General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen LPA3 Lysophospholipid Receptor Stable Cell Line, 2 vials. (HTS130C)
The ChemiScreen LPA3 Lysophospholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. LPA) based activation of LPAR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR3, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CX3CR1 Chemokine Receptor Membrane Preparation, 1 vial. (HTS015M)
The ChemiScreen CX3CR1 Chemokine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CX3CR1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx PrecisION hGlyRA1 Recombinant Stable Cell Line, 2 vials. (CYL3056)
The PrecisION hGlyRA1 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying GlyRA1 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses GlyRA1 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Eurofins Discoverx PrecisION hnAChR α7/ric3 Recombinant Stable Cell Line, 2 vials. (CYL3097)
The PrecisION hnAChR α7/ric3 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying nAChR α7/ric3 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses nAChR α7/ric3 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Eurofins Discoverx ChemiScreen CXCR2 Chemokine Receptor Stable Cell Line, 2 vials. (HTS002C)
The ChemiScreen CXCR2 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen TRH Thyrotropin-Releasing Hormone Receptor Stable Cell Line, 2 vials. (HTS126C)
The ChemiScreen TRH Thyrotropin-Releasing Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. TRH) based activation of TRHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TRHR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of TRHR, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay Motilin Receptor Frozen Cells, 2 Vials of Cells. (HTS121RTA)
The Ready-to-Assay Motilin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. motilin) based activation of MLNR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MLNR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of MLNR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay SST3 Somatostatin Receptor Frozen Cells, 2 Vials of Cells. (HTS171RTA)
The Ready-to-Assay SST3 Somatostatin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. somatostatin) based activation of SSTR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR3 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay M5 Acetylcholine (Muscarinic) Receptor Frozen Cells, 2 Vials of Cells. (HTS075RTA)
The Ready-to-Assay M5 Acetylcholine (Muscarinic) Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. acetylcholine) based activation of CHRM5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CHRM5 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CHRM5, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Zen Bio Inc HUMAN CORNEAL EPI PROGENITOR
Life Sciences,Cell Culture & Stem Cell Biology,Corneal Epithelium Progenitors; Human
Zen Bio Inc Cryopreserved Human Hepatic Sinusoidal Endothelial Cells, (500,000 cells/vial)
Human Hepatic Non-Parenchymal CellsCryopreserved Human Hepatic Sinusoidal Endothelial Cells, (500,000 cells/vial) Cells have been tested for performance in viability. Cells have tested negative for HIV-1, HIV-2, HbsAG, HbcAB, HCV, and RPR. Cells are additionally tested for CMV.
Cell Biologics B129 MOUSE PRIMARY TRACHEAL AN
B129 MOUSE PRIMARY TRACHEAL AND BRONCHIAL EPITHELIAL CELLS Frozen Vial
