride salt for improved solubility.
- Suitable for cellular and biochemical assays.
- High purity (≥98.0% by HPLC).
- Characterized with CAS 1780390-65-9 for unambiguous identification.
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Medchemexpress LLC YM-244769 dihydrochloride | 1780390-65-9 | 516.39 | 100 MG
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YM-244769 dihydrochloride is a potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor. It preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode). This compound efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
- Potent, selective, and orally active Na+/Ca2+ exchanger (NCX) inhibitor
- Preferentially inhibits NCX3
- Suppresses unidirectional outward NCX current (Ca2+ entry mode) with IC50s of 18 nM and 50 nM
- Efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage
- Increases urine volume and urinary excretion of electrolytes in mice
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eMolecules 1802088-50-1 | Medchem Express | NCT-501 | 5mg | 446269434 | HY-18768 | MFCD29472261 | 416.526 | C21H32N6O3
AstaTech | ETHYL 2-(2-PIPERIDYL)ACETATE | 0.25g | 256638514 | 30366 | 95.000 | 2739-99-3 | MFCD09752674 | 171.240 | C9H17NO2
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