General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 AVPR1B β-Arrestin Cell Line, 2 vials. (93-0486C2)
The PathHunter AVPR1B cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. testosterone, norgestrel) based activation of AVPR1B GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AVPR1B and EA-tagged β-Arrestin-2. Activation of AVPR1B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 mGHSR1a β-Arrestin Cell Line, 2 vials. (93-0605C2)
The PathHunter mGHSR1a cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. grehlin) based activation of mGHSR1a GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mGHSR1a and EA-tagged β-Arrestin-2. Activation of mGHSR1a stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen SST1 Somatostatin Receptor Membrane Preparation, 1 vial. (HTS170M)
The ChemiScreen SST1 Somatostatin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of SSTR1 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx PathHunter CHO-K1 PTHR2 β-Arrestin Cell Line, 2 vials. (93-0306C2)
The PathHunter PTHR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PTH) based activation of PTHR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTHR2 and EA-tagged β-Arrestin-2. Activation of PTHR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ACROBiosystems Human CCR8 2Vials
This entry represents CC chemokine receptor 8 (CCR8) which it is expressed predominantly in lymphoid tissues and has also been found in glomerular podocytes and human umbilical vein endothelial cells (HUVECs). CCR8 is associated with Th2 lymphocytes which are critical for allergy and has a role in lymphocyte activation migration proliferation and differentiation and in allergic diseases. CCR8 binds to CCL1 (also known as I-309) and to CCL16 (also known as liver expressed chemokine). It also exhibits a high affinity for three chemokines of viral origin: vMIP-I vMIP-II and vMCC-I.
ATCC Toxoplasma gondii; ME49
Toxoplasma gondii strain me49 is in haplogroup 2. This parasitic protozoan is propagated in Hs27 cells (ATCC CRL-1634) and can be used in food and waterborne pathogen research and opportunistic pathogen research.
BPS Bioscience Inc CD40 - HEK293 Cell Line, 2 vials, Recombinant HEK293 cell line
Recombinant HEK293 cell line expressing full length human CD40 (Tumor necrosis factor receptor superfamily member 5; TNFRSF5), Genbank Accession No. NP_001241.1. Expression is confirmed by real-time qPCR and Western blot.Included with the purchase of these cells is a 10-year license to use the cells and their progeny in your immediate laboratory, for research use only.
ATCC Human adenovirus 6; Strain: Tonsil 99
Human adenovirus 6 strain Tonsil 99 is propagated in HeLa cells (ATCC CCL-2). This strain was isolated from the tonsil tissue of a 7-year-old girl with chronically infected and enlarged tonsils in Washington, DC. The strain has applications in respiratory disease research.
ATCC Hyphozyma roseonigra
Hyphozyma roseonigra strain 30-1-1B is provided as an ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant. This fungal type strain was isolated from soil in New Jersey and is known to produce diol and furan compounds.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Brain: Tuberculum Cinereum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Paraffin Tissue Section - Human Diabetic Diseased Tissue: Parathyroid, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Paraffin Tissue Section - Human Brain Tumor: Ependymal Glioma, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx ChemiScreen PTH1 Parathyroid Hormone Receptor Stable Cell Line, 2 vials. (HTS030C)
The ChemiScreen PTH1 Parathyroid Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. parathyroid hormone) based activation of PTH1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTH1R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PTH1R, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PathHunter U2OS HTR2C (VNV) β-Arrestin Cell Line, 2 vials. (93-0938C3)
The PathHunter HTR2C(VNV) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of HTR2C(VNV) GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HTR2C(VNV) and EA-tagged β-Arrestin-2. Activation of HTR2C(VNV) stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.