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Filtered Search Results
Apexbio Technology LLC TH-302 918633-87-1 200mg
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TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
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Medchemexpress LLC MET kinase-IN-4 | 888719-03-7 | 99.0% | 458.42 | 25 MG
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MET kinase-IN-4 is an orally active Met kinase inhibitor with potent Met kinase inhibitory activity (IC50 value of 1.9 nM). It can be used for cancer research. It also inhibits Flt-3 and VEGFR-2 kinases with IC50 values of 4 nM and 27 nM, respectively. MET kinase-IN-4 (3 μM) shows good metabolic stability in both human and mouse liver microsomes.
- Orally active Met kinase inhibitor.
- Potent Met kinase inhibitory activity with an IC50 value of 1.9 nM.
- Inhibits Flt-3 and VEGFR-2 kinases with IC50 values of 4 nM and 27 nM, respectively.
- Shows good metabolic stability in both human and mouse liver microsomes.
- Possesses a favorable pharmacokinetic profile in mice.
- Demonstrates significant in vivo antitumor activity in the GTL-16 human gastric carcinoma xenograft model.
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eMolecules 42014-51-7 | 2,5-dioxopyrrolidin-1-yl 2-bromoacetate | Absolute Chiral | MFCD00058571 | 236.021 | C6H6BrNO4 | 95.000 | BrCC(=O)ON1C(=O)CCC1=O | 1g | 345476321
2,5-dioxopyrrolidin-1-yl 2-bromoacetate | Absolute Chiral | 42014-51-7 | MFCD00058571 | 236.021 | C6H6BrNO4 | 95.000 | BrCC(=O)ON1C(=O)CCC1=O | 1g | 345476321
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eMolecules 68181-17-9 | 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate | Abosyn Chemicals Inc. | MFCD00009636 | 312.360 | C12H12N2O4S2 | 0.000 | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O | 10g | 812069150
2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate | Abosyn Chemicals Inc. | 68181-17-9 | MFCD00009636 | 312.360 | C12H12N2O4S2 | 0.000 | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O | 10g | 812069150
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eMolecules 68181-17-9 | 2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate | Abosyn Chemicals Inc. | MFCD00009636 | 312.360 | C12H12N2O4S2 | 0.000 | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O | 5g | 812069149
2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoate | Abosyn Chemicals Inc. | 68181-17-9 | MFCD00009636 | 312.360 | C12H12N2O4S2 | 0.000 | O=C(CCSSc1ccccn1)ON1C(=O)CCC1=O | 5g | 812069149
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eMolecules 585-48-8 | 2,6-Di-tert-butylpyridine | Chem-Impex | MFCD00006306 | 191.318 | C13H21N | 99.000 | CC(C)(C)c1cccc(n1)C(C)(C)C | 25g | 489819715
2,6-Di-tert-butylpyridine | Chem-Impex | 585-48-8 | MFCD00006306 | 191.318 | C13H21N | 99.000 | CC(C)(C)c1cccc(n1)C(C)(C)C | 25g | 489819715
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eMolecules 75824-03-2 | Ethyl 5-Chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate | Accela ChemBio | MFCD09953614 | 233.670 | C7H8ClN3O2S | 95.000 | CCOC(=O)c1nnc(SC)nc1Cl | 10g | 772325344
Ethyl 5-Chloro-3-(methylthio)-1,2,4-triazine-6-carboxylate | Accela ChemBio | 75824-03-2 | MFCD09953614 | 233.670 | C7H8ClN3O2S | 95.000 | CCOC(=O)c1nnc(SC)nc1Cl | 10g | 772325344
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eMolecules 66493-39-8 | 4-tert-Butoxycarbonylamino-benzoic acid | Oakwood Chemicals | MFCD00037428 | 237.255 | C12H15NO4 | 97.000 | CC(C)(C)OC(=O)Nc1ccc(cc1)C(O)=O | 250mg | 486552293
4-tert-Butoxycarbonylamino-benzoic acid | Oakwood Chemicals | 66493-39-8 | MFCD00037428 | 237.255 | C12H15NO4 | 97.000 | CC(C)(C)OC(=O)Nc1ccc(cc1)C(O)=O | 250mg | 486552293
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eMolecules 771-14-2 | 2-bromonaphthalen-1-amine | Pharmablock | MFCD11870111 | 222.085 | C10H8BrN | 97.000 | Nc1c(Br)ccc2ccccc12 | 500mg | 665627061
2-bromonaphthalen-1-amine | Pharmablock | 771-14-2 | MFCD11870111 | 222.085 | C10H8BrN | 97.000 | Nc1c(Br)ccc2ccccc12 | 500mg | 665627061
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eMolecules 57159-62-3 | 2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate | Absolute Chiral | MFCD01863457 | 307.100 | C9H11BrN2O5 | 95.000 | BrCC(=O)NCCC(=O)ON1C(=O)CCC1=O | 100mg | 380243899
2,5-dioxopyrrolidin-1-yl 3-(2-bromoacetamido)propanoate | Absolute Chiral | 57159-62-3 | MFCD01863457 | 307.100 | C9H11BrN2O5 | 95.000 | BrCC(=O)NCCC(=O)ON1C(=O)CCC1=O | 100mg | 380243899
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(C)C#C | 1g | 862834192](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000472398.jpg-250.jpg)
eMolecules 86318-61-8 | (tert-Butyldimethylsilyl)acetylene | AA Blocks LLC | MFCD00191877 | 140.301 | C8H16Si | 0.000 | CC(C)(C)[Si](C)(C)C#C | 1g | 862834192
(tert-Butyldimethylsilyl)acetylene | AA Blocks LLC | 86318-61-8 | MFCD00191877 | 140.301 | C8H16Si | 0.000 | CC(C)(C)[Si](C)(C)C#C | 1g | 862834192
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(C)CCOC(=O)ON1C(=O)CCC1=O | 5g | 480163329](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000473708.jpg-250.jpg)
eMolecules 78269-85-9 | 2,5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)ethyl) carbonate | Oakwood Chemicals | MFCD02683467 | 259.333 | C10H17NO5Si | 96.000 | C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O | 5g | 480163329
2,5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)ethyl) carbonate | Oakwood Chemicals | 78269-85-9 | MFCD02683467 | 259.333 | C10H17NO5Si | 96.000 | C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O | 5g | 480163329
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(C)CCOC(=O)ON1C(=O)CCC1=O | 100g | 480163331](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000473710.jpg-250.jpg)
eMolecules 78269-85-9 | 2,5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)ethyl) carbonate | Oakwood Chemicals | MFCD02683467 | 259.333 | C10H17NO5Si | 96.000 | C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O | 100g | 480163331
2,5-Dioxopyrrolidin-1-yl (2-(trimethylsilyl)ethyl) carbonate | Oakwood Chemicals | 78269-85-9 | MFCD02683467 | 259.333 | C10H17NO5Si | 96.000 | C[Si](C)(C)CCOC(=O)ON1C(=O)CCC1=O | 100g | 480163331
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![eMolecules 548762-66-9 | tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 25g | 761955091](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000471225.jpg-250.jpg)
eMolecules 548762-66-9 | tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 25g | 761955091
tert-butyl(2S,5R)-2,5-dimethylpiperazine-1-carboxylate | Synthonix | 548762-66-9214.309 | C11H22N2O2 | 98.000 | C[C@@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C | 25g | 761955091
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![eMolecules 95408-45-0 | 1,1'-Bis(di-tert-butylphosphino)ferrocene Palladium Dichloride | Accela ChemBio (ASD) | MFCD08064219 | 651.750 | C26H44Cl2FeP2Pd | 98.000 | [Cl-].[Cl-].[Fe].[Pd++].CC(C)(C)P(c1cccc1)C(C)(C)C.CC(C)(C)P(c1cccc1)C(C)(C)C | 10g | 510407147](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000483578.jpg-250.jpg)
eMolecules 95408-45-0 | 1,1'-Bis(di-tert-butylphosphino)ferrocene Palladium Dichloride | Accela ChemBio (ASD) | MFCD08064219 | 651.750 | C26H44Cl2FeP2Pd | 98.000 | [Cl-].[Cl-].[Fe].[Pd++].CC(C)(C)P(c1cccc1)C(C)(C)C.CC(C)(C)P(c1cccc1)C(C)(C)C | 10g | 510407147
1,1'-Bis(di-tert-butylphosphino)ferrocene Palladium Dichloride | Accela ChemBio (ASD) | 95408-45-0 | MFCD08064219 | 651.750 | C26H44Cl2FeP2Pd | 98.000 | [Cl-].[Cl-].[Fe].[Pd++].CC(C)(C)P(c1cccc1)C(C)(C)C.CC(C)(C)P(c1cccc1)C(C)(C)C | 10g | 510407147
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