Thiazoles
eMolecules 99469-77-9 | ChemScene | 4-Hydrazinyl-6-(methylthio)pyrimidine | 100mg | 536790960 | CS-0045658 | MFCD19201836 | 156.21 | C5H8N4S
ChemScene | 4-Hydrazinyl-6-(methylthio)pyrimidine | 100mg | 536790960 | CS-0045658 | 99469-77-9 | MFCD19201836 | 156.210 | C5H8N4S
Apexbio Technology LLC TH-302 918633-87-1 200mg
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
eMolecules 585-48-8 | 2,6-Di-tert-butylpyridine | Chem-Impex | MFCD00006306 | 191.318 | C13H21N | 99.000 | CC(C)(C)c1cccc(n1)C(C)(C)C | 25g | 489819715
2,6-Di-tert-butylpyridine | Chem-Impex | 585-48-8 | MFCD00006306 | 191.318 | C13H21N | 99.000 | CC(C)(C)c1cccc(n1)C(C)(C)C | 25g | 489819715
eMolecules 75824-03-2 | Ethyl 5-Chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate | Accela ChemBio | MFCD09953614 | 233.670 | C7H8ClN3O2S | 95.000 | CCOC(=O)c1nnc(SC)nc1Cl | 10g | 772325344
Ethyl 5-Chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate | Accela ChemBio | 75824-03-2 | MFCD09953614 | 233.670 | C7H8ClN3O2S | 95.000 | CCOC(=O)c1nnc(SC)nc1Cl | 10g | 772325344
(C)OCCBr | 1g | 459636791](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000165670.jpg-250.jpg)
eMolecules 86864-60-0 | (2-Bromoethoxy)(tert-butyl)dimethylsilane | Synthonix - Stock | MFCD00209550 | 239.228 | C8H19BrOSi | 96.000 | CC(C)(C)[Si](C)(C)OCCBr | 1g | 459636791
(2-Bromoethoxy)(tert-butyl)dimethylsilane | Synthonix - Stock | 86864-60-0 | MFCD00209550 | 239.228 | C8H19BrOSi | 96.000 | CC(C)(C)[Si](C)(C)OCCBr | 1g | 459636791
(C)OCCBr | 25g | 459636794](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000165933.jpg-250.jpg)
eMolecules 86864-60-0 | (2-Bromoethoxy)(tert-butyl)dimethylsilane | Synthonix - Stock | MFCD00209550 | 239.228 | C8H19BrOSi | 96.000 | CC(C)(C)[Si](C)(C)OCCBr | 25g | 459636794
(2-Bromoethoxy)(tert-butyl)dimethylsilane | Synthonix - Stock | 86864-60-0 | MFCD00209550 | 239.228 | C8H19BrOSi | 96.000 | CC(C)(C)[Si](C)(C)OCCBr | 25g | 459636794
eMolecules 96989-50-3 | O,O-Di(pyridin-2-yl) carbonothioate | Oakwood Chemicals | MFCD00074870 | 232.260 | C11H8N2O2S | 90.000 | S=C(Oc1ccccn1)Oc1ccccn1 | 1g | 486567748
O,O-Di(pyridin-2-yl) carbonothioate | Oakwood Chemicals | 96989-50-3 | MFCD00074870 | 232.260 | C11H8N2O2S | 90.000 | S=C(Oc1ccccn1)Oc1ccccn1 | 1g | 486567748
![eMolecules 548762-66-9 | tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix - Stock214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 5g | 505078115](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471921.jpg-250.jpg)
eMolecules 548762-66-9 | tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix - Stock214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 5g | 505078115
tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix - Stock | 548762-66-9214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 5g | 505078115
![eMolecules 548762-66-9 | tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 25g | 761955091](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471225.jpg-250.jpg)
eMolecules 548762-66-9 | tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 25g | 761955091
tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix | 548762-66-9214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 25g | 761955091
eMolecules 38862-24-7 | 2,5-Dioxopyrrolidin-1-yl acrylate | Ambeed | MFCD00078261 | 169.136 | C7H7NO4 | 97.000 | C=CC(=O)ON1C(=O)CCC1=O | 100g | 718039454
2,5-Dioxopyrrolidin-1-yl acrylate | Ambeed | 38862-24-7 | MFCD00078261 | 169.136 | C7H7NO4 | 97.000 | C=CC(=O)ON1C(=O)CCC1=O | 100g | 718039454
![Aobchem 2-(Benzo[d]thiazol-2-yl)-5-methylphenol | ≥97% | CAS 56048-54-5 | C14H11NOS | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000994211.png-250.jpg)
Aobchem 2-(Benzo[d]thiazol-2-yl)-5-methylphenol | ≥97% | CAS 56048-54-5 | C14H11NOS | 1g
2-(Benzo[d]thiazol-2-yl)-5-methylphenol | ≥97% | CAS 56048-54-5 | C14H11NOS | 1g