Thiazoles
Aobchem (2-Fluoro-5-formyl-3-(methylthio)phenyl)boronic acid | 95% | C8H8BFO3S | 1g
(2-Fluoro-5-formyl-3-(methylthio)phenyl)boronic acid | 95% | C8H8BFO3S | 1g
![Medchemexpress LLC (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy | 2097381-85-4 | MFCD30742947 | >98.0% | 523.65 g/mol | C27H33N5O4S | 2 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211825.png-250.jpg)
Medchemexpress LLC (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy | 2097381-85-4 | MFCD30742947 | >98.0% | 523.65 g/mol | C27H33N5O4S | 2 MG
VH-298 is a potent, cell-permeable small molecule that inhibits the VHL:HIF-α protein-protein interaction, stabilizing HIF-α and inducing a hypoxic response in cells. It is commonly used as a chemical probe and as an E3 ligase ligand in the design of PROTACs for cell-based studies.
- High binding affinity (Kd ≈ 80-90 nM).
- Cell-permeable and reported non-toxic in cellular assays.
- Induces HIF-α accumulation in treated cells.
- Useful as an E3 ligase ligand for PROTAC construction.
- Supplied as a small-molecule solid suitable for synthesis and biological assays.
Aobchem 2-(5-Iodothiophen-2-yl)-4 4 5 5-tetramethyl-1 3 2-dioxaborolane | 97% | CAS 942070-24-8 | C10H14BIO2S | 1g
2-(5-Iodothiophen-2-yl)-4 4 5 5-tetramethyl-1 3 2-dioxaborolane | 97% | CAS 942070-24-8 | C10H14BIO2S | 1g
Aobchem 1-(2-Ethoxythiazol-5-yl)-2 2 2-trifluoroethanone | 95% | C7H6F3NO2S | 1g
1-(2-Ethoxythiazol-5-yl)-2 2 2-trifluoroethanone | 95% | C7H6F3NO2S | 1g
Aobchem 3-Chloro-2-methoxy-4-(methylthio)pyridine | 97% | CAS 2764728-58-5 | C7H8ClNOS | 1g
3-Chloro-2-methoxy-4-(methylthio)pyridine | 97% | CAS 2764728-58-5 | C7H8ClNOS | 1g
Aobchem 3-Chloro-2-methoxy-4-(methylthio)pyridine | 97% | CAS 2764728-58-5 | C7H8ClNOS | 5g
3-Chloro-2-methoxy-4-(methylthio)pyridine | 97% | CAS 2764728-58-5 | C7H8ClNOS | 5g
Aobchem 3-Fluoro-4-methoxy-2-(methylthio)aniline | 95% | CAS 2586127-54-8 | C8H10FNOS | 250mg
3-Fluoro-4-methoxy-2-(methylthio)aniline | 95% | CAS 2586127-54-8 | C8H10FNOS | 250mg
![Aobchem N-(6-bromobenzo[d]thiazol-2-yl)acetamide | ≥95% | CAS 16628-26-5 | C9H7BrN2OS | 5g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000987735.png-250.jpg)
Aobchem N-(6-bromobenzo[d]thiazol-2-yl)acetamide | ≥95% | CAS 16628-26-5 | C9H7BrN2OS | 5g
N-(6-bromobenzo[d]thiazol-2-yl)acetamide | ≥95% | CAS 16628-26-5 | C9H7BrN2OS | 5g
Aobchem (3 6-Dimethoxypyridazin-4-yl)methanol | 95% | CAS 89943-57-7 | C7H10N2O3 | 500mg
(3 6-Dimethoxypyridazin-4-yl)methanol | 95% | CAS 89943-57-7 | C7H10N2O3 | 500mg
Aobchem Ethanone 2-chloro-1-(2 3-dihydro-5-benzofuranyl)- | ≥95% | CAS 64089-34-5 | C10H9ClO2 | 1g
Ethanone 2-chloro-1-(2 3-dihydro-5-benzofuranyl)- | ≥95% | CAS 64089-34-5 | C10H9ClO2 | 1g
Apexbio Technology LLC TH-302 918633-87-1 10mg
TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
Medchemexpress LLC N-Methylindan-2-amine hydrochloride | 10408-85-2 | 99.9% | 183.68 | 5 G
N-Methylindan-2-amine hydrochloride (compound 3b) is an N-alkylated congener of phenylethylamine that increases hot plate reaction time in mice without inducing dopaminergic effects. It can be used to study central noradrenergic mechanisms. This product is for research use only and not sold to patients.
- Used to study central noradrenergic mechanisms
- Increases hot plate reaction time in mice
- Does not induce dopaminergic effects
Aobchem 2-Methyl-1-(4-methyl-2-thiazolyl)-1-propanone | ≥95% | CAS 1516520-01-6 | C8H11NOS | 5g
2-Methyl-1-(4-methyl-2-thiazolyl)-1-propanone | ≥95% | CAS 1516520-01-6 | C8H11NOS | 5g
Aobchem (5 6-Dimethoxypyridin-3-yl)methanol | 97% | CAS 1138443-89-6 | C8H11NO3 | 500mg
(5 6-Dimethoxypyridin-3-yl)methanol | 97% | CAS 1138443-89-6 | C8H11NO3 | 500mg
Medchemexpress LLC Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate | 179003-02-2 | 279.34 | 250 MG
Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate is a drug intermediate used for the synthesis of various active compounds. It is intended for research use only and should be handled by suitably qualified, experienced personnel in appropriately equipped facilities.
- Used as a drug intermediate.
- Suitable for synthesis of various active compounds.
- Identified for laboratory chemical use.
- Intended for manufacture of substances.
- For research use only.