General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 CXCR6 β-Arrestin Cell Line, 2 vials. (93-0205C2)
The PathHunter CXCR6 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL16) based activation of CXCR6 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR6 and EA-tagged β-Arrestin-2. Activation of CXCR6 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
STEMCELL Technologies Human Peripheral Blood-Derived M0 Macrophages, SF-Cultured, Frozen, Size: 1.5 x 10^6 cells
Primary human cells, frozen
Creative Bioarray Human Skeletal Muscle Microvascular Endothelial Cells, Skeletal Muscle, Endothelial Cell, Cobblestone morphology, 3-5 passages, Negative for mycoplasma, bacteria, yeast, fungi, HIV-1, hepatitis B, C
Human Skeletal Muscle Microvascular Endothelial Cells, Skeletal Muscle, Endothelial Cell, Cobblestone morphology, 3-5 passages, Negative for mycoplasma, bacteria, yeast, fungi, HIV-1, hepatitis B, C
Eurofins Discoverx PathHunter CHO-K1 rGPR120 β-Arrestin Cell Line, 2 vials. (93-1031C2)
The PathHunter rGPR120 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of rGPR120 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rGPR120 and EA-tagged β-Arrestin-2. Activation of rGPR120 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC THP-1; Acute Monocytic Leukemia; Human (Homo sapiens)
THP-1 is a monocyte isolated from peripheral blood from an acute monocytic leukemia patient. This cell line can be used in immune system disorder research, immunology research, and toxicology research. Note: These are suspension cells and floating cells are viable.
Eurofins Discoverx Ready-to-Assay PRP/GPR10 Prolactin-Releasing Peptide Receptor Frozen Cells, 2 Vials of Cells. (HTS057RTA)
The Ready-to-Assay PRP/GPR10 Prolactin-Releasing Peptide Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prolactin releasing peptide) based activation of PRLHR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PRLHR alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of PRLHR, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx HEK 293 HTR2B Gq Cell Line, 2 vials. (95-1024C1)
The HTR2B Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin) based activation of HTR2B GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HTR2B, a naturally Gq coupled GPCR. Upon activation of HTR2B, the resulting calcium activity can be fluorescently assayed using the Calcium No WashPLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Escherichia coli; Strain 2003-3014
Escherichia coli strain 2003-3014 is a whole-genome sequenced strain that was isolated from stool in Michigan. It is toxigenic and was confirmed by PCR to carry the stx1, stx2, and eae genes. This strain is serotype O26:H11 and it has applications for food testing, enteric disease research, and infectious disease research.
ATCC PfizerPneumococcal polysaccharide powder Type 3 (d3) 10mg
Purified pneumococcal polysaccharide type 3 is manufactured by Pfizer, Inc., for small-quantity distribution by ATCC. The pneumococcal powder type 3 is a component of the current 13-valent vaccine against Streptococcus pneumoniae. The pneumococcal polysaccharide type 3 can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
ATCC Bacteroides fragilis
Bacteroides fragilis strain VPI 2553 [EN-2; NCTC 9343] is a type strain that was isolated from an appendix abscess. This whole-genome sequenced strain can be used in media testing, quality control, and pharmaceutical testing.
ATCC Paraclostridium bifermentans; Strain 76
Paraclostridium bifermentans strain 76 is a bacterial anaerobe that is propagated at 37°C.
ATCC L Cells; Fibroblast; Mouse (Mus musculus)
L Cells is a fibroblast cell line that was isolated from the areolar adipose tissue of a 100-day-old, male mouse. It is used to obtain a control conditioned medium for comparison to Wnt-3A or Wnt-5A conditioned medium from L Wnt-3A cells or L Wnt-5A cells. This cell line was deposited by R Nusse.
Eurofins Discoverx PathHunter CHO-K1 ADORA1 β-Arrestin Cell Line, 2 vials. (93-0787C2)
The PathHunter ADORA1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MECA) based activation of ADORA1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged ADORA1 and EA-tagged β-Arrestin-2. Activation of ADORA1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC ART; Ovary Epithelium; Human (Homo sapiens)
ART is a cell line exhibiting epithelial morphology that was derived from an existing ovarian cell line from a 64-year-old female. It can be used to evaluate the infectious entry of polyomaviruses (BKPyV, JCPyV, SV40, MCPyV) and human papillomaviruses. Pathogenic variants of the JCPyV virus previously believed to be non-infectious can infect this cell line.