General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen CGRP1 Calcitonin Receptor-Like Receptor Stable Cell Line, 2 vials. (HTS172C)
The ChemiScreen CGRP1 Calcitonin Receptor-Like Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. calcitonin) based activation of CALCRL - RAMP1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CALCRL alongside RAMP1 modifying protein and endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CALCRL, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Listeria monocytogenes; Strain: CFSAN000778
Listeria monocytogenes strain CFSAN000778 was isolated in 2011 from a food production environment. It is typed as serotype 1/2a and has applications in enteric, infectious, and zoonotic disease research.
Biochain Institute Inc Multiple Tumor Tissue Array - 7 different normal tissues and 5 major tumor types in duplicates for IHC antibody and ISH, 5 slides/PK
BioChain's tissue arrays or tissue microarrays (TMAs) are a useful tool in biomarker research and drug target validation. It consists of paraffin blocks that are assembled in array fashion to allow multiplex histological analysis. BioChain's TMAs provide a valuable tool for analysis of protein, RNA, or DNA molecules in oncology, both the malignant and metastatic markers. TMAs can also be constructed with tissues from other diseases and species.
Eurofins Discoverx Ready-to-Assay GAL1 Galanin Receptor Frozen Cells, 2 Vials of Cells. (HTS094RTA)
The Ready-to-Assay GAL1 Galanin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. galanin) based activation of GALR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GALR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of GALR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Escherichia coli; Quantitative DNA
Quantitative Genomic DNA from Escherichia coli strain 2002-3211 can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
Eurofins Discoverx ChemiScreen CRF2 Neuropeptide Receptor Membrane Preparation, 1 vial. (HTS024M)
The ChemiScreen CRF2 Neuropeptide Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CRHR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Lonza Walkersville KBM Keratinocyte Basal Medium
KBM Keratinocyte Basal Medium Calcium Free is a keratinocyte basal medium sold separately It can be used with 1 kit of CC-4131 (keratinocyte cell growth medium SingleQuotsTM Supplements and Growth Factors) The full KGMTM Calcium Free BulletKitTM consisting of basal medium and supplements can be purchased together using the catalog number CC-3112 KGMTM Keratinocyte Growth Medium Calcium Free has been optimized for the proliferation of keratinocytes in a serum-free and calcium-free environment Keratinocytes cannot survive in a completely calcium free system
Eurofins Discoverx cAMP Hunter CHO-K1 HTR1A Gi Cell Line, 2 vials. (95-0132C2)
The cAMP Hunter HTR1A Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serotonin/5-HT) based activation of HTR1A GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type HTR1A, a naturally Gi/Go coupled GPCR. Upon activation of HTR1A, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Parietal Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Lonza Walkersville Mouse Brain CD1 Hippoc Neurons
Clonetics Mouse Hippopcampal Neurons are isolated from E16-17 CD-1 mice The hippocampus is a major component of the brains of humans and other mammals It belongs to the limbic system and plays important roles in long-term memory and spatial navigation Clonetics Mouse Hippocampal Neurons are cryopreserved at primary passage They stain positive for PGP and Tuj-1 and test negative for sterility and mycoplasma Cells are guaranteed when using Clonetics PNGM media and contain 1M cells per vial Recommended medium PNGM BulletKit (CC-4461)
Lonza Walkersville ADSC - Suppl Growth Factors
Stem cells possess the unique ability to proliferate as an undifferentiated cell type then when properly stimulated differentiate into multiple lineages of cells Lonza s ADSC human Adipose Derived Stem Cell Growth BulletKit Medium is a serum containing medium designed to proliferate human adipose derived mesenchymal stem cells (both normal and diseased) in an undifferentiated state The serum used in Lonza s ADSC human Adipose Derived Stem Cell Growth BulletKit Medium is specifically screened to ensure that the serum neither promotes spontaneous differentiation of cells nor inhibits cell differentiation to osteogenic chondrogenic or adipogenic lineages (when properly stimulated with an appropriate differentiation media)
Lonza Walkersville D-Hu Subcut Preadipo Diabet I
Poietics Diseased Human Preadipocytes (D-HprAD) are isolated from subcutaneous or visceral fat from diabetic Type I and diabetic Type II donors Preadipocytes from normal (non-diabetic) donors are available as a separate product Pertinent additional donor information including Body Mass Index (BMI) insulin dependence and age of diagnosis may be available by contacting Scientific Support Cryopreserved Poietics Diseased Human Preadipocytes (D-HprAD) are guaranteed to contain 1 million cells per ampoule and test positive for adipogenic differentiation All cells test negative for mycoplasma bacteria yeast and fungi HIV-1 hepatitis B and hepatitis C are not detected for all donors and/or cell lots A Certificate of Analysis is provided for each cell lot purchased
World Precision Instrument AutoLCI Adapter for T-Flask 75 cm2, Single
With EVOM™ AutoLCI, cells cultured in different vessel types can be imaged. Interchangeable vessel adapters can accommodate various vessel types including well-plate, culture flask, and culture dish. The system includes a well-plate adapter, but you can buy separately different adapters for a variety of vessels used.
ATCC Streptomyces albus (80614)
Produces salinomycin, salbostatin, and epi-17-deoxy (0-8)-salinomycin. This material is cited in a U.S. and/or other Patent and may not be used to infringe the patent claims.