General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS NMU1R β-Arrestin Cell Line, 2 vials. (93-0232C3)
The PathHunter nMU1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neuromedin U) based activation of nMU1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged nMU1R and EA-tagged β-Arrestin-2. Activation of nMU1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 GPR65 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0428C2A)
The PathHunter GPR65 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR65 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR65 and EA-tagged β-Arrestin-2. Activation of GPR65 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS mCXCR4 β-Arrestin Cell Line, 2 vials. (93-0481C3)
The PathHunter mCXCR4 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL12/SDF-1α) based activation of mCXCR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCXCR4 and EA-tagged β-Arrestin-2. Activation of mCXCR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen NMU1 Neuromedin Receptor Membrane Preparation, 1 vial. (HTS062M)
The ChemiScreen nMU1 Neuromedin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of nMU1R surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen Ghrelin Receptor Membrane Preparation, 1 vial. (HTS187M)
The ChemiScreen Ghrelin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of GHSR surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx PathHunter CHO-K1 NPBWR1 β-Arrestin Cell Line, 2 vials. (93-0818C2)
The PathHunter NPBWR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neuropeptides B/W) based activation of NPBWR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged NPBWR1 and EA-tagged β-Arrestin-2. Activation of NPBWR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ACROBiosystems Human Claudin-9 2Vials
Cell HEK293/Human Claudin-9 Stable Cell Line Claudin-9 Human 2Vials
Eurofins Discoverx PathHunter CHO-K1 mEBI2 β-Arrestin Cell Line, 2 vials. (93-0953C2)
The PathHunter mEBI2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dihydroxycholesterol) based activation of mEBI2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mEBI2 and EA-tagged β-Arrestin-2. Activation of mEBI2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CXCR4 Total Internalization U2OS Cell Line, 2 vials. (93-0890C3)
The PathHunter CXCR4 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CXCR4 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged CXCR4 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CXCR4 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 rOPRM1 β-Arrestin Cell Line, 2 vials. (93-0494C2)
The PathHunter rOPRM1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. DADLE) based activation of rOPRM1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rOPRM1 and EA-tagged β-Arrestin-2. Activation of rOPRM1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.