Protein Molecular Weight Markers
ABclonal Technology TAF1 Rabbit pAb
This gene encodes the largest subunit of TFIID, a basal transcription factor required for RNA polymerase II activity. TFIID binds to the core promoter to position the polymerase and assembles the transcription complex. It also serves as a channel for regulatory signals and interacts with activators and other regulators to influence transcription initiation. This subunit contains two protein kinase domains and has acetyltransferase activity, acting as a ubiquitin-activating/conjugating enzyme. Mutations in this gene cause Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing results in multiple transcript variants, some sharing exons with TAF1 and additional downstream DYT3 exons.
ABclonal Technology ALDH1L2 Rabbit pAb
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.
Meso Scale Discovery PhosphoThr231/Tau TTL20 Plate
The Meso Scale Discovery Phospho-Thr231/Total Tau Kit is a multiplex immunoassay kit that allows for the simultaneous measurement of phosphorylated Thr231 tau and total tau in biological samples such as CSF serum plasma cell lysates and brain homogenates The kit contains a 96-well plate coated with capture antibodies specific for phosphorylated Thr231 tau and total tau It utilizes MSD s electrochemiluminescence detection technology to provide sensitive and accurate quantification of both analytes from a single small sample volume The kit includes all necessary reagents and can process up to 80 samples in duplicate It is suitable for studying Alzheimer s disease and other tauopathies
ABclonal Technology TCEA1 Rabbit pAb
Predicted to enable DNA binding activity, translation elongation factor activity, and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within erythrocyte differentiation and positive regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex.
ABclonal Technology Sterol carrier protein 2 Rabbit mAb
This gene encodes two proteins sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
ABclonal Technology PCDH1 Rabbit pAb
This gene belongs to the protocadherin subfamily within the cadherin superfamily. The encoded protein is a membrane protein found at cell-cell boundaries. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. The protein includes an extracelllular region, containing 7 cadherin-like domains, a transmembrane region and a C-terminal cytoplasmic region. Cells expressing the protein showed cell aggregation activity. Alternative splicing occurs in this gene.
ABclonal Technology Bmi1 Rabbit pAb
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
ABclonal Technology DDX43 Rabbit pAb
The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression.
ABclonal Technology NDUFAB1 Rabbit pAb
Predicted to enable acyl binding activity, acyl carrier activity, and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit.
ABclonal Technology CTNNA2 Rabbit pAb
Enables actin filament binding activity. Involved in negative regulation of Arp2/3 complex-mediated actin nucleation, regulation of neuron migration, and regulation of neuron projection development. Located in cytoplasm. Implicated in complex cortical dysplasia with other brain malformations.
ABclonal Technology TMC5 Rabbit pAb
Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Located in extracellular exosome.
ABclonal Technology COQ9 Rabbit pAb
This locus represents a mitochondrial ubiquinone biosynthesis gene. The encoded protein is likely necessary for biosynthesis of coenzyme Q10, as mutations at this locus have been associated with autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency.
ABclonal Technology APH1A Rabbit pAb
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimers disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
ABclonal Technology GAS7 Rabbit pAb
Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described.
ABclonal Technology DDAH1 Rabbit pAb
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity.