General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS ACVR1B/BMPR2 Dimerization Cell Line, 2 vials. (93-1072C3)
The PathHunter ACVR1B/BMPR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. activin A) induced dimerization of ACVR1B/BMPR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR1B target protein fused to PK alongside BMPR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1B/BMPR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Vector Biolabs human CDK9 shRNA Adenovirus (Ad-h-CDK9-shRNA)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
American Research Products Inc PrEST Antigen ADRB2
PrEST Antigen ADRB2 antigen APrEST86749 for adrenoceptor beta 2 surface Recombinant protein fragment of Human ADRB2
Lonza Walkersville P1 Prim Cell 96-well Nufe Kit
The P1 Primary Cell 96-well Nucleofector Kit is one of our five kits suited for medium-throughput transfection of primary cells when working with the 4D-Nucleofector 96-well Unit This kit has been determined to be optimal for transfecting following cell types ADSC undiff (human) MSC (human) Preadipocytes (human) PrEC (human) The respective cell type-specific Optimized Protocols or recommendations are available under Instructions or in our Lonza Bioscience knowledge database In these Optimized Protocols the best Nucleofection conditions are indicated In addition we share our experience and knowledge for treatment of individual cell types The kit is available in different variants for either 1 x 96 or 10 x 96 reactions
Montana Molecular Borealis Arrestin 5-HT2AR Assay - 10mL
Measure arrestin signaling kinetics in real time with the live cell, fluorescent Borealis arrestin - 5-HT2A receptor assay. Add the unmodified 5-HT2A receptor and Borealis sensor to cells and measure robust signals the next day on an automated plate reader or fluorescence imaging system. This assay is genetically encoded and packaged in BacMam for efficient transduction in most cell types - including uniform and near 100% efficiency in HEK293 cells as well as expression in many primary or iPSC-derived cells. The kit includes the arrestin sensor BacMam, 5HT2AR BacMam, GRK3 BacMam, 500mM sodium butyrate in H2O, and a positive control receptor and agonist (AT1R BacMam and 5mM Angiotensin II in H2O). Borealis kits for several other receptors are also available, and larger-sized kits are available on request. Other Montana Molecular tools including the DAG and Calcium sensors can be used alongside this assay.
Amsbio LLC MIP-2 Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
MIP-2 Leeporter™ Luciferase Reporter-RAW264.7 Cell Line
Genscript Corporation CHO-K1/ACE2 Stable Cell Line
Recombinant CHO-K1 cells stably express Angiotensin-converting enzyme 2 (ACE2) on the cell surface The surface expression of ACE2 is validated by FACS analysis This stable cell line product is designed for cell-based binding assays that measure binding affinity and stability of antibody based biologics binding with ACE2
Sigma Aldrich Fine Chemicals Biosciences Skeletal Muscle Cell Growt
Skeletal Muscle Cell Growth Medium Kit
Eurofins Discoverx PathHunter HEK 293 IL9R/IL2RG Dimerization Cell Line, 2 vials. (93-1036C1)
The PathHunter IL9R/IL2RG Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-9) induced dimerization of IL9R/IL2RG receptors. This product uses EFC technology. The cell line included overexpresses IL2RG target protein fused to PK alongside IL9R target protein fused to EA. Upon ligand-induced dimerization of IL9R/IL2RG, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
ATCC Pasteurella multocida; subsp. multocida
Pasteurella multocida subsp. multocida strain NCTC 10325 is a bacterium that was isolated from a bovine in the United States.
ATCC MDA-MB-231; Breast Adenocarcinoma; Genomic DNA, Human
High molecular weight genomic DNA isolated from the MDA-MB-231 human breast cancer cell line.
Eurofins Discoverx PathHunter U2OS TGFBR1A/ACVR2A Dimerization Cell Line, 2 vials. (93-1012C3)
The PathHunter TGFBR1A/ACVR2A Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GDF-11) induced dimerization of TGFBR1A/ACVR2A receptors. This product uses EFC technology. The cell line included overexpresses TGFBR1A target protein fused to PK alongside ACVR2A target protein fused to EA. Upon ligand-induced dimerization of TGFBR1A/ACVR2A, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Biochain Institute Inc Matched Pair - Paraffin Tissue Section - Human Primary Tumor and Normal (PP): Colon, 5 x2 slides /PK
BioChain's FFPE human paraffin tissue (FFPE) section matched pair products include: Primary Pair (PP), Primary and Metastatic Pair (PM). PP consists of paraffin tissue sections of primary tumor and its adjacent normal tissue; PM consists of paraffin tissue sections of primary tumor and corresponding metastatic tumor. Paraffin tissue sections in each pair are prepared from the same donor. This product line is ideal for localization of tumor- specific genes and tumor metastatic genes.
Eurofins Discoverx PathHunter TACR1 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0717C3)
The PathHunter TACR1 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of TACR1 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged TACR1. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting TACR1-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx Ready-to-Assay FFA3/GPR41 Free Fatty Acid Receptor Frozen Cells, 2 Vials of Cells. (HTS135RTA)
The Ready-to-Assay FFA3/GPR41 Free Fatty Acid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. free fatty acids) based activation of FFAR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR3 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.