Protein Molecular Weight Markers
ABclonal Technology CDY1B Rabbit pAb
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region, this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.
ABclonal Technology TIAM1 Rabbit pAb
This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF), which promotes the exchange of GDP for GTP on RAC1, activating it to bind downstream effectors. This activation regulates RAC1 signaling pathways involved in cell shape, migration, adhesion, growth, survival, polarity, cytoskeletal dynamics, endocytosis, and membrane trafficking, playing key roles in invasion, metastasis, and cancer. The encoded protein also activates other Rho-like GTPases including CDC42, RAC2, RAC3, and RHOA. Multiple isoforms exist, differing in domain composition. All have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains, while only longer isoforms have an N-terminal myristoylation site, additional PH and ras-binding domains, and a PDZ domain. These isoforms interact with various proteins and lipids, undergoing complex regulation.
Sigma Aldrich Fine Chemicals Biosciences VivaspinR 500 5 kDa MWCO P
Designed for fast nondenaturing concentration of biological samples by membrane ultrafiltration. Up to 30-fold concentration of the sample can be achieved with recovery of the target molecule typically exceeding 95%.Vivaspin(R) sample concentrators are designed for fast nondenaturing concentration of biological samples by membrane ultrafiltration. Up to 30-fold concentration of the sample can be achieved with recovery of the target molecule typically exceeding 95%. The entire process is performed in a single tube with an upper compartment containing sample and lower compartment separated by a semipermeable membrane with a molecular weight cut-off (MWCO) selected by the user. Centrifugation is applied to force solvent through the membrane leaving a more concentrated sample in the upper chamber.Vivaspin(R) sample concentrators cater for sample volumes from 100 mul to 20 ml with a range of molecular weight cutoff values from Mr 3 000 to 100 000. for maximum recovery select a MWCO at
ABclonal Technology NSA2 Rabbit pAb
This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified.
Biotium Primary Antibody Mouse IgG1 Fc N2504.M1FC CF583R 1/EA
Anti-Mouse IgG1 (Fc) rVHH (N2504 M1FC) is a recombinant Alpaca VHH antibody that recognizes the Fc fragment of mouse IgG1 and is validated for IF flow and WB Red fluorescent STORM-compatible CF583R dye has Ex/Em at 583/606 nm Unit size 500 uL at 0 1 mg/mL
ABclonal Technology CYFIP1 Rabbit pAb
This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization. This protein also interacts with the synaptic functional regulator FMR1 protein and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion.
Medchemexpress LLC HY-W016009 100mg Medchemexpress, 2'-Deoxyadenosine-5'-monophosphate CAS:653-63-4 Purity:>98%
Medchemexpress, HY-K1011 250 μL 3 Color Prestained Protein Marker (10-190 kDa) CAS: Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
ABclonal Technology CDK5RAP2 Rabbit pAb
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimers disease. Alternative splicing results in multiple transcript variants.
ABclonal Technology ESRP1 Rabbit pAb
ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).
ABclonal Technology DDX51 Rabbit pAb
Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane.
ABclonal Technology OXT Rabbit pAb
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
ABclonal Technology CNTN4 Rabbit pAb
This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants.
ABclonal Technology POMGNT2 Rabbit pAb
This gene encodes a protein with glycosyltransferase activity although its function is not currently known.
ABclonal Technology RFC1 Rabbit pAb
This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3 end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.