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Filtered Search Results
Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 100 MG
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JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It exhibits an IC50 of 2 nM for EML4-ALK G1202R in cells and potently inhibits various other EML4-ALK mutants and wild type (e.g., EML4-ALKwt, EAC1156Y, EAF1174L, EAS1206Y with IC50s of 2-196 nM). It shows selectivity at other kinases like IRAK1, CLK4, RET, and IRAK 4. JH-VIII-157-02 demonstrates inhibitory growth against cancer cell lines like H3122 and DFCI76 (EC50s of 5 nM and 19 nM). It also has good oral bioavailability and penetrates the CNS in mice.
- Structural analogue of alectinib
- Acts as an ALK inhibitor
- Shows potent inhibition of EML4-ALK G1202R mutant (IC50 of 2 nM)
- Potently inhibits other EML4-ALK mutants and wild type
- Exhibits selectivity at several other kinases
- Inhibits growth of cancer cell lines
- Good oral bioavailability in mice
- Penetrates the CNS of mice
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 50 MG
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JH-VIII-157-02 is a structural analogue of alectinib and functions as an Anaplastic Lymphoma Kinase (ALK) inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK mutations and shows selectivity at other kinases. The compound also exhibits inhibitory growth against several cancer cell lines and good oral bioavailability in vivo.
- Potent ALK inhibitor
- Inhibits various EML4-ALK mutations
- Selective inhibition against kinases such as IRAK1, CLK4, and RET
- Inhibits growth of cancer cell lines like H3122 and DFCI76 (L1152R)
- Good oral bioavailability and CNS penetration
- Soluble in DMSO at concentrations ≥ 25 mg/mL
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Medchemexpress LLC HZX-02-059 | 2240205-30-3 | 99.4% | 487.48 | 25 MG
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HZX-02-059 is a potent methuosis inducer and dual-target PIKfyve/tubulin inhibitor with anticancer activity. It primarily disrupts the balance of endocytosis and exocytosis, leading to the formation of numerous vesicles and inducing cell death. This compound also induces cell vacuolization, promotes apoptosis, downregulates the p53 pathway, inhibits PI3K/AKT phosphorylation, and suppresses c-Myc and NF-κB transcription.
- Potent methuosis inducer
- Dual-target PIKfyve/tubulin inhibitor
- Anticancer activity
- Induces cell vacuolization
- Promotes apoptosis
- Downregulates the p53 pathway
- Inhibits PI3K/AKT phosphorylation
- Inhibits c-Myc and NF-κB transcription
- Broad spectrum of cytotoxicity against various human cancer cell lines
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Medchemexpress LLC α-Methyltyrosine methyl ester hydrochloride | 7361-31-1 | 98.91% | 245.71 | 1 G
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α-Methyltyrosine methyl ester hydrochloride is an orally active, competitive tyrosine hydroxylase inhibitor. It can inhibit the conversion of tyrosine to dopamine and serves as a tool for sympathetic nervous system research. Studies have shown it can induce renal lesions with the formation of calculi in the urinary tract in rats.
- Orally active and competitive tyrosine hydroxylase inhibitor
- Inhibits the conversion of tyrosine to dopamine
- Can be used as a tool for sympathetic nervous system research
- Induces renal lesions with the formation of calculi in the urinary tract in rats
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eMolecules 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | 185040-35-1 | MFCD12911523 | 1g
Combi-Blocks | 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | 1g | 457916227 | QY-3265 | 98.000 | 185040-35-1 | MFCD12911523 | 197.260 | C8H11N3OS
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Sigma Aldrich Fine Chemicals Biosciences 245-Trimethylthiazole 98 f100G
2 4 5-Trimethylthiazole is a sulfur-containing heterocyclic compound mainly found in meat products such as chicken broth cooked beef and roasted lamb fat.
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Medchemexpress LLC Gamma-Linolenic acid methyl ester | 16326-32-2 | 99.37% | 292.46 | 50 MG
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Gamma-Linolenic acid methyl ester | 16326-32-2 | 99.37% | 292.46 | 50 MG
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Medchemexpress LLC Pomalidomide-5-C10-NH2 hydrochloride | 2863635-00-9 | 95.0% | 464.99 | C23H33ClN4O4 | 10 MG
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Pomalidomide-5-C10-NH2 hydrochloride is a pomalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use in targeted protein degradation research. It is intended as a building block for PROTAC synthesis and related biochemical studies, provided in small research quantities with defined purity and molecular properties.
- Acts as a cereblon E3 ligase recruiter for PROTAC design.
- Provided as the hydrochloride salt for improved stability and handling.
- Offered in small-milligram quantities suitable for medicinal chemistry work.
- Characterized by specified purity and molecular weight for reproducible results.
- Compatible with standard organic solvents used in synthesis and assays.
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Cell Signaling Technology TREM2 (E6T1P) Rabbit mAb (Amino-terminal Antigen) 20 ul
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TREM2 (E6T1P) Rabbit mAb (Amino-terminal Antigen) 20 ul
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Medchemexpress LLC N-(Benzotriazol-1-ylmethyl)-N-benzyl-1-phenylmethanamine | 57684-32-9 | 95.0% | 328.42 | 5 G
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N-(Benzotriazol-1-ylmethyl)-N-benzyl-1-phenylmethanamine is a drug intermediate for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Drug intermediate for synthesis
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Chem-Impex International, Inc. 1-(2-Amino-4-methyl-1,3-thiazol-5-yl)ethanone | MFCD00051952 | 25G
1-(2-Amino-4-methyl-1,3-thiazol-5-yl)ethanone, MFCD00051952, 25G
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eMolecules Oakwood Chemical 3-tert-Butoxycarbonylbenzeneboronic acid 250mg 795593341 065582 0 000 220210-56-0 MFCD01630855 222 050 C11H15BO4
Oakwood Chemical 3-tert-Butoxycarbonylbenzeneboronic acid 250mg 795593341 065582 0 000 220210-56-0 MFCD01630855 222 050 C11H15BO4
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![Medchemexpress LLC N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide | 593960-11-3 | >98.0% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231848.png-250.jpg)
Medchemexpress LLC N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide | 593960-11-3 | >98.0% | 100 MG
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PIK-93 is a small-molecule kinase inhibitor used in research to inhibit PI4KIIIβ and certain PI3K isoforms. It is reported to inhibit PI4KIIIβ with an IC50 of 19 nM, PI3Kγ with an IC50 of 16 nM, and PI3Kα with an IC50 of 39 nM.
- Potent PI4KIIIβ inhibitor; IC50 = 19 nM.
- Also inhibits PI3Kγ (IC50 = 16 nM) and PI3Kα (IC50 = 39 nM).
- Chemical formula C14H16ClN3O4S2; molecular weight 389.9 g/mol.
- Typically supplied as a solid for research applications.
- Purity commonly reported ≥98% by suppliers.
- Useful for studies of PI4K/PI3K signaling and viral replication pathways.
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Medchemexpress LLC α-Methyltyrosine methyl ester hydrochloride | 7361-31-1 | MFCD00012606 | 98.9% | 245.71 | 5 G
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α-Methyltyrosine methyl ester hydrochloride is an orally active and competitive tyrosine hydroxylase inhibitor. It can inhibit the conversion of tyrosine to dopamine. It causes kidney damage and urethral calculi in rats and can be used as a tool for sympathetic nervous system research.
- Orally active
- Competitive tyrosine hydroxylase inhibitor
- Inhibits the conversion of tyrosine to dopamine
- Can be used as a tool for sympathetic nervous system research
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BIOHIPPO AAV-TH-Flp-WPRE-hGH-polyA
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Recombinant adeno associated virus expressing Flp under the TH promoter with WPRE and hGH polyA elements. The Flp dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
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