Mouse Secondary Antibodies
Biotium Cyclin B1 (G2- & M-phase Cyclin)(CCNB1/2978R), CF568 conjugate, 0.1mg/mL
Recognizes a protein of 55-62 kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF4
Biotium Primary Antibody gp100 Pmel17 SILV HMB45 CF740 1/EA
By immunohistochemistry this antibody specifically recognizes a protein in melanocytes and melanomas It reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes Intradermal nevi normal adult melanocytes and non-melanocytic cells are negative It does not stain tumor cells of epithelial lymphoid glial or mesenchymal origin Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas large cell lymphomas and sarcomas using H and E stains alone It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms This MAb stains fetal and neonatal melanocytes junctional and blue nevus cells malignant melanoma and angiomyolipoma (PEComa) Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M are not
Biotium Primary Antibody CHGA Chromogranin A PHE5 CF740 1/EA
Chromogranin A is present in neuroendocrine cells throughout the body including the neuroendocrine cells of the large and small intestine adrenal medulla and pancreatic islets It is an excellent marker for carcinoid tumors pheochromocytomas paragangliomas and other neuroendocrine tumors Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms Reportedly co-expression of certain keratins and chromogranin indicates neuroendocrine lineage The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms Most pituitary adenomas and prolactinomas readily express chromogranin Primary antibodies are available purified or with a selection of fluorescent CF Dyes and other labels CF Dyes offer exceptional brightness and photostability Note Conjugates of blue fluorescent dyes like CF405S and CF405M are
Biotium DOG-1(DG1/447), CF740 conjugate, 0.1mg/mL
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give hig
Biotang Inc MUS ANTI HUM; Leukocyte-Associated Ig-Like Receptor 1
MUS ANTI HUM; Leukocyte-Associated Ig-Like Receptor 1
Biotang Inc MUS ANTI HUM; Triggering receptor expressed on myeloid cells 2
MUS ANTI HUM; Triggering receptor expressed on myeloid cells 2
Biotium GLUT-1 (Tumor Progression and Mesothelioma Marker)(GLUT1/3132R), 0.2mg/mL
Recognizes a protein of 55 kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative). Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightnes
Biotium Sarcomeric Actinin Alpha 2 / ACTN2(ACTN2/3291), 0.2mg/mL
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue flu
Genscript Corporation LIGHT Human
LIGHT also known as tumor-necrosis factor (TNF) superfamily member 14 (TNFSF14) is predominantly expressed on activated immune cells and some tumor cells LIGHT (homologous to lymphotoxin exhibits inducible expression and competes with Herpes Simplex Virus glycoprotein D for Herpes Virus Entry Mediator a receptor expressed by T cells) is a protein primarily expressed on activated T cells activated Natural Killer (NK) cells and immature dendritic cells (DC) LIGHT can function as both a soluble and cell surface-bound type II membrane protein and must be in its homotrimeric form to interact with its two primary functional receptors Herpes Virus Entry Mediator (HVEM) and Lymphotoxin- Receptor (LT R) LIGHT signaling through these receptors have distinct functions that are cell-type dependent but interactions with both types of receptors have immune-related implications in tumor biology
Biotang Inc Geminin, Mouse Anti Human, GMNN Antibody, Mouse Anti Human Monoclonal.
Geminin, Mouse Anti Human, GMNN Antibody, Mouse Anti Human Monoclonal.