Protein Molecular Weight Markers
ABclonal Technology MED20 Rabbit pAb
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified.
ABclonal Technology RMND5A Rabbit pAb
Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex.
ABclonal Technology EFNB1 Rabbit pAb
The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.
![ABclonal Technology [KO Validated] NCOA2 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000135300.jpg-250.jpg)
ABclonal Technology [KO Validated] NCOA2 Rabbit pAb
The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.
ABclonal Technology LSM12 Rabbit pAb
Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein (PubMed34362892). Confers NAADP sensitivity to the two pore channel complex (TPCs) by acting as TPC accessory protein necessary for NAADP-evoked Ca(2+) release (PubMed34362892). ( LSM12_HUMAN,Q3MHD2 )
ABclonal Technology TCTA Rabbit pAb
Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be integral component of membrane.
ABclonal Technology GALK1 Rabbit pAb
Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population.
ABclonal Technology SNW1 Rabbit pAb
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants.
ABclonal Technology Ran Rabbit pAb
RAN (ras-related nuclear protein) is a small GTP-binding protein in the RAS superfamily, essential for RNA and protein translocation through the nuclear pore complex. It also regulates DNA synthesis and cell cycle progression. RANs nuclear localization requires regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Besides its role in nuclear-cytosol exchange, RAN also influences microtubule network formation and organization, particularly during mitosis. RCC1 generates a high concentration of RAN-GTP near chromatin, promoting microtubule nucleation. RAN is an androgen receptor (AR) coactivator and interacts differently with polyglutamine in AR. Expansion of polyglutamine repeats in AR is linked to Kennedys disease (spinal and bulbar muscular atrophy), where weak coactivation may lead to partial androgen insensitivity.
ABclonal Technology ATP6V1G3 Rabbit pAb
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits a, c, c, c and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three G subunit proteins. Transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology DLL1 Rabbit pAb
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
ABclonal Technology ZNF131 Rabbit pAb
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in intermediate filament cytoskeleton and nucleoplasm.
ABclonal Technology NSF Rabbit pAb
Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in intracellular protein transport, positive regulation of protein catabolic process, and positive regulation of receptor recycling. Located in Golgi apparatus, cytosol, and plasma membrane. Implicated in developmental and epileptic encephalopathy.
ABclonal Technology NAB1 Rabbit pAb
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within endochondral ossification, nervous system development, and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus.
ABclonal Technology BCMO1 Rabbit pAb
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules.