Thiazoles

Medchemexpress LLC TH-Z93 | 2260887-09-8 | C12H22N2O7P2 | 25 MG

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TH-Z93 is a lipophilic bisphosphonate and an FPPS inhibitor with an IC50 of 90 nM. It has shown strong prophylactic effects in a pathogenic influenza model and inhibited tumor growth in a B16-OVA cells xenograft mice model, making it suitable for various research applications.

• Lipophilic bisphosphonate
• FPPS inhibitor (IC50: 90 nM)
• Shows strong prophylactic effects in pathogenic influenza model
• Inhibits tumor growth in B16-OVA cells xenograft mice model
• High purity (98.41%)
• Available in various package sizes

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Medchemexpress LLC JH-XI-10-02 | 2209085-22-1 | 99.7% | 920.14 | 25 MG

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JH-XI-10-02 is a PROTAC that connects ligands for Cereblon and CDK. It is a highly potent and selective PROTAC CDK8 degrader with an IC50 of 159 nM. This compound causes proteasomal degradation and does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19.

• Highly potent and selective PROTAC CDK8 degrader.
• Causes proteasomal degradation.
• Does not affect CDK8 mRNA levels.
• Shows no effect on CDK19.
• Induces partial degradation of CDK8 in Jurkat cells after 6 hours and significant degradation after 24 hours at 1 μM.
• Induces degradation of CDK8 at 5 μM in WT Molt4 cells, but not in CRBN null Molt4 cells.

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BIOHIPPO scAAV-TH-NLS-Cre-WPREs

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Recombinant adeno associated virus expressing Cre under the TH promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.

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Medchemexpress LLC phospho-ERK1 + 2 (Thr183/Tyr185) Antibody | 50 UL

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phospho-ERK1 + 2 (Thr183/Tyr185) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting phospho-ERK1 + 2 (Thr183/Tyr185). It is supplied in 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. This antibody targets the MAP kinase family, involved in cellular processes like proliferation, differentiation, and cell cycle progression. It is activated by upstream kinases, phosphorylating nuclear targets.

• Host: Rabbit
• Clonality: Polyclonal
• Species reactivity: Human, Mouse
• Purity: Affinity purified
• Conjugation: Non-conjugated
• Modification: Phosphorylated
• Isotype: IgG
• Appearance: Liquid
• Applications: WB, ELISA, IHC-P, IHC-F, ICC/IF

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eMolecules​ 72914-19-3 | DTBBPY | Ambeed | MFCD01863731 | 268.404 | C18H24N2 | 98.000 | CC(C)(C)c1ccnc(c1)-c1cc(ccn1)C(C)(C)C | 5g | 524992408

DTBBPY | Ambeed | 72914-19-3 | MFCD01863731 | 268.404 | C18H24N2 | 98.000 | CC(C)(C)c1ccnc(c1)-c1cc(ccn1)C(C)(C)C | 5g | 524992408

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eMolecules​ 88796-28-5 | AstaTech | ETHYL 5-AMINO-3-METHYLTHIOPHENE-2-CARBOXYLATE | 0.25g | 718066345 | E78251 | 95 | MFCD02257685 | 185.24 | C8H11NO2S

AstaTech | ETHYL 5-AMINO-3-METHYLTHIOPHENE-2-CARBOXYLATE | 0.25g | 718066345 | E78251 | 95.000 | 88796-28-5 | MFCD02257685 | 185.240 | C8H11NO2S

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Medchemexpress LLC 2 4-Dimethylthiazole | 1G

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2 4-Dimethylthiazole | 1G

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Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone | 141627-42-1 | 99.6% | C20H19NO5 | 25 G

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(2-Butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone is a drug intermediate for the synthesis of various active compounds. It is for research use only.

• Used as a drug intermediate for active compound synthesis
• Molecular weight: 353.37
• Chemical formula: C20H19NO5
• Appearance: Solid, yellow to brown
• Shipping: Room temperature in continental US
• Storage (powder): -20°C for 3 years, 4°C for 2 years
• Storage (in solvent): -80°C for 6 months, -20°C for 1 month

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Medchemexpress LLC BAY-298 | 2471978-97-7 | 99.9% | 10 MM * 1 ML

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BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It demonstrates potent activity against human, rat, and cynomolgus monkey LH receptors, effectively reducing sex hormone levels. It is supplied as a 10 MM solution in DMSO.

• Orally active and selective LH-R antagonist
• Reduces sex hormone levels
• Potent inhibitory activity against human, rat, and cynomolgus monkey LH receptors
• Inhibits human ERG in HEK293 cells
• Lowers serum estradiol levels in proestrus female rats

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Medchemexpress LLC Imidazo[1,2-a]pyrazine, 8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | 3023925-68-7 | C25H26N6O | 50 MG

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YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis and has shown to ameliorate liver damage in an Acetaminophen (APAP)-induced acute liver injury model.

• Potent ferroptosis inhibitor
• Targets the PHB2/ferritin/iron axis
• Protects cells from ferroptosis
• Reduces ROS levels in cytosolic and membrane lipids
• Inhibits ferritinophagy by improving ferritin protein expression
• Ameliorates liver damage in APAP-induced acute liver injury models
• High purity of 99.03%
• Solid appearance, off-white to light yellow color

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Chemscene ChemScene | (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride | 250MG | CS-0100156 | 0.98 | 1448189-90-9| MFCD31803433 | 353.88

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ChemScene | (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride | 250MG | CS-0100156 | 0.98 | 1448189-90-9| MFCD31803433 | 353.88

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BIOHIPPO AAV-TH-fDIO-eNpHR3.0-mCherry-WPRE-hGH-polyA

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Recombinant adeno associated virus expressing eNpHR3.0 fused to mCherry under the TH promoter with WPRE and hGH polyA elements. The Cre and Flp logic configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.

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eMolecules​ 95408-45-0 | 1,1'-Bis(di-tert-butylphosphino) ferrocene palladium chloride | Oakwood Chemicals | MFCD08064219 | 651.750 | C26H44Cl2FeP2Pd | 98.000 | [Cl-].[Cl-].[Fe].[Pd++].CC(C)(C)P(c1cccc1)C(C)(C)C.CC(C)(C)P(c1cccc1)C(C)(C)C | 5g | 480131030

1,1'-Bis(di-tert-butylphosphino) ferrocene palladium chloride | Oakwood Chemicals | 95408-45-0 | MFCD08064219 | 651.750 | C26H44Cl2FeP2Pd | 98.000 | [Cl-].[Cl-].[Fe].[Pd++].CC(C)(C)P(c1cccc1)C(C)(C)C.CC(C)(C)P(c1cccc1)C(C)(C)C | 5g | 480131030

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