Oxazoles
Medchemexpress LLC (4S)-GLP-1 receptor agonist 14 | 2758659-09-3 | 99.6% | 880.94 | 5 MG
(4S)-GLP-1 receptor agonist 14 is a potent and orally active GLP-1 receptor agonist with an EC50 ≤ 20 nM. It is intended for research applications related to diabetes, obesity, metabolic diseases, cardiovascular diseases, liver diseases, and nonalcoholic steatohepatitis (NASH), as well as other conditions associated with the GLP-1 receptor. In vitro, it inhibits OATP1B1 with an IC50 < 1 μM in HEK293 cells. In vivo, a single oral dose at 5 mg/kg in rats demonstrates good pharmacokinetic parameters, with a Cmax of 1700 ng/mL, AUC of 10193 ng·h/mL, and an oral bioavailability (F) of 90%.
- Potent and orally active GLP-1 receptor agonist
- EC50 ≤ 20 nM
- Inhibits OATP1B1 with an IC50 < 1 μM in HEK293 cells
- Exhibits good pharmacokinetic parameters in rats
- Suitable for research on diabetes, obesity, metabolic diseases, cardiovascular diseases, liver diseases, and nonalcoholic steatohepatitis (NASH)
Medchemexpress LLC (4S)-PROTAC SOS1 degrader-1 | 2913176-81-3 | C57H76ClFN10O4S | 50 MG
(4S)-PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader. It decreases the expression of pERK and RAS-GTP levels in a dose-dependent manner. It also significantly inhibits tumor growth in vivo.
- Shows potent SOS1 degradation activity with 56.2% and 92.5% SOS1 protein degradation at 0.1 and 1 μM, respectively, in NCI-H358 cells.
- Degrades SOS1 in a dose- and time-dependent manner in NCI-H358 cells (24 h incubation).
- Does not induce SOS2 and KRAS degradation in NCI-H358 cells (9.8-2500 nM; 24 h).
- Decreases the expression of pERK and RAS-GTP levels in NCI-H358 cells in a dose-dependent manner (7.8-2000 nM; 24 h).
- Significantly inhibits tumor growth in vivo.
Medchemexpress LLC (4S)-GLP-1 receptor agonist 14 | 2758659-09-3 | 99.6% | 880.94 | C48H46F2N10O5 | 10 MG
(4S)-GLP-1 receptor agonist 14 is a research-grade small-molecule modulator of the glucagon-like peptide-1 (GLP-1) receptor supplied as a solid for in vitro and preclinical research use. Not for human or therapeutic use.
- High purity (99.6%).
- Molecular formula C48H46F2N10O5.
- Molecular weight 880.94 g/mol.
- Appearance solid.
- Solubility in DMSO 125 mg/mL (141.89 mM); ultrasonic recommended.
- Storage: powder -20°C (up to 3 years) or 4°C (up to 2 years); in solution -80°C (up to 6 months) or -20°C (up to 1 month).
- Intended for research use only; not for human or veterinary use.
eMolecules 229184-97-8 | (4S,4'S,5R,5'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4,5-diphenyloxazole] | ChemScene484.599 | C33H28N2O2 | 97.000 | C1CC1(C1=N[C@H]([C@H](O1)c1ccccc1)c1ccccc1)C1=N[C@H]([C@H](O1)c1ccccc1)c1ccccc1 | 250mg | 811575593
(4S,4'S,5R,5'R)-2,2'-Cyclopropylidenebis[4,5-dihydro-4,5-diphenyloxazole] | ChemScene | 229184-97-8484.599 | C33H28N2O2 | 97.000 | C1CC1(C1=N[C@H]([C@H](O1)c1ccccc1)c1ccccc1)C1=N[C@H]([C@H](O1)c1ccccc1)c1ccccc1 | 250mg | 811575593
Medchemexpress LLC (2S,4S)-pyrrolidine-2-carboxamide derivative (diTFA) | 00-00-0 | 98.1% | 1279.84 g·mol⁻¹ | C61H78ClF7N10O8S | 5 MG
(4S)-PROTAC SOS1 degrader-1 (diTFA) is a research-grade PROTAC designed to induce targeted degradation of the SOS1 protein in cellular studies. It reduces SOS1 levels and downstream signaling pathways such as pERK and RAS-GTP, and is supplied as a TFA salt for preclinical research applications.
- Potent SOS1 degrader in cell-based assays.
- Reduces pERK and RAS-GTP signaling.
- High purity (~98.1%).
- Molecular weight 1279.84 g·mol⁻¹.
- Supplied as a 5 mg vial for research use.
- Certificate of analysis and safety data sheet available.
- Store at -20 °C, sealed, to preserve stability.
![Medchemexpress LLC 5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one | 1800477-35-3 | 96.9% | 327.38 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402937-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one | 1800477-35-3 | 96.9% | 327.38 | 250 MG
This chemical is 5-Amino-1,3-dimethyl-6-(3-propoxyphenoxy)-1H-benzo[d]imidazol-2(3H)-one, identified for use as a laboratory chemical and in the manufacture of substances.
- Used as a laboratory chemical.
- Used in the manufacture of substances.
- Off-white to light yellow solid.
- Recommended storage conditions for powder and in solvent.
- For research use only.