Oxazoles
Medchemexpress LLC 4-(Chloromethyl)-7-hydroxycoumarin | 25392-41-0 | 98.01% | C10H7ClO3 | 1 ML
4-(Chloromethyl)-7-hydroxycoumarin is a hydroxycoumarin derivative exhibiting potent antioxidant effects and high hydroxyl radical-scavenging properties. It contains a methyl group and a chlorine group within its heterocyclic ring and has been investigated as a potent inhibitor of zinc enzyme carbonic anhydrase isoforms CA IX and XII.
- Potent antioxidant effect
- High hydroxyl radical-scavenging property
- Investigated as inhibitors of tumor-associated carbonic anhydrase isoforms CA IX and XII
Apexbio Technology LLC Y-320 288250-47-5 10mM (in 1mL DMSO)
Y-320 (CAS 288250-47-5) is a phenylpyrazoleanilide small molecule immunomodulator that inhibits interleukin-17 (IL-17) production in CD4 T cells stimulated by IL-15 exhibiting an IC50 of 20 60 nM In vivo oral administration of Y-320 (0 3 3 mg/kg) reduces IL-17 mRNA expression and suppresses the progression of collagen-induced arthritis (CIA) in mice with additional efficacy observed in cynomolgus monkey CIA models Combination with anti-TNF- monoclonal antibody yields a synergistic effect Y-320 serves as a valuable tool for studying IL-17-mediated inflammatory pathways and for preclinical research in rheumatoid arthritis and related autoimmune diseases
![Medchemexpress LLC 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide | 199433-58-4 | >98.0% | 280.33 g/mol | C16H16N4O | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000214189.png-250.jpg)
Medchemexpress LLC 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide | 199433-58-4 | >98.0% | 280.33 g/mol | C16H16N4O | 5 MG
This small-molecule Rho-associated kinase (ROCK) inhibitor is derived from Y-27632 and demonstrates potent ROCK inhibition (IC50 3.6 nM). It also shows inhibitory activity against PKC (IC50 ≈420 nM) and CaMKII (IC50 ≈810 nM). Supplied as a solid for research use, it is intended for in vitro studies of cytoskeletal dynamics, cell morphology, and signaling pathways.
- Potent ROCK inhibition (IC50 3.6 nM).
- Activity against PKC and CaMKII at higher concentrations.
- Solid form supplied for laboratory research use.
- Suitable for studies of cytoskeletal regulation and cell motility.
- Available in small pre-weighed pack sizes for experimental flexibility.
Medchemexpress LLC Pomalidomide-C6-O-C5-O-C4-COOH | 2375774-54-0 | 98.55% | 559.65 | 25 MG
Pomalidomide-C6-O-C5-O-C4-COOH is an E3 ligase ligand-linker conjugate comprising a Pomalidomide-based cereblon ligand and linker. It can be used for the synthesis of PROTACs.
- E3 ligase ligand-linker conjugate
- Comprises a Pomalidomide-based cereblon ligand and linker
- Suitable for the synthesis of PROTACs