The Diatome trimming blades provides quick, easy, and accurate trimming at both room and cryo-temperatures. Due to the extreme sharpness of our diamond blades, less mechanical damage is applied to the sample during trimming. Very shiny sample faces and precise sides are the result. Room temperature applications include epoxy or acrylate resin embedded biological samples, metals, polymers, nanoparticles in polymers, and non-embedded brittle samples. Cryo-temperature applications include sucrose infiltrated and frozen hydrated bilogoical samples and soft polymers.