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Filtered Search Results
Medchemexpress LLC BAY-298 | 2471978-97-7 | 99.9% | 10 MM * 1 ML
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BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist. It demonstrates potent activity against human, rat, and cynomolgus monkey LH receptors, effectively reducing sex hormone levels. It is supplied as a 10 MM solution in DMSO.
- Orally active and selective LH-R antagonist
- Reduces sex hormone levels
- Potent inhibitory activity against human, rat, and cynomolgus monkey LH receptors
- Inhibits human ERG in HEK293 cells
- Lowers serum estradiol levels in proestrus female rats
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Medchemexpress LLC Imidazo[1,2-a]pyrazine, 8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | 3023925-68-7 | C25H26N6O | 50 MG
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YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis and has shown to ameliorate liver damage in an Acetaminophen (APAP)-induced acute liver injury model.
- Potent ferroptosis inhibitor
- Targets the PHB2/ferritin/iron axis
- Protects cells from ferroptosis
- Reduces ROS levels in cytosolic and membrane lipids
- Inhibits ferritinophagy by improving ferritin protein expression
- Ameliorates liver damage in APAP-induced acute liver injury models
- High purity of 99.03%
- Solid appearance, off-white to light yellow color
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Medchemexpress LLC Phospho-Met c-Met antibody (YA175) | Protein A affinity purified | Predicted band size: 156 kDa; Observed band size: 170/140 kDa | 50 UL
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MET is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor (HGF) ligand. It regulates various physiological processes, including proliferation, scattering, morphogenesis, and survival. This antibody is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Phospho-Met c-Met. It is supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol with 0.05% Sodium Azide as a preservative.
- Targets Phospho-Met c-Met
- Rabbit-derived monoclonal antibody
- Reacts with human samples
- Purified using protein A affinity
- Applicable in Western blot (WB) and immunohistochemistry-paraffin (IHC-P)
- For research use only
- Avoid repeated freeze / thaw cycles
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Medchemexpress LLC TA-02 | 1784751-19-4 | 99.9% | 333.33 g/mol | C20H13F2N3 | 10 MG
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This small-molecule research compound is a potent p38 MAPK inhibitor reported to have an IC50 of 20 nM and additional activity against TGFBR-2. It is supplied as a high-purity solid or DMSO solution for biochemical and cellular studies.
- Potent p38 MAPK inhibition (IC50 = 20 nM).
- Also inhibits TGFBR-2.
- High purity (99.9%).
- Available as small solid quantities (e.g., 10 mg) and as a DMSO solution.
- Suitable for biochemical and cellular assay applications.
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eMolecules 58304-65-7 | AstaTech | 1-CHLORO-2-METHYLPROPYL PROPIONATE | 1g | 233619311 | 25803 | 95 | MFCD09033184 | 164.63 | C7H13ClO2
AstaTech | 1-CHLORO-2-METHYLPROPYL PROPIONATE | 1g | 233619311 | 25803 | 95.000 | 58304-65-7 | MFCD09033184 | 164.630 | C7H13ClO2
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Medchemexpress LLC Met kinase-IN-2 | 2101241-90-9 | 98.4% | 562.59 g/mol | C33H27FN4O4 | 5 MG
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MET kinase-IN-2 is a potent, selective MET (c-Met/HGFR) kinase inhibitor with an enzymatic IC50 of 7.4 nM. The compound shows cellular growth inhibition across multiple cancer cell lines and demonstrates oral antitumor efficacy in xenograft models. It is supplied for preclinical research and is well characterized for purity and molecular properties.
- Potent MET kinase inhibition (IC50 7.4 nM).
- Selective profile with additional activity against AXL, Flt4, KDR, Mer, TEK, and TYRO3.
- Orally bioavailable with demonstrated in vivo antitumor efficacy.
- Documented cellular activity in multiple cancer cell lines.
- High purity and characterized molecular weight and formula.
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Medchemexpress LLC N-benzyl-N-butyl-4-(phenylsulfamoyl)benzamide | 2244678-29-1 | 98.4% | 50 MG
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TH-257 (CAS 2244678-29-1) is a small-molecule allosteric inhibitor of LIM kinase 1 and 2 used as a biochemical research probe to study LIMK-mediated signaling pathways in vitro.
- Potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM.
- Molecular formula C24H26N2O3S and molecular weight 422.54 g/mol.
- High purity (98.36%) suitable for in vitro biochemical studies.
- Supplied as a solid powder and as a 10 mM solution in DMSO; common pack sizes include 5 mg, 10 mg, 50 mg, and 100 mg.
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Selleck Chemical LLC (R)-Nepicastat HCl S4926-10mg
(R)-Nepicastat HCl (RS-25560-198) the R-enantiomer of Nepicastat HCl is a potent and selective inhibitor with IC50 of 25 1 nM and 18 3 nM for bovine and human dopamine- -hydroxylase with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors
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Medchemexpress LLC YL-939 | 3023925-68-7 | 99.0% | 426.51 g/mol | C25H26N6O | 10 MG
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YL-939 is a small-molecule ferroptosis inhibitor that prevents iron-dependent cell death by modulating the PHB2/ferritin/iron axis. It has been characterized as a non-classical ferroptosis inhibitor with demonstrated protective activity in cellular assays.
- Inhibits ferroptosis via the PHB2/ferritin/iron axis.
- Demonstrated cellular activity in vitro against ferroptotic insults.
- High chemical purity (~99.0%) and defined physical properties.
- Off-white to light-yellow solid, molecular weight 426.51 g/mol.
- CAS number 3023925-68-7 for unambiguous identification.
- Soluble in DMSO (100 mg/mL) and amenable to in vivo formulations.
- Store as powder at -20°C; limited stability in solution.
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 10 MG
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JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK variants, including those with resistance mutations, and shows selectivity against other kinases. This compound inhibits the growth of several cancer cell lines and exhibits good oral bioavailability, with the ability to penetrate the central nervous system in mice.
- Potent inhibitor of EML4-ALK variants, including G1202R resistance mutation
- Selective against various other kinases such as IRAK1, CLK4, and RET
- Inhibits the growth of cancer cell lines like H3122 and DFCI76
- Good oral bioavailability in mice
- Penetrates the central nervous system in mice
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Medchemexpress LLC Blue Tetrazolium | 1871-22-3 | MFCD00040933 | 99.8% | 100 MG
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Blue Tetrazolium is a blue dye used in microbial research that can be reduced into blue tetrazolium formazan (BTF). It acts as a substrate to determine the activity of succinate dehydrogenase (SDH) in yeast strains. BTF can be extracted from cells using DMSO, and its absorption spectrum can be analyzed with a broad wavelength range of 480-600 nm, and a maximal absorbance at 540 nm.
- Used as a blue dye in microbial research.
- Reducible to blue tetrazolium formazan (BTF).
- Determines succinate dehydrogenase (SDH) activity in yeast strains.
- Absorption spectrum of BTF shows maximal absorbance at 540 nm.
- Functions as a novel corrosion inhibitor for cold-rolled steel in hydrochloric acid solutions.
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Medchemexpress LLC Tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | 571188-59-5 | 99.97% | 278.36 | 50 G
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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a drug intermediate used for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Drug intermediate
- For synthesis of various active compounds
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eMolecules 1251929-90-4 | 2-hydroxy-2-(4-methylthiazol-2-yl)propanehydrazide | 250mg
Pharmablock | O3-tert-butyl O8-methyl 3-azabicyclo[3.2.1]octane-38-dicarboxylate | 25mg | 590288775 | PBLG0009 | 1403766-87-9 | MFCD23106312 | 269.341 | C14H23NO4
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eMolecules 71574-33-9 | 4,5-Dimethylthiazol-2-amine hydrochloride | Oakwood Chemical | MFCD00012711 | 164.650 | C5H9ClN2S | 98.000 | Cl.Cc1nc(N)sc1C | 1g | 537714270
4,5-Dimethylthiazol-2-amine hydrochloride | Oakwood Chemical | 71574-33-9 | MFCD00012711 | 164.650 | C5H9ClN2S | 98.000 | Cl.Cc1nc(N)sc1C | 1g | 537714270
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Medchemexpress LLC N-benzyl-4-(N-benzylsulfamoyl)benzamide | 313520-94-4 | MFCD00990583 | 99.0% | C21H20N2O3S | 10MG
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TH-263 is a diaryl sulfonamide derivative (CAS 313520-94-4) that is inactive toward both LIMK1 and LIMK2 and is used as a negative control for the LIMK inhibitor TH-257. It is supplied as a high-purity solid (molecular formula C21H20N2O3S, MW 380.46 g/mol), soluble in DMSO, and intended for use as a selectivity control in biochemical and cell-based assays.
- Diaryl sulfonamide derivative inactive toward LIMK1 and LIMK2.
- High purity: 99.0%.
- Suitable as a negative control in biochemical and cell-based assays.
- Soluble in DMSO for in vitro applications.
- Powder stable at -20°C; solutions stored at -80°C for extended stability.
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