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ARS-1323 is the racemic mixture containing ARS-1620 and a potent inhibitor of mutant KRAS G12C It can be used in research for biochemical binding screens as companion imaging drugs (CID) for KRAS G12C
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This compound is a novel inhibitor of mutant K-ras G12C, derived from patent WO 2015054572 A1. It is intended for research use only and not for patient administration.
Inhibitor of mutant K-ras G12C.
Utilizes allele-specific covalent targeting of Cys-12.
Targets an inducible allosteric switch II pocket.
Requires active cycling between active-GTP and inactive-GDP conformations for targeting.
Demonstrates feasibility for inhibiting mutant KRAS in laboratory settings.
High purity (98.10%).
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Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM) a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellspurity: 98%
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ARS-1630 is a novel inhibitor of mutant K-ras G12C, as described in patent WO 2015054572 A1. It is intended for research use only and is the less active enantiomer of ARS-1620.
Inhibits mutant K-ras G12C.
Less active enantiomer of ARS-1620.
Intended for research use only.
Purity of 98.1%.
Provided as a 10 mM solution in 1 mL DMSO.
Stable for 2 years at -80°C or 1 year at -20°C in solvent; aliquot to prevent freeze-thaw inactivation.
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