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Filtered Search Results
Medchemexpress LLC 1,2:5,6-Bis-O-(1-methylethylidene)-α-D-allofuranose | 2595-05-3 | 260.29 | 100 G
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1,2:5,6-Bis-O-(1-methylethylidene)-α-D-allofuranose is a biochemical reagent used in glycobiology research. This field investigates the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycan formation and degradation enzymology, protein-glycan recognition, and the role of glycans in biological systems. It is closely related to basic research, biomedicine, and biotechnology.
- White to off-white solid
- Purity of ≥98.0% (NMR)
- ¹H NMR spectrum consistent with structure
- Used in glycobiology research
- Supports studies in carbohydrate chemistry and glycan enzymology
- Aids in protein-glycan recognition research
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Medchemexpress LLC Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate | 179003-02-2 | 279.34 | 25 G
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Methyl 3-(2-((tert-butoxycarbonyl)amino)ethyl)benzoate is a versatile drug intermediate used in the synthesis of various active compounds. This chemical plays a crucial role in pharmaceutical research and development.
- Serves as a key building block for synthesizing active pharmaceutical ingredients
- Utilized in advanced chemical synthesis processes
- Applicable in drug discovery and development
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Medchemexpress LLC 2-Hydroxy-4-methylth 100g | 583-91-5 | 100 G
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2-Hydroxy-4-(methylthio)butyric acid is an alpha-hydroxy derivative of methionine supplied for laboratory research use. It is commonly used in biochemical studies and animal nutrition research and is provided with supporting documentation for safe handling and quality verification.
- For research use only; not for human consumption or clinical use.
- Packaged as a 100 g package; other sizes are available.
- Purity ≥88.0% as supplied.
- Molecular formula C5H10O3S; molecular weight 150.20 g/mol.
- Safety data sheet and certificate of analysis available.
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 100 MG
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JH-VIII-157-02 is a structural analogue of alectinib, functioning as an ALK inhibitor. It exhibits an IC50 of 2 nM for EML4-ALK G1202R in cells and potently inhibits various other EML4-ALK mutants and wild type (e.g., EML4-ALKwt, EAC1156Y, EAF1174L, EAS1206Y with IC50s of 2-196 nM). It shows selectivity at other kinases like IRAK1, CLK4, RET, and IRAK 4. JH-VIII-157-02 demonstrates inhibitory growth against cancer cell lines like H3122 and DFCI76 (EC50s of 5 nM and 19 nM). It also has good oral bioavailability and penetrates the CNS in mice.
- Structural analogue of alectinib
- Acts as an ALK inhibitor
- Shows potent inhibition of EML4-ALK G1202R mutant (IC50 of 2 nM)
- Potently inhibits other EML4-ALK mutants and wild type
- Exhibits selectivity at several other kinases
- Inhibits growth of cancer cell lines
- Good oral bioavailability in mice
- Penetrates the CNS of mice
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Medchemexpress LLC JH-VIII-157-02 | 1639422-97-1 | 99.0% | 465.55 | 50 MG
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JH-VIII-157-02 is a structural analogue of alectinib and functions as an Anaplastic Lymphoma Kinase (ALK) inhibitor. It demonstrates potent inhibitory activity against various EML4-ALK mutations and shows selectivity at other kinases. The compound also exhibits inhibitory growth against several cancer cell lines and good oral bioavailability in vivo.
- Potent ALK inhibitor
- Inhibits various EML4-ALK mutations
- Selective inhibition against kinases such as IRAK1, CLK4, and RET
- Inhibits growth of cancer cell lines like H3122 and DFCI76 (L1152R)
- Good oral bioavailability and CNS penetration
- Soluble in DMSO at concentrations ≥ 25 mg/mL
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Medchemexpress LLC HZX-02-059 | 2240205-30-3 | 99.4% | 487.48 | 25 MG
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HZX-02-059 is a potent methuosis inducer and dual-target PIKfyve/tubulin inhibitor with anticancer activity. It primarily disrupts the balance of endocytosis and exocytosis, leading to the formation of numerous vesicles and inducing cell death. This compound also induces cell vacuolization, promotes apoptosis, downregulates the p53 pathway, inhibits PI3K/AKT phosphorylation, and suppresses c-Myc and NF-κB transcription.
- Potent methuosis inducer
- Dual-target PIKfyve/tubulin inhibitor
- Anticancer activity
- Induces cell vacuolization
- Promotes apoptosis
- Downregulates the p53 pathway
- Inhibits PI3K/AKT phosphorylation
- Inhibits c-Myc and NF-κB transcription
- Broad spectrum of cytotoxicity against various human cancer cell lines
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Medchemexpress LLC α-Methyltyrosine methyl ester hydrochloride | 7361-31-1 | 98.91% | 245.71 | 1 G
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α-Methyltyrosine methyl ester hydrochloride is an orally active, competitive tyrosine hydroxylase inhibitor. It can inhibit the conversion of tyrosine to dopamine and serves as a tool for sympathetic nervous system research. Studies have shown it can induce renal lesions with the formation of calculi in the urinary tract in rats.
- Orally active and competitive tyrosine hydroxylase inhibitor
- Inhibits the conversion of tyrosine to dopamine
- Can be used as a tool for sympathetic nervous system research
- Induces renal lesions with the formation of calculi in the urinary tract in rats
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eMolecules 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | 185040-35-1 | MFCD12911523 | 1g
Combi-Blocks | 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde | 1g | 457916227 | QY-3265 | 98.000 | 185040-35-1 | MFCD12911523 | 197.260 | C8H11N3OS
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Sigma Aldrich Fine Chemicals Biosciences 245-Trimethylthiazole 98 f100G
2 4 5-Trimethylthiazole is a sulfur-containing heterocyclic compound mainly found in meat products such as chicken broth cooked beef and roasted lamb fat.
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Medchemexpress LLC Gamma-Linolenic acid methyl ester | 16326-32-2 | 99.37% | 292.46 | 50 MG
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Gamma-Linolenic acid methyl ester | 16326-32-2 | 99.37% | 292.46 | 50 MG
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Medchemexpress LLC Pomalidomide-5-C10-NH2 hydrochloride | 2863635-00-9 | 95.0% | 464.99 | C23H33ClN4O4 | 10 MG
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Pomalidomide-5-C10-NH2 hydrochloride is a pomalidomide-derived cereblon (CRBN) ligand supplied as the hydrochloride salt for use in targeted protein degradation research. It is intended as a building block for PROTAC synthesis and related biochemical studies, provided in small research quantities with defined purity and molecular properties.
- Acts as a cereblon E3 ligase recruiter for PROTAC design.
- Provided as the hydrochloride salt for improved stability and handling.
- Offered in small-milligram quantities suitable for medicinal chemistry work.
- Characterized by specified purity and molecular weight for reproducible results.
- Compatible with standard organic solvents used in synthesis and assays.
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Medchemexpress LLC Blue Tetrazolium | 1871-22-3 | 99.8% | 1 G
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Blue Tetrazolium is a blue dye used in microbial research. It can be reduced into blue tetrazolium formazan (BTF) and is suitable for determining the activity of succinate dehydrogenase (SDH) in yeast strains. The BTF can be extracted from cells using DMSO, and its absorption spectrum can be tested, showing a wide wavelength range of 480-600 nm with maximal absorbance at 540 nm.
- Blue dye for microbial research.
- Can be reduced into blue tetrazolium formazan (BTF).
- Used to determine the activity of succinate dehydrogenase (SDH) in yeast strains.
- BTF exhibits a wide wavelength range of 480-600 nm with maximal absorbance at 540 nm.
- Combines with succinate dehydrogenase (SDH).
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Medchemexpress LLC N-(Benzotriazol-1-ylmethyl)-N-benzyl-1-phenylmethanamine | 57684-32-9 | 95.0% | 328.42 | 5 G
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N-(Benzotriazol-1-ylmethyl)-N-benzyl-1-phenylmethanamine is a drug intermediate for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Drug intermediate for synthesis
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eMolecules Oakwood Chemical 3-tert-Butoxycarbonylbenzeneboronic acid 250mg 795593341 065582 0 000 220210-56-0 MFCD01630855 222 050 C11H15BO4
Oakwood Chemical 3-tert-Butoxycarbonylbenzeneboronic acid 250mg 795593341 065582 0 000 220210-56-0 MFCD01630855 222 050 C11H15BO4
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![Medchemexpress LLC N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide | 593960-11-3 | >98.0% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231848.png-250.jpg)
Medchemexpress LLC N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide | 593960-11-3 | >98.0% | 100 MG
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PIK-93 is a small-molecule kinase inhibitor used in research to inhibit PI4KIIIβ and certain PI3K isoforms. It is reported to inhibit PI4KIIIβ with an IC50 of 19 nM, PI3Kγ with an IC50 of 16 nM, and PI3Kα with an IC50 of 39 nM.
- Potent PI4KIIIβ inhibitor; IC50 = 19 nM.
- Also inhibits PI3Kγ (IC50 = 16 nM) and PI3Kα (IC50 = 39 nM).
- Chemical formula C14H16ClN3O4S2; molecular weight 389.9 g/mol.
- Typically supplied as a solid for research applications.
- Purity commonly reported ≥98% by suppliers.
- Useful for studies of PI4K/PI3K signaling and viral replication pathways.
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