Protein Molecular Weight Markers
Shimadzu Scientific Instruments 20 UL MIRC MIXER WITH RECO DEV
NC3442163 20 UL MIRC MIXER WITH RECO DEV
ABclonal Technology CRYAB Rabbit mAb
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins consist of two gene products, alpha-A and alpha-B, which are part of the small heat shock protein (HSP20) family. Induced by heat shock, they act as molecular chaperones by holding proteins in large soluble aggregates, rather than renaturing and releasing them like true chaperones. These aggregates consist of 30-40 subunits with a 3:1 ratio of alpha-A to alpha-B. Alpha crystallins also have autokinase activity and contribute to intracellular architecture. Alpha-A is mainly expressed in the lens, while alpha-B is widely expressed in many tissues. Elevated alpha-B expression is linked to neurological diseases, and a missense mutation is associated with desmin-related myopathy. Alternative splicing produces multiple isoforms.
ABclonal Technology ETHE1 Rabbit pAb
This gene encodes a member of the metallo beta-lactamase family of iron-containing proteins involved in the mitochondrial sulfide oxidation pathway. The encoded protein catalyzes the oxidation of a persulfide substrate to sulfite. Certain mutations in this gene cause ethylmalonic encephalopathy, an infantile metabolic disorder affecting the brain, gastrointestinal tract and peripheral vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.
ABclonal Technology Bmi1 Rabbit pAb
This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.
ABclonal Technology JAKMIP2 Rabbit pAb
The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in multiple transcript variants.
ABclonal Technology SHP1 Rabbit pAb
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
ABclonal Technology MEKK3 Rabbit pAb
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively, it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
ABclonal Technology EDC4 Rabbit pAb
Predicted to be involved in deadenylation-independent decapping of nuclear-transcribed mRNA. Located in P-body and nucleoplasm.
ABclonal Technology GFPT2 Rabbit pAb
Predicted to enable glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process, fructose 6-phosphate metabolic process, and protein N-linked glycosylation. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytosol. Implicated in type 2 diabetes mellitus.