General Cell Lines and Cell Cultures
Eurofins Discoverx cAMP Hunter CHO-K1 FSHR Gs Cell Line, 2 vials. (95-0119C2)
The cAMP Hunter FSHR Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. FSH) based activation of FSHR GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FSHR, a naturally Gs coupled GPCR. Upon activation of FSHR, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 CHRM4 β-Arrestin Cell Line, 2 vials. (93-0349C2)
The PathHunter CHRM4 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. acetylcholine) based activation of CHRM4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CHRM4 and EA-tagged β-Arrestin-2. Activation of CHRM4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 CRTH2 Gi Cell Line, 2 vials. (95-0072C2)
The cAMP Hunter CRTH2 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of CRTH2 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CRTH2, a naturally Gi/Go coupled GPCR. Upon activation of CRTH2, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Brain: Cerebral Meninges, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
AllCells LLC Mobilized LeukoPak, Fresh, Mozobil(R) 20mg/mL, 1.2mL Single Dose, Full Pak
Mobilized LeukoPak, Fresh, Mozobil(R) 20mg/mL, 1.2mL Single Dose, Full Pak
ATCC Vaginal Epithelial Cell Growth Kit
Vaginal Epithelial Cell Growth Kit contains components that when added to Vaginal Epithelial Cell Basal Medium (ATCC PCS-480-030) create a complete ATCC Primary Cell Solutions culture environment for vaginal epithelial cells derived from normal human vaginal tissue (eg, Primary Vaginal Epithelial Cells, Normal, Human, ATCC PCS-480-010). The serum-free medium formulation can support normal vaginal cell morphology and promote rapid growth and proliferation. No feeder layers, extracellular matrix proteins, or other substrates are required.
Genscript Corporation CHO-K1/ACE2 Stable Cell Line
Recombinant CHO-K1 cells stably express Angiotensin-converting enzyme 2 (ACE2) on the cell surface The surface expression of ACE2 is validated by FACS analysis This stable cell line product is designed for cell-based binding assays that measure binding affinity and stability of antibody based biologics binding with ACE2
Eurofins Discoverx ChemiScreen P2Y4 Purinergic Receptor Stable Cell Line, 2 vials. (HTS211C)
The ChemiScreen P2Y4 Purinergic Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP, UTP) based activation of P2RY4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses P2RY4 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of P2RY4, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PathHunter U2OS INSRa Functional Assay, 2 vials. (93-1008C3)
The PathHunter U2OS INSRa Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated INSRa dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged INSRa and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter HEK 293 IL17RA/IL17RC Dimerization Cell Line, 2 vials. (93-0931C1)
The PathHunter IL17RA/IL17RC Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-17a) induced dimerization of IL17RA/IL17RC receptors. This product uses EFC technology. The cell line included overexpresses IL17RC target protein fused to PK alongside IL17RA target protein fused to EA. Upon ligand-induced dimerization of IL17RA/IL17RC, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
ATCC TransfeX Transfection Reagent
TransfeX Transfection Reagent is a biochemical method for transfection suitable for a number of mammalian cell types. TransfeX Transfection Reagent provides high efficiency with low cell mortality.
ATCC NCI-H1437; Lung Adenocarcinoma; Human (Homo sapiens)
NCI-H1437 [H1437] is a cell line that was isolated from the lungs of a 60-year-old, White male with stage 1 non-small cell lung cancer. This product can be used for cancer research.
ATCC 293; Embryonic Kidney; Human (Homo sapiens)
293 [HEK-293] is a cell line exhibiting epithelial morphology that was isolated from the kidney of a human embryo. This cell line can be used in industrial biotechnology and toxicology research. It has applications in efficacy testing and viruscide testing.
Eurofins Discoverx ChemiScreen SST2 Somatostatin Receptor Stable Cell Line, 2 vials. (HTS028C)
The ChemiScreen SST2 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Biochain Institute Inc Frozen Tissue Section - Human Diabetic Diseased Tissue: Kidney, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.