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Filtered Search Results
Medchemexpress LLC A-METHYLTYROSINE MET 250MG | 250MG
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A-METHYLTYROSINE MET 250MG | 250MG
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![eMolecules AstaTech / TERT-BUTYL 4-(4-METHYLTHIAZOL-5-YL)BENZYLCARBAMATE / 0.25g / 696744636 / E71371 / 95.000 / 2308507-34-6 / [null] / 304.410 / C16H20N2O2S](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502469878.JPG-250.jpg)
eMolecules AstaTech / TERT-BUTYL 4-(4-METHYLTHIAZOL-5-YL)BENZYLCARBAMATE / 0.25g / 696744636 / E71371 / 95.000 / 2308507-34-6 / [null] / 304.410 / C16H20N2O2S
AstaTech / TERT-BUTYL 4-(4-METHYLTHIAZOL-5-YL)BENZYLCARBAMATE / 0.25g / 696744636 / E71371 / 95.000 / 2308507-34-6 / [null] / 304.410 / C16H20N2O2S
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Apexbio Technology LLC TH-302 918633-87-1 5mg
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TH-302 (CAS 918633-87-1) is a hypoxia-activated prodrug comprising a 2-nitroimidazole moiety linked to a brominated isophosphoramide mustard Under severe hypoxic conditions (approximately 0 1% O ) TH-302 undergoes bioreductive activation releasing the cytotoxic alkylating agent Br-IPM selectively within hypoxic tumor microenvironments In vitro studies demonstrate markedly increased cytotoxicity against tumor cell lines under hypoxia with IC50 values ranging from 0 1 to 0 8 M for H460 Caki-1 SK-MEL-5 DU145 and HCT116 cells while IC50 values exceed 40 M in normoxic conditions In H460 xenograft mouse models TH-302 induces dose-dependent tumor growth inhibition without hematological toxicity and increases H2AX-positive cells indicating DNA damage TH-302 is utilized to investigate tumor hypoxia-targeting therapies and mechanisms of selective cytotoxicity
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Medchemexpress LLC (2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone | 141645-16-1 | 99.57% | C19H17NO5 | 25 G
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(2-Butyl-5-nitrobenzofuran-3-yl)(4-hydroxyphenyl)methanone is a drug intermediate used for the synthesis of various active compounds. This product is for research use only and not intended for patient administration.
- Drug intermediate for various active compound syntheses
- High purity: 99.57%
- For research use only
- Solid appearance
- Off-white to yellow color
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Medchemexpress LLC TH-6 | 3031349-25-1 | 95.0% | 429.44 | 5 MG
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TH-6 is a potent HDAC inhibitor that targets HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8. This compound has demonstrated anti-tumor activity by inhibiting cell migration and invasion, and inducing apoptosis and cell cycle arrest at the G2/M phase.
- Potent HDAC inhibitor
- Inhibits cell migration and invasion
- Induces apoptosis
- Induces cell cycle arrest at G2/M phase
- Demonstrates anti-tumor activity
- For research use only
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Medchemexpress LLC (S,R,S)-AHPC-C10-NHBoc | 2412055-13-9 | 98.3% | 713.97 | 25 MG
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(S,R,S)-AHPC-C10-NHBoc is a synthesized E3 ligase ligand-linker conjugate. It incorporates the (S,R,S)-AHPC based VHL ligand and a linker, used for BET-Targeted PROTAC technology. This product is intended for laboratory research and the manufacture of substances.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates (S,R,S)-AHPC based VHL ligand
- Utilized in BET-Targeted PROTAC technology
- For research use only, not fully validated for medical applications
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Medchemexpress LLC YL-939 | 3023925-68-7 | C25H26N6O | 100 MG
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YL-939 is a potent ferroptosis inhibitor. It inhibits ferroptosis by targeting the PHB2/ferritin/iron axis.
- Efficiently protects cells from ferroptosis with varying IC50 values across different cell lines.
- Reduces the level of reactive oxygen species in cytosolic and membrane lipids.
- Improves ferritin protein expression and blocks autophagosomes/lysosomes, inhibiting ferritinophagy.
- Ameliorates liver damage in an acetaminophen-induced acute liver injury model.
- Inhibits cell death and inflammatory infiltration in liver tissues.
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Medchemexpress LLC Yl-939 | 3023925-68-7 | C25H26N6O | 1 ML
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YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis with IC50 values ranging from 0.14 μM to 0.25 μM for various cell lines. It also reduces the level of reactive oxygen species (ROS) in cytosolic and membrane lipids.
- Ameliorates liver damage in an acetaminophen-induced acute liver injury mouse model.
- Inhibits cell death and inflammatory infiltration in liver tissues.
- Improves ferritin protein expression in a concentration-dependent manner.
- Blocks autophagosomes/lysosomes, inhibiting ferritinophagy.
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Medchemexpress LLC 93-O17S | 2227008-67-3 | C44H83N3O4S2 | 25 MG
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93-O17S is an ionizable lipid involved in the construction of Lipid Nanoparticles (LNP) and can achieve mRNA delivery to the spleen. This product is for research use only.
- Ionizable lipid
- Involved in the construction of lipid nanoparticles (LNP)
- Achieves mRNA delivery to the spleen
- Delivers luciferase mRNA to the spleen of mice
- Purity: 98.0%
- Appearance: Oil
- Color: Light yellow to yellow
- Soluble in DMSO and ethanol
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Medchemexpress LLC TH-Z93 | 2260887-09-8 | C12H22N2O7P2 | 5 MG
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TH-Z93 is a lipophilic bisphosphonate that acts as an FPPS inhibitor with an IC50 of 90 nM. It exhibits strong prophylactic effects in a pathogenic influenza model, inhibiting tumor growth and prolonging survival in a B16-OVA cells (s.c.) xenograft mice model. It is for research use only.
- FPPS inhibitor with an IC50 of 90 nM
- Exhibits strong prophylactic effects in pathogenic influenza model
- Inhibits tumor growth and prolongs survival in xenograft mice model
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Medchemexpress LLC KN-93 | 139298-40-1 | C26H29ClN2O4S | 25 MG
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KN-93 is a cell-permeable, reversible, and competitive inhibitor of calmodulin-dependent kinase type II (CaMKII) with a Ki of 370 nM. It is for research use only.
- Cell-permeable, reversible, and competitive inhibitor of CaMKII
- Ki of 370 nM
- High purity of 99.42%
- Appears as a white to off-white solid
- Blocks cell growth stimulated by growth factors
- Inhibits H+, K+-ATPase activity
- Inhibits activation of CaMKII/NF-κB signaling
- Inhibits retinal vascular leakage in diabetic models
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Medchemexpress LLC Th-Z145 | 2260887-57-6 | C16H28O7P2 | 5 MG
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TH-Z145 is a lipophilic bisphosphonate that acts as an FPPS inhibitor. It has demonstrated strong prophylactic effects in a pathogenic influenza model and inhibited tumor growth in a xenograft mice model. It appears as an off-white to light yellow solid with a purity of 99.69%.
- FPPS inhibitor with an IC50 of 210 nM
- Demonstrated strong prophylactic effects in pathogenic influenza model
- Inhibited tumor growth and prolonged survival in xenograft mice model
- Soluble in DMSO at 100 mg/mL
- Purity of 99.69%
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Medchemexpress LLC C14H11NO2S | 36341-25-0 | 99.3% | 257.31 | 50 MG
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YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. It has the ability to inhibit breast cancer cell growth and invasiveness.
- Inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
- Increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
- Inhibits tumor growth and cancer metastasis of breast cancer cells in vivo.
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Medchemexpress LLC YL-109 | 36341-25-0 | 99.3% | 257.31 | 1 ML
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YL-109 is an antitumor agent that works by inducing carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. It has demonstrated the ability to inhibit breast cancer cell growth and invasiveness.
- Inhibits cell proliferation, motility, and invasiveness in breast cancer cells
- Increases CHIP mRNA and protein levels
- Suppresses tumor growth and cancer metastasis in vivo
- Strongly inhibited cell proliferation in MCF-7 and MDA-MB-231 cells
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Medchemexpress LLC (S)-2-Amino-3,3-diphenylpropanoic acid | 149597-92-2 | 241.29 | 25 G
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(S)-2-Amino-3,3-diphenylpropanoic acid is an alanine derivative commercially used as an ergogenic supplement. It influences the secretion of anabolic hormones, supplies fuel during exercise, enhances mental performance during stress-related tasks, and helps prevent exercise-induced muscle damage. It is recognized as a beneficial ergogenic dietary substance.
- Alanine derivative
- Influences anabolic hormone secretion
- Supplies fuel during exercise
- Enhances mental performance during stress
- Helps prevent exercise-induced muscle damage
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