Sera
Cayman Chemical BromadIolon 100mg
A second generation anticoagulant rodenticide; an inhibitor of VKOR that inhibits blood clotting; inhibits human VKORC1 (IC50 = 1.6 nM); toxic to rodents, including mice (LD50 = 1.75 mg/kg) and rats (LD50s = 1.05 and 1.83 mg/kg for males and females, respectively); does not significantly affect breeding performance in mice at 70% of the LD50 value
Cayman Chemical DLRythroPDMPhydroCLOrId 100mg
A PDMP mixture containing D-erythro (1S,2R) PDMP and L-erythro (1R,2S) PDMP; protects GlcCer synthase from degradation and increases ceramide levels in MDCK cells at 40 µM; inhibits UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes at 100 µM; inhibits the growth of isolated rabbit skin fibroblasts at 50 µM but is cytotoxic at >50 µM
Cayman Chemical N4-MethylcytIdIn 100mg
A pyrimidine nucleoside and derivative of cytidine; found in mammalian mitochondrial rRNA where it stabilizes the structure of 12S rRNA and is essential for mitochondrial translation of oxidative phosphorylation-related proteins; maintains normal base pairing with guanine in RNA oligomers
Cayman Chemical 4deoxy PyrIdoxInhydroCLO 100mg
A vitamin B6 antimetabolite; inhibits transport of pyridoxine, pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells; inhibits S1P lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells; decreases latency to first seizure in mice (ED50 = 1 mmol/kg) and increases the occurrence and duration of myoclonic responses in baboons with photosensitive epilepsy; reduces TNF-α and IL-6 production in mice infected with T. spiralis
Cayman Chemical SpIraprIlhydrochlorIde 50mg
An ACE inhibitor (IC50 = 67 nM) and a prodrug form of spiraprilat; inhibits the angiotensin I-induced pressor response in rats and dogs (ID50s = 16 and 262 UG/kg, respectively); decreases systolic blood pressure and left ventricular hypertrophy and induces angiogenesis in spontaneously hypertensive rats 5 mg/kg
Cayman Chemical DOIhydrochlorIde 50mg
An analytical reference standard categorized as an amphetamine and phenethylamine; has psychotomimetic properties and abuse has been reported; intended for research and forensic applications
Cayman Chemical TrndolaprIl 100mg
A prodrug form of trandolaprilat; inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 13.1 and 21.1 μg/kg, respectively); potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg); decreases systolic and diastolic arterial pressure in dogs at 0.1, 0.3, and 1 mg/kg; decreases MAP and LVEDP in a rat model of left coronary artery occlusion-induced heart failure at 3 mg/kg; increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet
Cayman Chemical PAMAM DndrImR G6 0 AMDoth 50mg
A hydroxyl-terminated PAMAM dendrimer; ~65 Å in diameter in PBS; induces mortality in zebrafish embryos to a lesser extent than PAMAM dendrimer G6.0 amine but to a greater extent than PAMAM dendrimer G6.0 succinamic acid at 250 ppm in the tank water
Cayman Chemical PnobInostat 50mg
A pan-HDAC inhibitor (Kis = 0.6-31 nM for HDAC1-11); inhibits growth in a panel of 37 human or mouse lung cancer cell lines, including SCLC, NSCLC, and mesothelioma cells (IC50s = 4-175, 5-310, and 5-470 nM, respectively); induces tumor regression in BK-T and RG-1 SCLC mouse xenograft models at 20 mg/kg i.p.
Innovative Research Inc Single Donor Human Pregnancy Serum Off The Clot First Trimester 1ml
Single Donor Human Pregnancy Serum Off The Clot from Innovative Research is collected from a pregnant female at an FDA-Licensed facility within the United States. Samples are available as non-pooled 1 ml aliquots from individual cases.
Cayman Chemical TemocaprIlhydrochlorIde 50mg
A prodrug form of temocaprilat; prevents impairment of acetylcholine-induced relaxation in aortic rings isolated from diabetic rats in a model of streptozotocin-induced diabetes; inhibits the angiotensin I-induced pressor response in normotensive rats at 0.1, 0.3, and 1 mg/kg; prevents coronary vascular remodeling induced by L-NAME in rats at 0.1 mg/ml in the drinking water; reduces plasma glucose levels in a KKAy mouse model of type 2 diabetes at 1 mg/kg
Cayman Chemical R-Lnsoprazole 100mg
A pure enantiomer of lansoprazole that inhibits acid formation in isolated canine parietal cells with an IC50 value of 59 nM and inhibits the H+/K+-ATPase with an IC50 value of 4.2 µM
Cayman Chemical 2-ImInobIotInhydrobromIde 50mg
A guanidine-modified biotin derivative and an inhibitor of iNOS and nNOS (Kis = 21.8 and 37.5 µM for the mouse and rat enzymes, respectively); prevents hypoxia-ischemia-induced decreases in brain phosphocreatine and ATP levels and increases in edema in the parietal cortex and striatum, as well as reduces apoptosis in the parietal- and temporal cortex and striatum, in piglets at 0.2 mg/kg every four hours; increases survival of, and decreases electrographic seizures in, hypoxia-ischemia-injured piglets at 0.2 and 1 mg/kg every four hours; LNPs containing 2-iminobiotin conjugated to poly-L-lysine have been used to improve LNP tumor targeting, uptake, and retention compared with LNPs containing biotin conjugated to poly-L-lysine in rats
Cayman Chemical DnofloxacInmesylate 100mg
A fluroquinolone antibiotic; has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry (MICs = 8-500 nM); protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of 0.31, 0.40, and 2.42 mg/kg, respectively
