Pyrazoles

Medchemexpress LLC DIM-C-pPhOCH3 | 33985-68-1 | 99.4% | 352.43 | 1 ML

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DIM-C-pPhOCH3 is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor. This product is for research use only.

• Decreases survival and induces apoptosis in RKO colon cancer cells, accompanied by induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein.
• Induces Nur77-independent apoptosis.
• Inhibits cell growth after treatment for 24, 48, or 72 h, with maximum inhibitory response observed after 72 h, leading to considerable cell detachment and dead cells.
• Growth-inhibitory effects after 72 h are accompanied by markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8.
• Inhibits tumor growth in athymic nude mice bearing RKO cell xenografts.
• Significantly decreases tumor volumes and final tumor weights compared with corn oil controls in athymic nude mice bearing RKO cell xenografts.

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Medchemexpress LLC ASAH1 Human His-SU 10ug

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Recombinant human ASAH1 (acid ceramidase) is supplied as an N-terminal SUMO-6xHis fusion expressed in E. coli and provided as a lyophilized powder. The product is sequence-verified and characterized for purity and stability, and is intended for biochemical assays, enzyme characterization, and antibody validation.

• Recombinant human acid ceramidase expressed in E. coli.
• N-terminal SUMO and 6xHis fusion tag for purification and detection.
• Sequence corresponds to human ASAH1 residues Q22-W395.
• Approximate molecular weight of 58.7 kDa.
• Purity greater than 90% as determined by reducing SDS-PAGE.
• Lyophilized formulation in Tris-EDTA with trehalose for enhanced stability.
• Recommend reconstitution to ≥100 μg/mL in ddH2O and aliquot storage at -20°C or -80°C.

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eMolecules​ 2416991-31-4 | 1-Amino-spiro[1-amino-indane-2,4'-piperidine] dihydrochloride | J & W PharmLab LLC275.220 | C13H20Cl2N2 | 96.000 | Cl.Cl.NC1c2ccccc2CC11CCNCC1 | 1g | 521616652

1-Amino-spiro[1-amino-indane-2,4'-piperidine] dihydrochloride | J & W PharmLab LLC | 2416991-31-4275.220 | C13H20Cl2N2 | 96.000 | Cl.Cl.NC1c2ccccc2CC11CCNCC1 | 1g | 521616652

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eMolecules​ 2075-45-8 | 4-Bromo-1H-pyrazole | Combi-Blocks | MFCD00075602 | 146.975 | C3H3BrN2 | 95.000 | Brc1cn[nH]c1 | 100g | 117534658

4-Bromo-1H-pyrazole | Combi-Blocks | 2075-45-8 | MFCD00075602 | 146.975 | C3H3BrN2 | 95.000 | Brc1cn[nH]c1 | 100g | 117534658

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eMolecules​ 2075-45-8 | 4-Bromo-1H-pyrazole | Combi-Blocks | MFCD00075602 | 146.975 | C3H3BrN2 | 95.000 | Brc1cn[nH]c1 | 5g | 117534656

4-Bromo-1H-pyrazole | Combi-Blocks | 2075-45-8 | MFCD00075602 | 146.975 | C3H3BrN2 | 95.000 | Brc1cn[nH]c1 | 5g | 117534656

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eMolecules​ 871587-68-7 | 3-(3-Fluoro-phenoxy)-pyrrolidine | J & W PharmLab LLC | MFCD08687904 | 181.210 | C10H12FNO | 96.000 | Fc1cccc(OC2CCNC2)c1 | 5g | 289356162

3-(3-Fluoro-phenoxy)-pyrrolidine | J & W PharmLab LLC | 871587-68-7 | MFCD08687904 | 181.210 | C10H12FNO | 96.000 | Fc1cccc(OC2CCNC2)c1 | 5g | 289356162

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eMolecules​ 885278-45-5 | Ethyl 5-amino-1H-indazole-3-carboxylate | J & W PharmLab, LLC | MFCD07371582 | 205.217 | C10H11N3O2 | 96.000 | CCOC(=O)c1n[nH]c2ccc(N)cc12 | 5g | 250006307

Ethyl 5-amino-1H-indazole-3-carboxylate | J & W PharmLab, LLC | 885278-45-5 | MFCD07371582 | 205.217 | C10H11N3O2 | 96.000 | CCOC(=O)c1n[nH]c2ccc(N)cc12 | 5g | 250006307

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eMolecules​ 1107604-11-4 | C-(1-Benzyl-1H-pyrazol-4-yl)-methylamine hydrochloride | J & W PharmLab, LLC | MFCD06739004 | 223.700 | C11H14ClN3 | 96.000 | Cl.NCc1cnn(Cc2ccccc2)c1 | 5g | 250014954

C-(1-Benzyl-1H-pyrazol-4-yl)-methylamine hydrochloride | J & W PharmLab, LLC | 1107604-11-4 | MFCD06739004 | 223.700 | C11H14ClN3 | 96.000 | Cl.NCc1cnn(Cc2ccccc2)c1 | 5g | 250014954

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eMolecules​ 20157-44-2 | 1-o-Tolyl-1H-pyrazole | Combi-Blocks | MFCD12192640 | 158.204 | C10H10N2 | 98.000 | Cc1ccccc1-n1cccn1 | 25g | 357558161

1-o-Tolyl-1H-pyrazole | Combi-Blocks | 20157-44-2 | MFCD12192640 | 158.204 | C10H10N2 | 98.000 | Cc1ccccc1-n1cccn1 | 25g | 357558161

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eMolecules​ 67460-86-0 | 3,5-Dibromo-1H-pyrazole | ChemScene | MFCD00159645 | 225.871 | C3H2Br2N2 | 97.000 | Brc1cc(Br)[nH]n1 | 1g | 569144446

3,5-Dibromo-1H-pyrazole | ChemScene | 67460-86-0 | MFCD00159645 | 225.871 | C3H2Br2N2 | 97.000 | Brc1cc(Br)[nH]n1 | 1g | 569144446

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eMolecules​ 79080-39-0 | 1-methyl-1H-pyrazole-3-carbonitrile | Pharmablock | MFCD00466343 | 107.116 | C5H5N3 | 97.000 | Cn1ccc(n1)C#N | 10g | 551070919

1-methyl-1H-pyrazole-3-carbonitrile | Pharmablock | 79080-39-0 | MFCD00466343 | 107.116 | C5H5N3 | 97.000 | Cn1ccc(n1)C#N | 10g | 551070919

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eMolecules​ 67460-86-0 | 3,5-Dibromo-1H-pyrazole | Combi-Blocks, Inc. | MFCD00159645 | 225.871 | C3H2Br2N2 | 97.000 | Brc1cc(Br)[nH]n1 | 25g | 586071464

3,5-Dibromo-1H-pyrazole | Combi-Blocks, Inc. | 67460-86-0 | MFCD00159645 | 225.871 | C3H2Br2N2 | 97.000 | Brc1cc(Br)[nH]n1 | 25g | 586071464

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eMolecules​ 763120-58-7 | 1H-PYRAZOLE-4-BORONIC ACID | AstaTech | MFCD07368251 | 111.900 | C3H5BN2O2 | 95.000 | OB(O)c1cn[nH]c1 | 25g | 281902594

1H-PYRAZOLE-4-BORONIC ACID | AstaTech | 763120-58-7 | MFCD07368251 | 111.900 | C3H5BN2O2 | 95.000 | OB(O)c1cn[nH]c1 | 25g | 281902594

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eMolecules​ 288148-34-5 | 1-Methyl-1H-pyrazole-4-sulfonyl chloride | ChemScene | MFCD04968667 | 180.610 | C4H5ClN2O2S | 95.000 | Cn1cc(cn1)S(Cl)(=O)=O | 5g | 536850982

1-Methyl-1H-pyrazole-4-sulfonyl chloride | ChemScene | 288148-34-5 | MFCD04968667 | 180.610 | C4H5ClN2O2S | 95.000 | Cn1cc(cn1)S(Cl)(=O)=O | 5g | 536850982

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eMolecules​ 13808-64-5 | 4-bromo-3-methyl-1H-pyrazole | Pharmablock | MFCD00005241 | 161.002 | C4H5BrN2 | 97.000 | Cc1n[nH]cc1Br | 2.5g | 686936375

4-bromo-3-methyl-1H-pyrazole | Pharmablock | 13808-64-5 | MFCD00005241 | 161.002 | C4H5BrN2 | 97.000 | Cc1n[nH]cc1Br | 2.5g | 686936375

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