Thiazoles

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1,756 – 1,770 of 1,981 results

1,756

Medchemexpress LLC Met kinase-IN-2 | 2101241-90-9 | 98.4% | C33H27FN4O4 | 10MG

MET kinase-IN-2 is a potent, selective, orally bioavailable inhibitor of the MET (c-Met/HGFR) receptor tyrosine kinase. It inhibits MET with an IC50 of 7.4 nM, shows antitumor activity in cell-based assays, and has reported activity against several additional kinases and tumor cell lines. Supplied as a solid research chemical for laboratory use.

Potent MET kinase inhibition (IC50 = 7.4 nM).
Orally bioavailable, enabling in vivo studies.
Demonstrated antitumor activity in cell assays.
Shows additional kinase activity at higher concentrations.
High-purity solid suitable for research applications.

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1,757

Apexbio Technology LLC Cytochrome c fragment (93-108) 25mg

Cytochrome c fragment 93-108 is a peptide derived from cytochrome c a mitochondrial protein involved in apoptosis It is designed to interact with apoptotic protease activating factor-1 (Apaf-1) thereby promoting the assembly of the Apaf-1/caspase-9 apoptosome complex and regulating the caspase activation pathway Cytochrome c fragment 93-108 exerts its biological activity primarily through activation of the caspase cascade specifically the activation of caspase-9 and subsequent caspase-3 Based on these pharmacological properties cytochrome c fragment 93-108 holds research potential in studies of apoptosis-related signaling networks caspase activation pathways and drug screening targeting apoptosis regulators

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1,758

Medchemexpress LLC Yl-5092 | 3056857-07-6 | 99.8% | 441.43 | C22H14F3N3O2S | 10 MG

YL-5092 is a selective inhibitor of YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) with potent biochemical activity and demonstrated efficacy in acute myeloid leukemia models. It is used in research probing m6A-mediated RNA regulation and cancer biology, and is supplied as a characterized, high-purity solid for in vitro and in vivo studies.

Selective inhibition of YTHDC1 (IC50 7.4 nM; KD 29.6 nM).
Demonstrated cellular activity against AML cell lines and efficacy in xenograft models.
Induces G0/G1 phase arrest and apoptosis in cancer cells.
High reported purity and defined physicochemical properties for reproducible results.
Soluble in DMSO (100 mg/mL) and formulatable for in vivo use (≥2.5 mg/mL in standard vehicle).

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1,759

Medchemexpress LLC 1,3-oxazolidine-2-thione | 5840-81-3 | MFCD00125763 | ≥98.0% | 103.15 g/mol | C3H5NOS | 10 MG

1,3-oxazolidine-2-thione (CAS 5840-81-3) is a small heterocyclic organosulfur compound supplied for laboratory research and reference use. It is typically a white to off-white solid with molecular formula C3H5NOS and molecular weight about 103.15 g/mol. The substance has been used in biological studies and is provided with specified purity for experimental applications.

Small heterocyclic organosulfur compound
White to off-white solid appearance
Molecular formula C3H5NOS and molecular weight 103.15 g/mol
Soluble in DMSO (common laboratory solvent)
Supplied with reported purity ≥98.0%
Intended for laboratory research and reference use only

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1,760

eMolecules Ambeed 2 5-Dioxopyrrolidin-1-yl 2 5 8 11 14 17 20 23 26 29 32 35 38 41 44 47-hexadecaoxapentacontan-50-oate 50mg 811906054 A1662119 0 000 2563873-83-4 MFCD13184971 861 973 C38H71NO20

Ambeed 2 5-Dioxopyrrolidin-1-yl 2 5 8 11 14 17 20 23 26 29 32 35 38 41 44 47-hexadecaoxapentacontan-50-oate 50mg 811906054 A1662119 0 000 2563873-83-4 MFCD13184971 861 973 C38H71NO20

Pricing & Availability

1,761

Apexbio Technology LLC TH-302 918633-87-1 200mg

TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity

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1,762

Apexbio Technology LLC KN-93 139298-40-1 25mg

KN-93 (CAS 139298-40-1) is a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII) a serine/threonine kinase activated by calcium-bound calmodulin KN-93 inhibits CaMKII enzymatic activity with reported IC50 values of approximately 0 37 0 5 M in vitro and a Ki value of 2 58 M against cardiac CaMKII In NIH 3T3 cells KN-93 (12 M) induces G1 cell-cycle arrest and at higher concentrations (24 M) promotes apoptosis Due to CaMKII s role in neuronal function cardiac signaling immune activation and disease states including Alzheimer s and arrhythmias KN-93 serves as a tool compound for studying CaMKII-mediated processes in biomedical research

Pricing & Availability

1,763

Medchemexpress LLC M-isobutyl ibuprofen | 66622-47-7 | MFCD08275582 | >=98.0% | 206.28 g/mol | C13H18O2 | 5 MG

m-Isobutyl Ibuprofen (Compound IMP-A) is an impurity produced during the synthesis of ibuprofen and is supplied as a research-grade impurity standard for analytical and quality-control applications. The material is intended for laboratory and research use only and should be handled according to the certificate of analysis and institutional safety procedures.

Reference impurity for analytical and quality-control use.
Intended for research use only, not for human or veterinary use.
Available in small milligram pack sizes suitable for method development.
Molecular formula C13H18O2; molecular weight 206.28 g/mol.
Storage conditions provided in the certificate of analysis; follow laboratory safety guidance.

Pricing & Availability

1,764

eMolecules ChemScene / 1-(3-Bromoisoxazol-5-yl)ethanone / 100mg / 795362638 / CS-0436819 / 0.000 / 76596-53-7 / MFCD18801045 / 189.996 / C5H4BrNO2

ChemScene / 1-(3-Bromoisoxazol-5-yl)ethanone / 100mg / 795362638 / CS-0436819 / 0.000 / 76596-53-7 / MFCD18801045 / 189.996 / C5H4BrNO2

Pricing & Availability

1,765

BIOHIPPO AAV-TH-fDIO-hChR2(H134R)-mCherry-WPRE-hGH-polyA

Recombinant adeno associated virus expressing hChR2(H134R) fused to mCherry under the TH promoter with WPRE and hGH polyA elements. The Cre and Flp logic configuration enables expression only after recombination, providing precise optogenetic control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.

Pricing & Availability

1,766

BIOHIPPO AAV-TH-DIO-Chronos-EGFP-WPRE-hGH-polyA

Recombinant adeno associated virus expressing Chronos fused to EGFP under the TH promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise optogenetic control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.

Pricing & Availability

1,767

eMolecules Key Organics/BIONET 2 5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)ethyl) carbonate 1mg 564099965 AS-10140 98 000 78269-85-9 MFCD02683467 259 333 C10H17NO5Si

Key Organics/BIONET 2 5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)ethyl) carbonate 1mg 564099965 AS-10140 98 000 78269-85-9 MFCD02683467 259 333 C10H17NO5Si

Pricing & Availability

1,768

Medchemexpress LLC 4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | 2097381-85-4 | MFCD30742947 | >=98.0% | 523.6 g/mol | C27H33N5O4S | 25 MG

VH-298 is a cell-active small-molecule inhibitor of the VHL:HIF-α interaction used as a research tool to stabilize HIF-α and investigate hypoxia signaling and targeted protein degradation. It is applicable to biochemical and cellular assays and is commonly used in PROTAC development.

Potent inhibitor of VHL:HIF-α interaction.
Cell-active; promotes HIF-α accumulation in cells.
Useful as a tool compound in hypoxia signaling studies and PROTAC research.
High purity suitable for biochemical and cellular assays.
Well-characterized chemical identifiers for compound tracking.

Pricing & Availability

1,769

Medchemexpress LLC MM-02-57 | 404.89 | 5 MG

MM-02-57 is a covalent DDB1 CUL4A adaptor protein recruiter. It is intended for research use only and not for sale to patients. This product is supplied as a solid, appearing white to off-white.

Covalent DDB1 CUL4A adaptor protein recruiter
Suitable for research use only
Supplied as a white to off-white solid

Pricing & Availability

1,770

eMolecules Diethyl (6-methyl-2-pyridylaminomethylene)malonate | 13250-95-8 | MFCD00023437 | 1g

Oakwood Chemical | Diethyl (6-methyl-2-pyridylaminomethylene)malonate | 1g | 537707396 | 099216 | | 13250-95-8 | MFCD00023437 | 278.308 | C14H18N2O4

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Thiazoles

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Medchemexpress LLC Met kinase-IN-2 | 2101241-90-9 | 98.4% | C33H27FN4O4 | 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Cytochrome c fragment (93-108) 25mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Yl-5092 | 3056857-07-6 | 99.8% | 441.43 | C22H14F3N3O2S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1,3-oxazolidine-2-thione | 5840-81-3 | MFCD00125763 | ≥98.0% | 103.15 g/mol | C3H5NOS | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC TH-302 918633-87-1 200mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC KN-93 139298-40-1 25mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC M-isobutyl ibuprofen | 66622-47-7 | MFCD08275582 | >=98.0% | 206.28 g/mol | C13H18O2 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

BIOHIPPO AAV-TH-fDIO-hChR2(H134R)-mCherry-WPRE-hGH-polyA Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

BIOHIPPO AAV-TH-DIO-Chronos-EGFP-WPRE-hGH-polyA Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | 2097381-85-4 | MFCD30742947 | >=98.0% | 523.6 g/mol | C27H33N5O4S | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MM-02-57 | 404.89 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More