RAPID Slit Seal is a unique self-closing 96-well plate seal to minimize solvent evaporation and prevent needle clogging compared with conventional silicon mats. The adhesive-free, pre-cut slits made of silicone and PET allows easy insertion and withdrawal of pipette tips and sampling needles without catching and dragging. Acrylic-based adhesive is not above wells to prevent sample leaching. Seal can be easily applied and removed. Suggested applications include automated pipetting and liquid handling, SPE, HPLC, LC/MS, cell culturing and ADME.