General Cell Lines and Cell Cultures
Biochain Institute Inc Frozen Tissue Section - hypertension: Artery, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
ATCC Saccharolobus solfataricus; P2; genomic DNA
Genomic DNA isolated from Saccharolobus solfataricus strain DSM 1617 [P2] (ATCC 35092). This product can be used in PCR and other molecular biology applications.
Eurofins Discoverx PathHunter ADCYAP1R1 Total Internalization U2OS Cell Line, 2 vials. (93-0885C3)
The PathHunter ADCYAP1R1 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of ADCYAP1R1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged ADCYAP1R1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the ADCYAP1R1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx Ready-to-Assay SST2 Somatostatin Receptor Frozen Cells, 2 Vials of Cells. (HTS028RTA)
The Ready-to-Assay SST2 Somatostatin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Aspergillus clavatus; Kral; genomic DNA
Genomic DNA isolated from Aspergillus clavatus QM 1276. This fungal strain is also available as ATCC Catalog No.: 1007™.
Eurofins Discoverx PathHunter OPRM1 Total GPCR Internalization U2OS Cell Line, 2 vials. (93-0745C3)
The PathHunter OPRM1 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of OPRM1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged OPRM1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the OPRM1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 mGCGR β-Arrestin Cell Line, 2 vials. (93-0575C2)
The PathHunter mGCGR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. glucagon) based activation of mGCGR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mGCGR and EA-tagged β-Arrestin-2. Activation of mGCGR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC HCM-CSHL-0057-C18; Cancer Model Primary; Adenocarcinoma Sigmoid Colon; Human (Homo sapiens)
A patient-derived next-generation cancer model generated by the Human Cancer Models Initiative (HCMI). HCM-CSHL-0057-C18 (ATCC No. PDM-2) was isolated from primary adenocarcinoma of large intestine tissue. This tumor-derived model can be used in basic research and pharmacological screening applications. Data for the parental tumor and the tumor-derived organoid models are available at the GDC. Additional molecular characterizations may be available at the GDC. Additional controlled data may be available via dbGaP.
Innovative Research Inc Sngl Dnr Hmn Hd Nck Cncr Srm
Single Donor Human Head and Neck Cancer Serum - Single Donor Human Head and Neck Cancer Serum from Innovative Research is whole blood derived. Available volumes are variable, and range from 0.5ml to 1.0ml per vial (you can select your exact samples from our inventory, if desired). A detailed patient history and clinical information is recorded at the time of draw, and multiple samples and plasma/serum matched sets from the same donor are often available. Innovative Research has a wide network of collection centers, which allows us to collect from nearly any donor type. We are able to deliver to you a list of available samples that includes comprehensive donor data so that you can select the particular samples that best fit with your research requirements.
Eurofins Discoverx PathHunter U2OS KISS1R β-Arrestin Cell Line, 2 vials. (93-0927C3)
The PathHunter KISS1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. kisspeptin) based activation of KISS1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged KISS1R and EA-tagged β-Arrestin-2. Activation of KISS1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS IL17RD/TNFR2 Dimerization Cell Line, 2 vials. (93-1068C3)
The PathHunter IL17RD/TNFR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. TNFα) induced dimerization of IL17RD/TNFR2 receptors. This product uses EFC technology. The cell line included overexpresses IL17RD target protein fused to PK alongside TNFR2 target protein fused to EA. Upon ligand-induced dimerization of IL17RD/TNFR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
ATCC Blastocystis hominis; JDR
Blastocystis hominis strain JDR is a parasitic protozoan that was isolated from a human with diarrhea in Bethesda, Maryland. This product has applications in enteric disease research.