General Cell Lines and Cell Cultures
Eurofins Discoverx Ready-to-Assay AT1 Angiotensin Receptor Frozen Cells, 2 Vials of Cells. (HTS064RTA)
The Ready-to-Assay AT1 Angiotensin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. Angiotensin-II) based activation of AGTR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AGTR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AGTR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Montana Molecular Human Delta Opioid Receptor (DOR, OPRD, OPRD1) Big Sky BacMam, 15mL
Human Delta Opioid receptor packaged in BacMam for robust expression in mammalian cells. BacMam packaging provides efficient transduction in most cell types - including uniform and near 100% efficiency in HEK293 cells as well as expression in primary or iPSC-derived cells. BacMam expression is easily titrateable to suit your experimental needs.
Eurofins Discoverx ChemiScreen B2 Bradykinin Receptor Stable Cell Line, 2 vials. (HTS041C)
The ChemiScreen B2 Bradykinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bradykinin) based activation of BDKRB2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses BDKRB2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of BDKRB2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Cayman Chemical al-trns RetInal 250mg
A natural retinoid that associates with CRBP-I and CRBP-II (Kds = 50 and 90 nM, respectively), which are involved in the intracellular transport of retinol; an intermediate of the phototransduction pathway of photoreceptors; can form toxic conjugates with proteins and lipids, leading to degeneration of the retina
Eurofins Discoverx ChemiScreen CCR9 Chemokine Receptor Membrane Preparation, 1 vial. (HTS036M)
The ChemiScreen CCR9 Chemokine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CCR9 surface expression. ChemiScreen membrane preps can be used to screen for GPCR activity using GTPγS assays. Increased GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Amsbio LLC Normal Human Normal Human Intr
Normal Human Normal Human Intrahepatic Biliary Epithelial Cells (Cholagioctyes); passage 1
Revvity Health Sciences Inc AequoZen Human Vasopressin V1B Cell Line, CHO-K1 Frozen Cells
AequoZen Human Vasopressin V1B Cell Line, CHO-K1 Frozen Cells
Revvity Health Sciences Inc cAMPZen Frozen Human Adenosine A2B Cell Line, HEK293 Cells
cAMPZen Frozen Human Adenosine A2B Cell Line, HEK293 Cells
Eurofins Discoverx PathHunter CHRM5 Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0657C3)
The PathHunter CHRM5 Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CHRM5 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CHRM5. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CHRM5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Human herpesvirus 1; Strain: F
Human herpesvirus 1 strain F is propagated in HEp-2 cells (ATCC CCL-23). This strain was isolated from the facial vesicle of a human patient and has applications in susceptibility testing and virucide testing.
ATCC Escherichia coli; Strain 2003-3014
Escherichia coli strain 2003-3014 is a whole-genome sequenced strain that was isolated from stool in Michigan. It is toxigenic and was confirmed by PCR to carry the stx1, stx2, and eae genes. This strain is serotype O26:H11 and it has applications for food testing, enteric disease research, and infectious disease research.
ATCC Caki-1; Kidney Carcinoma; Human (Homo sapiens)
Caki-1 is a cell line with epithelial morphology that was isolated from kidney tissue obtained from a 49-year-old, White, male patient with clear cell carcinoma. This cell line is a suitable transfection host and has applications in cancer and toxicology research.
ATCC Escherichia coli; 6 x 0.3mL
Escherichia coli strain Crooks (ATCC 8739-MINI-PACK) consists of 6 ready-to-use vials of ATCC 8739 frozen in 200 μL of glycerol stock, eliminating the need to rehydrate and culture the strain prior to use. Each vial is provided with a 2-D barcode for easy storage and tracking, as well as peel-off labels for fast and reliable recordkeeping.