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The PathHunter CALCR-RAMP2 (AMY2) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. calcitonin) based activation of CALCR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CALCR and EA-tagged β-Arrestin-2. Activation of CALCR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
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Desulfovibrio vulgaris strain C-6 [CT1, IFO 13699, NCIB 8372] is a whole-genome sequenced strain. This anaerobic bacterium is cited to produce D(-)-lactate dehydrogenase and it has applications in bioresistance testing.
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Quantitative Genomic DNA from Streptococcus pyogenes strain Bruno can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
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Monoclonal antibody prepared against the Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor binding domain. This product was purified from clone 2TP1C3 hybridoma supernatant by protein G affinity chromatography.
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Genomic RNA isolated from Influenza A virus (H3N2) strain A/Virginia/ATCC6/2012 (ATCC VR-1811). This product was prepared using methods known to inactivate viruses. It can be used in PCR and other molecular biology applications.
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Enterococcus gallinarum strain NCDO 2707 [17R] was isolated from a chicken's duodenum. This whole-genome sequenced bacterial strain was typed as Lancefield’s group D and was confirmed by PCR to have the vanC-1 gene. The bacterium can be used in antimicrobial resistance research and drug development.
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Clostridium perfringens strain NCTC 8238 [281/50 is a bacterial anaerobe isolated from boiled salt beef. The cpa (Alpha toxin) and cpe (Enterotoxin) genes were confirmed to be present in this strain.
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