General Cell Lines and Cell Cultures
Electron Microscopy Sciences Rodent Brain Matrix Adult Ferret, Coronal
RBM allow the investigator to slice either coronal (perpendicular to center line) or sagittal (parallel to center line) sections through the brain at intervals as small as 1mm. All RBM's are identical and durable to insure reproducible sections in the day-to-day, year-to-year, or on a between laboratory basis.
Constructed from high grade zinc to allow for rapid temperature equilibration, easy cleaning, and sterilization. The matrices are designed to accommodate the brains of rodents placed ventral side up. The channels are precisely cut at 1 mm intervals and 0.3 mm wide.
Type: Coronal
Eurofins Discoverx PathHunter CCKBR Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0708C3)
The PathHunter CCKBR Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of CCKBR via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CCKBR. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CCKBR-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS GHR-JAK2 Functional Assay, 2 vials. (93-0829C3)
The PathHunter GHR-JAK2 Functional assay cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting CTKs. This cell line enables assessment of GHR activation via detection of JAK2 mediated phosphorylation-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged GHR cytokine receptor, an untagged CTK JAK2 and EA-tagged SH2 domain protein. Upon activation of the cytokine receptor, CTK-based receptor phosphorylation leads to SH2-EA recruitment and production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter U2OS GPBAR1 β-Arrestin Cell Line, 2 vials. (93-0794C3)
The PathHunter GPBAR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bile acids) based activation of GPBAR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPBAR1 and EA-tagged β-Arrestin-2. Activation of GPBAR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 SCTR β-Arrestin Cell Line, 2 vials. (93-0237C2)
The PathHunter SCTR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. secretin) based activation of SCTR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged SCTR and EA-tagged β-Arrestin-2. Activation of SCTR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Listeria innocua
Listeria innocua strain SLCC 3379 is a whole-genome sequenced bacterial type strain that was isolated from a cow brain. This strain can be used in quality control testing or as an indicator strain in the CAMP test.
Eurofins Discoverx PathHunter CHO-K1 PTAFR β-Arrestin Cell Line, 2 vials. (93-0236C2)
The PathHunter PTAFR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAF) based activation of PTAFR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PTAFR and EA-tagged β-Arrestin-2. Activation of PTAFR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 GPR6 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0634C2)
The PathHunter GPR6 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR6 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR6 and EA-tagged β-Arrestin-2. Activation of GPR6 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.