General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen P2Y11 Purinergic Receptor Stable Cell Line, 2 vials. (HTS213C)
The ChemiScreen P2Y11 Purinergic Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP) based activation of P2RY11 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses P2RY11 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of P2RY11, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PathHunter CHO-K1 LTB4R β-Arrestin Cell Line, 2 vials. (93-0292C2)
The PathHunter LTB4R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. leukotriene B4) based activation of LTB4R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged LTB4R and EA-tagged β-Arrestin-2. Activation of LTB4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx KILR MM-1R Cell Pool, 2 vials. (97-1045P052)
The KILR MM-1R cell pool is a stable, engineered target cell pool, which closely reflects the heterogeneous native protein expression of tumor environments, used to measure direct cell death mediated by immunooncology treatments (e.g. checkpoint modulators, bispecifics, CAR-T, etc.) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell pool is a heterogeneous population of MM-1R cells that overexpress a ProLabel-tagged housekeeping gene. Upon effector cells-mediated cell lysis, ProLabel is released to the media, where EA in the detection kit produces an EFC signal proportional to the level of ProLabel released. This allows for calculation of percent lysis of the KILR cell pool. This stable cell pool is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kilr.
Genscript Corporation CHO-K1/Lag3 Stable Cell Line
Lymphocyte-activation gene 3 also known as LAG-3 is a protein which in humans is encoded by the LAG3 gene [1] LAG3 which was discovered in 1990[2] and was designated CD223 (cluster of differentiation 223) after the Seventh Human Leucocyte Differentiation Antigen Workshop in 2000[3] LAG-3 is a cell surface molecule with diverse biologic effects on T cell function It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders
Medchemexpress LLC Mertk protein, human (HEK293, His) | >95.0% | 50UG
Recombinant human MERTK protein (HEK293, His) is a C-terminally 10xHis-tagged receptor tyrosine kinase produced in HEK293 cells and supplied as a lyophilized powder. The protein corresponds to residues A21-I505 (UniProt Q12866), is glycosylated, and is suitable for biochemical assays, binding studies, and signaling research.
- Format: Lyophilized powder.
- Size: 50 μg.
- Purity greater than 95% by reducing SDS-PAGE.
- Predicted mass 55.4 kDa; observed ~120 kDa (glycosylated).
- Storage buffer: PBS with 6% trehalose, pH 7.4.
- Reconstitution: do not reconstitute below 100 μg/mL in ddH2O; aliquot and store at -20°C or -80°C.
Biochain Institute Inc Matched Pair - Total Protein - Human Primary Tumor and Metastatic Tumor Tissue (PM): Kidney, 0.2 x2 mg /PK
BioChain's human total protein matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of total protein isolated from primary tumor and its adjacent normal tissue; PM consists of total protein from primary tumor andcorresponding metastastic tumor. Total proteins in each pair are prepared from the same donor. This product line is designedfor identifying tumor-specific genes and tumor metastasis genes.
ACROBiosystems HEK293/Human ASGR1&ASGR2 Stable Cell Line
ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2).
Eurofins Discoverx Ready-to-Assay CXCR4 Chemokine Receptor Frozen Cells, 2 Vials of Cells. (HTS004RTA)
The Ready-to-Assay CXCR4 Chemokine Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. CXCL12/SDF-1α) based activation of CXCR4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR4 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR4, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Amsbio LLC Human Kidney (renal cell) normal FFPE tissue block
Human Kidney (renal cell) normal FFPE tissue block
Discovery Life Sciences Breast Cancer Tx Naive PBMC
PBMCs Peripheral Blood Mononuclear Cells are immune cells isolated from whole blood and viably cryopreserved providing a foundational material for immunology studies cell therapy research and functional immune assays
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Brain: Pons, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Breast, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx ChemiScreen SST3 Somatostatin Receptor Stable Cell Line, 2 vials. (HTS171C)
The ChemiScreen SST3 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR3 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR3, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.