Protein Molecular Weight Markers
ABclonal Technology SCD1 Rabbit pAb
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. The protein belongs to the fatty acid desaturase family and is an integral membrane protein located in the endoplasmic reticulum. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17.
ABclonal Technology Phospho-IGF-IReceptorβ(Tyr1135/1136)/InsulinReceptorβ(Tyr1150/1151) Rabbit pAb
This gene encodes a member of the receptor tyrosine kinase family. The preproprotein is processed into alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands activates the insulin signaling pathway, regulating glucose uptake, release, and the synthesis and storage of carbohydrates, lipids, and proteins. Mutations in this gene cause inherited severe insulin resistance syndromes, such as type A insulin resistance syndrome, Donohue syndrome, and Rabson-Mendenhall syndrome. The receptor also binds insulin-like growth factor and has tyrosine kinase activity. It plays a critical role in transformation events and is overexpressed in malignant tissues, acting as an anti-apoptotic agent. Alternative splicing produces multiple transcript variants encoding distinct isoforms.
ABclonal Technology CTBP2 Rabbit pAb
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3 untranslated region was used to map this gene to chromosome 21q21.3, however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene.
ABclonal Technology DGKZ Rabbit pAb
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified.
ABclonal Technology GPR32 Rabbit pAb
This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. The encoded protein binds to resolvin D1 and lipoxin A4 and has been linked to pulmonary inflammation. A related pseudogene has been identified on chromosome 19.
ABclonal Technology GGPS1 Rabbit pAb
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
ABclonal Technology LSAMP Rabbit pAb
This gene encodes a member of the immunoglobulin LAMP, OBCAM and neurotrimin (IgLON) family of proteins. The encoded preproprotein is proteolytically processed to generate a neuronal surface glycoprotein. This protein may act as a selective homophilic adhesion molecule during axon guidance and neuronal growth in the developing limbic system. The encoded protein may also function as a tumor suppressor and may play a role in neuropsychiatric disorders. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
ABclonal Technology MED7 Rabbit pAb
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene.
ABclonal Technology OR1A1 Rabbit pAb
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.
ABclonal Technology β-TrCP/BTRC Rabbit pAb
This gene encodes an F-box protein, part of the F-box protein family, characterized by a 40 amino acid F-box motif. F-box proteins are subunits of the SCF (SKP1-cullin-F-box) complex, involved in phosphorylation-dependent ubiquitination. The F-box proteins are classified into three classes: Fbws, Fbls, and Fbxs. The protein encoded by this gene belongs to the Fbws class, containing both an F-box and multiple WD-40 repeats. It mediates CD4 degradation through interaction with HIV-1 Vpu and ubiquitinates phosphorylated NFKBIA, targeting it for degradation and activating nuclear factor kappa-B. Alternative splicing results in multiple transcript variants, and a related pseudogene exists on chromosome 6.
ABclonal Technology LLPH Rabbit pAb
Enables RNA binding activity. Predicted to be involved in dendrite extension and positive regulation of dendritic spine development. Located in chromosome and nucleolus.
ABclonal Technology SLC17A6 Rabbit pAb
Predicted to enable L-glutamate transmembrane transporter activity and neurotransmitter transmembrane transporter activity. Involved in neurotransmitter loading into synaptic vesicle. Predicted to be located in synaptic vesicle. Predicted to be active in excitatory synapse. Predicted to be integral component of synaptic vesicle membrane.
ABclonal Technology COL5A1 Rabbit pAb
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants.
ABclonal Technology AscL1 Rabbit pAb
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
ABclonal Technology ATRNL1 Rabbit pAb
Predicted to enable carbohydrate binding activity. Predicted to be involved in several processes, including animal organ morphogenesis, cell migration, and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in basement membrane.