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Filtered Search Results
Apexbio Technology LLC TH-302 918633-87-1 10mg
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
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Aobchem (5-Ethylthiophen-2-yl)methanol | 95% | CAS 159058-69-2 | C7H10OS | 250mg
(5-Ethylthiophen-2-yl)methanol | 95% | CAS 159058-69-2 | C7H10OS | 250mg
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Aobchem 2-Chloro-3-methoxy-4-(methylthio)-1-(trifluoromethyl)benzene | 95% | CAS 2706344-27-4 | C9H8ClF3OS | 250mg
2-Chloro-3-methoxy-4-(methylthio)-1-(trifluoromethyl)benzene | 95% | CAS 2706344-27-4 | C9H8ClF3OS | 250mg
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Aobchem 1-(2 3-Difluoropyridin-4-yl)-2 2 2-trifluoroethanone | 97% | CAS 2353676-11-4 | C7H2F5NO | 5g
1-(2 3-Difluoropyridin-4-yl)-2 2 2-trifluoroethanone | 97% | CAS 2353676-11-4 | C7H2F5NO | 5g
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Aobchem AOBCHEM
5000943447 3-FORMYL-5-METHYL-2- METHYLTH
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Aobchem 2-Phenylthiazole | ≥97% | CAS 1826-11-5 | C9H7NS | 10g
2-Phenylthiazole | ≥97% | CAS 1826-11-5 | C9H7NS | 10g
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Ambeed AMBEED
5000948734 1-4-2-HYDROXYPROPAN-2-YL 100MG
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Ambeed AMBEED
5000949370 2-BENZODTHIAZOL-2-YL-46- 100MG
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Ambeed AMBEED
5000949608 IITZ-02 10MG
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Aobchem AOBCHEM
5001007689 4- 2 6-DIFLUOROPYRIDIN-3-YL -1
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Aobchem AOBCHEM
5001007720 1- 2 6-DIFLUOROPYRIDIN-3-YL CY
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Aobchem AOBCHEM
5001008184 1- 2 6-DIFLUOROPYRIDIN-3-YL CY
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Aobchem 5-(Sec-butyl)-2-fluorobenzaldehyde | 97% | C11H13FO | 1g
5-(Sec-butyl)-2-fluorobenzaldehyde | 97% | C11H13FO | 1g
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Aobchem -(1-Methylpropyl)-3-(methylthio)benzenemethanol | 97% | CAS 2283964-09-8 | C12H18OS | 500mg
-(1-Methylpropyl)-3-(methylthio)benzenemethanol | 97% | CAS 2283964-09-8 | C12H18OS | 500mg
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Aobchem 6-Methoxy-2-methyl-3-(methylthio)pyridine | 95% | CAS 2921840-85-7 | C8H11NOS | 250mg
6-Methoxy-2-methyl-3-(methylthio)pyridine | 95% | CAS 2921840-85-7 | C8H11NOS | 250mg
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