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Filtered Search Results
Medchemexpress LLC Loratadine-d5 | 1398065-63-8 | 99.96% | 387.91 | 1 MG
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Loratadine-d5 is a deuterium labeled variant of Loratadine, a selective inverse peripheral histamine H1-receptor agonist. This compound shows anti-dengue-virus (DENV) activity and can inhibit the immunologic release of inflammatory mediators, with an IC50 of >32 μM. It is intended for research use only, serving as a valuable tool in drug development and quantitative analysis due to its stable heavy isotope labeling.
- Can be used as a tracer in research studies.
- Serves as an internal standard for quantitative analysis by techniques such as NMR, GC-MS, or LC-MS.
- Exhibits anti-dengue-virus (DENV) activity.
- Inhibits the immunologic release of inflammatory mediators.
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs.
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Research Products International Corp Miconazole Nitrate, 25 Grams
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Miconazole Nitrate is an antifungal medication. It belongs to the class of azole antifungal agents and is used to combat various fungal infections. It works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes. Without sufficient ergosterol, the integrity of the fungal cell membrane is compromised, leading to cell death.
In research and laboratory settings, miconazole nitrate may be used as a tool to study fungal biology and the mechanisms of antifungal action. Researchers may explore its efficacy against specific fungal strains and its impact on fungal cell structures and functions.
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Medchemexpress LLC HY-15287 5mg Medchemexpress, Nelfinavir CAS:159989-64-7 Purity:>98%
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Medchemexpress, HY-15287 5mg Nelfinavir CAS:159989-64-7 Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor ( K i =2 nM) and antiviral agent for the treatment of HIV infection. Nelfinavir is a broad-spectrum, anticancer agent [1] [2] [3] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-B0180A 200mg Medchemexpress, Imiquimod (hydrochloride) CAS:99011-78-6 Purity:>98%
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Medchemexpress, HY-B0180A 200mg Imiquimod (hydrochloride) CAS:99011-78-6 Imiquimod hydrochloride (R 837 hydrochloride) is a selective toll like receptor 7 (TLR7) agonist acting as an immune response modifier. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID 19. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Potassium oxonate | 2207-75-2 | 99.9% | 195.17 | 500 MG
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Potassium oxonate (Potassium azaorotate) is a uricase inhibitor primarily used in research to inhibit the phosphorylation of 5-FU and for creating hyperuricemia animal models. This selective competitive inhibitor blocks hepatic uricase and is metabolized in the gastrointestinal tract, distributing primarily in small intestine cells where it is converted to cyanuric acid.
- Inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.
- Utilized in animal modeling to create hyperuricemia models.
- Functions as a selective competitive uricase inhibitor.
- Blocks the action of hepatic uricase.
- After metabolism, primarily distributes within the cells of the small intestine.
- Converted to cyanuric acid in the gastrointestinal tract through two pathways.
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eMolecules 30544-47-9 | Medchem Express | Etofenamate | 100mg | 446268239 | HY-17361 | MFCD00242806 | 369.34 | C18H18F3NO4
Ambeed | 2-(Methylamino)benzamide | 250mg | 592282782 | A323524 | 7505-81-9 | MFCD00025469 | 150.181 | C8H10N2O
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MOLTOX Molecular Toxicology Inc Mitomycin C, 5 ug/vial, 5 vials/pack, Store in Refrigerator
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For use in Ames test with TA102 tester strain. Dose 0.5 µg/plate. Reconstitute with organic solvents such as DMSO or sterile dH2O as applicable. Direct acting mutagens do not require the use of S9 metabolic activation to cause mutagenicity. CONTROLCHEM™ chemicals are obtained from major suppliers of research chemicals and are employed without further characterization or purification. Packaged quantities are precise within 1%. Please Note: CONTROLCHEM™ chemicals are known mutagens/carcinogens/toxins and are sold only to those experienced in the safe handling and disposal of hazardous materials. Consult your Institutional Safety Officer before ordering.
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Research Products International Corp Chlortetracycline Hydrochloride, 5 Grams
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Chlortetracycline Hydrochloride is a tetracycline antibiotic. Chlortetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. The interference disrupts the translation process and inhibits bacterial growth.
This antibiotic offers a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative bacteria. It also forms complexes with calcium, magnesium, aluminum, and iron, leading to reduced absorption.
Additionally, it is useful to study bacterial susceptibility patterns or as a selective agent in culture media to isolate bacteria that are sensitive to this antibiotic.
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Medchemexpress LLC Didesmethyl cariprazine | 839712-25-3 | MFCD34469127 | 99.6% | 399.36 | C19H28Cl2N4O | 5 MG
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Didesmethyl cariprazine is the predominant circulating, orally active metabolite of cariprazine used in pharmacology research to probe dopaminergic and serotonergic mechanisms. It crosses the blood-brain barrier and modulates dopamine and serotonin receptors, making it useful for receptor profiling, metabolism studies, and in vivo pharmacokinetic investigations.
- Orally active, blood-brain barrier permeable compound.
- Partial agonist at D2 and D3 receptors.
- Full agonist at 5-HT1A and antagonist at 5-HT2B.
- Suitable for in vitro receptor pharmacology studies.
- Applicable to in vivo pharmacokinetic and metabolism research.
- Provided as a solid with high reported purity for research use.
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eMolecules 53123-88-9 | Sirolimus | Advanced ChemBlocks - In Stock914.187 | C51H79NO13 | 98.000 | CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O | 1g...
Sirolimus | Advanced ChemBlocks - In Stock | 53123-88-9914.187 | C51H79NO13 | 98.000 | CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O | 1g | 381426230
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Medchemexpress LLC LEQ506 | 1204975-42-7 | 98.9% | 432.56 | 100 MG
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LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50 values of 2 nM in human and 4 nM in mouse. It inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) by decreasing Gli mRNA, with an IC50 approximately 6-fold lower than that of Compound 2. At 1%, LEQ506 achieves 80% to 90% inhibition for Gli1 and 60% to 70% for Ptch1.
- Inhibits smoothened (Smo)
- Has IC50 values of 2 nM in human and 4 nM in mouse
- Inhibits Hedgehog (Hh) signaling
- Decreases Gli1 mRNA by 70% to 80%
- Preferentially inhibits Gli1 over Ptch1 mRNA
- Is an efficacious compound
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eMolecules 2320274-78-8 | Medchem Express | (RS)-Butyryltimolol | 5mg | 446257606 | HY-102032A | 386.51 | C17H30N4O4S
Ambeed | 4-Bromo-2-hydroxybenzamide | 250mg | 649783284 | A866671 | 5428-40-0 | MFCD07780674 | 216.034 | C7H6BrNO2
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Medchemexpress LLC Chloramphenicol succinate sodium | 982-57-0 | 1 ML
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Chloramphenicol succinate sodium is a prodrug of Chloramphenicol, acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. It also serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH). This compound has shown significant inhibitory effects on colitis and is used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis, and inflammatory bowel disease. It is slowly oxidized to Chloramphenicol by human bone marrow monocytes and mitochondria from liver and kidney.
- Molecular weight: 445.18
- Formula: C15H15Cl2N2NaO8
- Appearance: Solid, white to light yellow
- Purity: 97.17% (as per data sheet)
- Soluble in DMSO (125 mg/mL) and H2O (50 mg/mL)
- Alleviates DSS-induced colitis in mice
- Enhances gut barrier integrity via increased tight junction protein expression
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Medchemexpress LLC HY-B0177 100mg Medchemexpress, Tinidazole CAS:19387-91-8 Purity:>98%
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Medchemexpress, HY-B0177 100mg Tinidazole CAS:19387-91-8 Tinidazole, an orally available antibacterial agent, is a 5-nitroimidazole with selective activity against anaerobic bacteria and protozoa. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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eMolecules 773-76-2 | Medchem Express | Chloroxine | 100mg | 446272451 | HY-B0295 | MFCD00006786 | 214.05 | C9H5Cl2NO
Medchem Express | Chloroxine | 100mg | 446272451 | HY-B0295 | 773-76-2 | MFCD00006786 | 214.050 | C9H5Cl2NO
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