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Filtered Search Results
Medchemexpress LLC N-(3-(1H-pyrazol-5-yl)phenyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide | 00-00-0 | 98.0% | C16H11F3N4O2 | 10MG
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NRX-1532 is a small-molecule research compound that enhances the interaction between β-catenin and β-TrCP and is used to probe Wnt/β-catenin signaling in cellular and biochemical studies.
- Enhances β-catenin:β-TrCP interaction for signaling studies.
- High purity (98.0%) suitable for research applications.
- Soluble in DMSO at 250 mg/mL for in vitro use.
- Solid form, stable when stored as powder at -20°C.
- In solvent, stable up to 6 months at -80°C and 1 month at -20°C.
- Offered in multiple small-scale solid and solution pack formats for convenience.
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Medchemexpress LLC Medicagenic acid (Castanogenin) | 599-07-5 | MFCD02752364 | 5 MG
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Medicagenic acid (Castanogenin) is isolated from the roots of *Herniaria glabra*. It exhibits potent fungistatic effects against several plant pathogens and human dermatophytes. It also shows low enzyme inhibitory activities, targeting enzymes such as xanthine oxidase, collagenase, elastase, tyrosinase, and ChE.
- Isolated from the roots of *Herniaria glabra*.
- Exhibits potent fungistatic effects against several plant pathogens and human dermatophytes.
- Shows low enzyme inhibitory activities.
- Targets enzymes including xanthine oxidase, collagenase, elastase, tyrosinase, and ChE.
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Medchemexpress LLC Molidustat 50Mg | HY-12654-50MG
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Molidustat 50Mg
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eMolecules 653592-04-2 | Medchem Express | MT-DADMe-ImmA | 5mg | 446256941 | HY-101496 | MFCD30738019 | 293.39 | C13H19N5OS
Medchem Express | MT-DADMe-ImmA | 5mg | 446256941 | HY-101496 | 653592-04-2 | MFCD30738019 | 293.390 | C13H19N5OS
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Medchemexpress LLC 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | 327036-89-5 | MFCD04973552 | 99.8% | 222.26 g·mol⁻¹ | C10H10N2O2S | 5 MG
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TDZD-8 is a small-molecule, non-ATP-competitive inhibitor of glycogen synthase kinase-3β (GSK-3β) used in biochemical and cellular research to probe GSK-3β-regulated signaling pathways. It inhibits GSK-3β with an IC50 of approximately 2 μM and displays substantially weaker activity against several other kinases.
- Selective inhibition of GSK-3β (IC50 ≈ 2 μM).
- Reduced off-target activity against Cdk-1/cyclin B, CK-II, PKA, and PKC.
- High purity suitable for biochemical and cellular assays.
- Available in small-mass quantities and solution formats for assay convenience.
- Molecular formula C10H10N2O2S; molar mass 222.26 g·mol⁻¹.
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Medchemexpress LLC VU0155041 | 1093757-42-6 | 99.10% | C14H15Cl2NO3 | 100 MG
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VU0155041 is a potent and selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM for human mGluR4 and 693 nM for rat mGluR4. It has potential for the research of Parkinson's disease (PD).
- Potent, selective positive allosteric modulator (PAM) of mGluR4
- EC50s of 798 nM (human mGluR4) and 693 nM (rat mGluR4)
- Does not affect NMDA receptor currents in striatal medium spiny neurons
- Reverses catalepsy induced by Haloperidol in rats
- Reverses Reserpine-induced akinesia in rats
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Medchemexpress LLC Carboxyamidotriazole Orotate | 187739-60-2 | 99.7% | 580.76 | 5 MG
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Carboxyamidotriazole Orotate is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. It functions as a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. This product demonstrates anti-tumor, anti-inflammatory, and antiangiogenic effects.
- Functions as a cytostatic inhibitor of nonvoltage-operated calcium channels.
- Inhibits calcium channel-mediated signaling pathways.
- Exhibits anti-tumor effects.
- Exhibits anti-inflammatory effects.
- Exhibits antiangiogenic effects.
- Inhibits cell proliferation of LAMA84R and K562R cell lines.
- Reduces phosphorylation of CrkL.
- Shows dose-dependent inhibition of total and phosphorylated Bcr-Abl levels.
- Displays antitumor activity on CML xenografts.
- Increased survival in animal models.
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Medchemexpress LLC HY-B0281A 100mg Medchemexpress, Ranitidine (hydrochloride) CAS:66357-59-3 Purity:>98%
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Medchemexpress, HY-B0281A 100mg Ranitidine (hydrochloride) CAS:66357-59-3 Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Saroglitazar magnesium | 1639792-20-3 | 98.0% | 901.42 | 1 MG
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Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity, having EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. It is for research use only.
- Pparα agonist (ec50: 0.65 pm in hepg2 cells)
- Moderate pparγ activity (ec50: 3 nm in hepg2 cells)
- Causes dose-dependent reductions in serum triglycerides, free fatty acids, and glucose in db/db mice.
- Shown efficacy in lowering triglycerides in wistar rats and marmosets.
- Appears to have good potential as a therapeutic agent for dyslipidemia and diabetes.
- Appearance: solid
- Color: off-white to light yellow
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Medchemexpress LLC Duocarmycin DM free base | 1116745-06-2 | MFCD32201125 | 99.7% | 463.96 | C26H26ClN3O3 | 10 MG
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Duocarmycin DM free base is a DNA minor-groove alkylating cytotoxin used in antibody-drug conjugate (ADC) research and studies of DNA damage and cell-cycle effects. It alkylates adenine in AT-rich sequences and exhibits extremely potent cytotoxicity against cancer cells.
- dna minor-groove alkylator used as an adc cytotoxin and research payload.
- cas number 1116745-06-2; molecular formula C26H26ClN3O3; molecular weight 463.96.
- high solubility in DMSO (50 mg/mL); in vivo formulations achieve ≥2 mg/mL as clear solutions.
- storage: -20°C protected from light and under nitrogen; in solvent: -80°C up to 6 months, -20°C up to 1 month.
- available pack sizes include 1 mg, 5 mg, and 10 mg for stock preparation.
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Medchemexpress LLC HY-17427 500mg , Emtricitabine BW1592 CAS:143491-57-0 Purity:98%
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Medchemexpress, HY-17427 500mg Emtricitabine BW1592 CAS:143491-57-0 Formula:C8H10FN3O3S EC50: 0.01 µM (NRTI, PBMC), 0.026 µM (NRTI, HeLa cell) Purity:98% Emtricitabine is an inhibitor of the nucleoside reverse transcriptase ( NRTI ) and human immunodeficiency virus type 1 ( HIV-1 ); inhibits NRTI with an EC 50 of 0.01 µM in PBMC cell. Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-112171 500mg Medchemexpress, γ-L-Glutamyl-L-alanine CAS:5875-41-2 Purity:>98%
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Medchemexpress, HY-112171 500mg γ-L-Glutamyl-L-alanine CAS:5875-41-2 γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Dalcetrapib | 211513-37-0 | MFCD06407886 | 99.2% | 389.59 | 50 MG
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Dalcetrapib is an orally active cholesteryl ester transfer protein (CETP) inhibitor. It has shown activity against recombinant human CETP and human plasma CETP, playing a role in cholesterol metabolism research.
- Inhibits cholesteryl ester transfer protein activity
- Increases pre-β-HDL formation
- Increases plasma HDL cholesterol
- Promotes fecal elimination of neutral sterols and bile acids
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MEDCHEMEXPRESS LLC DSM265 5MG
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501871675 DSM265 5MG
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Medchemexpress LLC (E)-3-(4-chlorobenzyl)-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one | 2101739-18-6 | 99.9% | 10 MG
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RAD51-IN-1 is a small-molecule inhibitor of the RAD51 recombinase, described as a derivative of B02 and used in preclinical cancer research to study homologous recombination and DNA repair pathways.
- Potent RAD51 inhibitor for studying DNA repair
- Molecular formula C22H16ClN3O and molecular weight 373.83
- High purity suitable for biochemical assays (listed as 99.89%)
- Available in multiple package sizes, including 10 MG
- Yellow to orange solid, commonly supplied as a research reagent
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