General Cell Lines and Cell Cultures
ATCC SK-LU-1; Lung Adenocarcinoma; Human (Homo sapiens)
SK-LU-1 are epithelial cells that were isolated from the lungs of a 60-year-old, White female patient with adenocarcinoma. This product has applications in cancer research.
ATCC Quantitative Genomic DNA from; Klebsiella pneumoniae; Strain: ART 2008133
Quantitative Genomic DNA from Klebsiella pneumoniae strain ART 2008133 can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
ATCC Enterobacter hormaechei subsp. steigerwaltii; Strain: SC10435
Enterobacter hormaechei subsp. steigerwaltii strain SC10435 was isolated in 1963 from human blood culture in Toronto, Canada. This strain is resistant to penicillins, cephalosporins, aztreonam, and pipercillin-tazobactam and it is sensitive to carbapenems. The depositor states that this strain produces a Class C, AmpC-type beta-lactamase (P99 cephalosporinase).
Eurofins Discoverx PrecisION hERG Recombinant Stable Cell Line, 2 vials. (HEK293) (CYL3039)
The PrecisION hERG Recombinant Stable Cell Line is a stable, engineered cell line for use in studying hERG ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses hERG ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Genscript Corporation CHO-K1/B7-H2 Stable Cell Line
Ligand for the T-cell-specific cell surface receptor ICOS acts as a costimulatory signal for T-cell proliferation and cytokine secretion It also induces B-cell proliferation and differentiation into plasma cells It could also play an important role in mediating local tissue responses to inflammatory conditions as well as modulating the secondary immune response by co-stimulating memory T-cell function
Eurofins Discoverx PathHunter LTB4R Total Internalization U2OS Cell Line, 2 vials. (93-0810C3)
The PathHunter LTB4R Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of LTB4R via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged LTB4R and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the LTB4R receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Human respiratory; syncytial virus; Strain: A2 Purified
Human respiratory syncytial virus, Purified strain A2 is propagated in HeLa cells (ATCC CCL-2). This strain was isolated in 1961 from the lower respiratory tract of an infant with bronchiolitis and bronchopneumonia in Melbourne, Australia. This product is provided as a purified preparation and has applications in respiratory disease research and assay development.
ATCC U-118 MG; Glioblastoma; Human (Homo sapiens)
U-118 MG is a cell line exhibiting mixed morphology that was isolated in 1966 from malignant gliomas from a 50-year-old, male with Grade IV glioblastoma.
Eurofins Discoverx PrecisION hnAChR α7/ric3 Recombinant Stable Cell Line, 2 vials. (CYL3097)
The PrecisION hnAChR α7/ric3 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying nAChR α7/ric3 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses nAChR α7/ric3 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Eurofins Discoverx PathHunter CHO-K1 mADORA3 β-Arrestin Cell Line, 2 vials. (93-0683C2)
The PathHunter mADORA3 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MECA) based activation of mADORA3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mADORA3 and EA-tagged β-Arrestin-2. Activation of mADORA3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Genscript Corporation CHO-K1/SST1/Gqi5 Stable Cell L
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner SST1 receptor is a Gi/Go-coupled GPCR which is expressed in pancreatic islets pituitary Cerebellum (Purkinje cells) frontal cortex (pyramidal cells) hippocampus (CA1-4 subfields and some granule cells of the dentate gyrus) It inhibits cAMP accumulation and stimulates tyrosine phosphatase activity it also can antiproliferation br GenScript s SST1-expressing stable cell line was made in CHO-K1/Gqi5 host cell and optimized for calcium assays
iQ Biosciences Human Treg Suppression Assay Kit w/ CFSE-Labeled CD8 T Cells
Human Treg functional kits with Regulatory T cells and CD8 T cell responders. CD8 T cells are CFSE-labeled for downstream functional readout. Treg cells are validated for regulatory function. Used to test molecules for modulation of Treg function. Carefully cryopreserved to ensure high viability (> 90%) upon thawing. All orders come with an iQ Certificate of Analysis
Eurofins Discoverx PathHunter CHO-K1 TACR2 β-Arrestin Cell Line, 2 vials. (93-0238C2)
The PathHunter TACR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. substance P) based activation of TACR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TACR2 and EA-tagged β-Arrestin-2. Activation of TACR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.