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Thiazoles

Organic heterocyclic compounds that consist of an azole with both sulfur and nitrogen atoms; includes compounds that are derived from thiazoles.

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zinc

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1

Sigma Aldrich Fine Chemicals Biosciences Zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine Dye content 90 % | Purity: 88.5% (HPLC) | Mol Wt: 682.06 | 31183-11-6 | MFCD00274658 | 1G

Zinc 5,10,15,20-tetra(4-pyridyl)-21H,23H-porphine Dye content 90 % | Purity: 88.5% (HPLC) | Mol Wt: 682.06 | 31183-11-6 | MFCD00274658 | 1G

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2

Apexbio Technology LLC AGI-5198 1355326-35-0 25mg
SDP

AGI-5198 (CAS 1355326-35-0) is a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) harboring the R132H substitution Identified via high-throughput screening AGI-5198 blocks mutant IDH1-mediated formation of the oncometabolite R-2-hydroxyglutarate (R-2-HG) in a dose-dependent manner Mechanistically inhibition of mutant IDH1 by AGI-5198 induces expression of differentiation-associated zinc finger and BTB domain-containing protein 16 (ZBTB16 also termed PLZF) decreasing histone H3 lysine 9 trimethylation (H3K9me3) and promoting glioma cell differentiation In experimental glioma models AGI-5198 reduces tumor cell proliferation underscoring its utility for investigating differentiation therapy strategies targeting IDH1-mutant cancers

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