Protein Molecular Weight Markers
ABclonal Technology Epn2 Rabbit pAb
Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within Notch signaling pathway, embryonic organ development, and in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin coat of endocytic vesicle. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN2 (epsin 2).
ABclonal Technology ORMDL3 Rabbit pAb
Involved in ceramide metabolic process. Acts upstream of or within several processes, including negative regulation of B cell apoptotic process, negative regulation of ceramide biosynthetic process, and positive regulation of protein localization to nucleus. Located in endoplasmic reticulum. Part of SPOTS complex.
ABclonal Technology ESRP1 Rabbit pAb
ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).
ABclonal Technology COPG2 Rabbit pAb
Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Part of COPI vesicle coat.
ABclonal Technology AKR1A1 Rabbit pAb
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
ABclonal Technology DFFB Rabbit pAb
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.
ABclonal Technology ESYT1 Rabbit pAb
Enables identical protein binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Located in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane.
ABclonal Technology PEX2 Rabbit pAb
This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein.
Cell Signaling Technology Blue Prestained Protein Marker, Broad Range (11-250 kDa) 25 ul
Blue Prestained Protein Marker, Broad Range (11-250 kDa) 25 ul
ABclonal Technology SULT1A1 Rabbit pAb
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene.
ABclonal Technology NOS1 Rabbit pAb
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.
ABclonal Technology RASAL2 Rabbit pAb
This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
ABclonal Technology LDHAL6B Rabbit pAb
Predicted to enable L-lactate dehydrogenase activity. Predicted to be involved in pyruvate metabolic process. Located in nucleus.
ABclonal Technology PSMC1 Rabbit pAb
The 26S proteasome is a multicatalytic proteinase complex consisting of a 20S core and a 19S regulator. The 20S core has 4 rings of 28 subunits, while the 19S regulator contains ATPase and non-ATPase subunits. Proteasomes cleave peptides in an ATP/ubiquitin-dependent process, important for class I MHC peptide processing. This gene encodes an ATPase subunit of the triple-A ATPase family with chaperone-like activity. It interacts with the hepatitis B virus X protein, critical for viral replication, and the adenovirus E1A protein, modifying proteasome activity. The subunit also interacts with ataxin-7, indicating a role in spinocerebellar ataxia type 7, a neurodegenerative disorder.
ABclonal Technology TP53I13 Rabbit pAb
Involved in several processes, including negative regulation of cell cycle, response to UV, and response to xenobiotic stimulus. Located in cytoplasm.