General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter EDG2 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0839C3)
The PathHunter EDG2 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of EDG2 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged EDG2. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting EDG2-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter Jurkat CD200R Signaling Cell Line, 2 vials. (93-1136C19)
The PathHunter CD200R Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. CD200) based activation of CD200R receptors via detection of SH2 domain protein recruitment. The included cell line overexpresses ProLink-tagged CD200R target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
Medchemexpress LLC CD47 protein, rat (HEK293, Fc) | 95.0% | 1 MG
Recombinant rat CD47 extracellular domain produced in HEK293 cells and presented as a C-terminal human Fc fusion protein. Intended for research use in in vitro binding studies, biochemical characterization, and assay development. Supplied purified and frozen to preserve structural integrity and activity.
- Recombinant rat CD47 extracellular domain.
- Expressed in HEK293 mammalian cells.
- C-terminal human Fc fusion tag for stability and detection.
- Purity approximately 95.0%.
- Supplied frozen; store at -20°C.
- Available in a 1 mg format.
Revvity Health Sciences Inc Tag-lite δ-Opioid Receptor (OP1) Frozen & Labeled Cells, 200 Assay Points
Tag-lite δ-Opioid Receptor (OP1) Frozen & Labeled Cells, 200 Assay Points
Eurofins Discoverx PathHunter CHO-K1 GPR141 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0385C2A)
The PathHunter GPR141 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR141 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR141 and EA-tagged β-Arrestin-2. Activation of GPR141 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Quantitative Synthetic; Dientamoeba fragilis DNA
Quantitative Synthetic DNA from Dientamoeba fragilis can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine protozoan load. Preparation includes fragments from the 18S ribosomal RNA, internal transcribed spacer 1 (ITS1), and 5.8S ribosomal RNA regions.
ATCC Actinomyces naeslundii; genomic DNA
Genomic DNA isolated from Actinomyces naeslundii Strain 279. This bacterial strain is also available as ATCC Catalog No. 12104™.
ATCC Cryptococcus gattii; A1MR272
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
Medchemexpress LLC GIP Human HEK293 10ug
The GIP protein is a member of the glucagon superfamily an important incretin hormone that stimulates pancreatic beta cells to secrete insulin in response to food intake Through its G protein-coupled receptor it activates adenylyl cyclase and other signal transduction pathways GIP Protein Human (HEK293 hFc) is the recombinant human-derived GIP protein expressed by HEK293 with C-hFc labeled tag
Biochain Institute Inc Paraffin Tissue Section - Progressive Supranuclear Palsy: Brain: Occipital Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Genscript Corporation RH7777/EDG4 Stable Cell Line
Lysophosphatidic acid (LPA) a bioactive lipid produced by several cell types including postmitotic neurons and activated platelets is thought to be involved in various biological processes including brain development Three cognate G-protein coupled receptors encoded by lpa(1)/lp(A1)/Edg-2/Gpcr26 lpa(2)/lp(A2)/Edg-4 and lpa(3)/lp(A3)/Edg-7 mediate the cellular effects of LPA However many LPA-induced responses including phospholipase C activation Ca sup 2 /sup mobilization adenylyl cyclase activation proliferation JNK activation AKT activation and stress fiber formation were absent or severely reduced in embryonic fibroblasts derived from lpa(1)(-/-) lpa(2)(-/-) mice The lysophosphatidic acid receptor LPA2 or endothelial differentiation G-protein coupled receptor 4(EDG-4) is expressed most abundantly in testes and peripheral blood leukocytes It is reported to be a distinctive functional marker for ovarian carcinoma
Genscript Corporation CHO-K1/BB3 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human bombesin receptor subtype 3 (BB3) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways