Complex Aldehydes
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Medchemexpress LLC 15-Deoxy-Δ-12,14-prostaglandin J2 | 87893-55-8 | ≥99.0% | 316.43 | 10 MG
15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2, primarily for research use. It acts as a selective PPARγ and a covalent PPARδ agonist, and promotes differentiation of C3H10T1/2 fibroblasts to adipocytes. This compound features an electrophilic, α, β-unsaturated ketone (an enone) in its cyclopentenone ring and has documented functions in inflammation, cell proliferation, survival, and apoptosis.
- Functions in inflammation, cell proliferation, survival, and apoptosis.
- Activates PPARδ by forming a covalent adduct.
- Suppresses LPS/IFN-gamma-stimulated NO production in mouse RAW264.7 cells.
