Mouse Secondary Antibodies
Biotium Histone H1 (Pan Nuclear Marker)(AE-4), CF740 conjugate, 0.1mg/mL
Please note that this antibody is a recombinant Rabbit version of original anti-histone H1 antibody (Clone AE-4). Because the variable heavy (VH) and variable light (VL) domains are the same, recombinant antibody has the same exact reactivity as the original AE-4 MAb. There are several advantages of producing a recombinant version of a monoclonal antibody. For example, a recombinant antibody is a pure preparation of active immunoglobulin with no contaminating non-functional intact Ig or free light/heavy chains. Secondly, antibody can always be produced, even if hybridoma line is lost. Moreover, it adds the flexibility of converting the antibody to any species, isotype or format. Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the
Biotium CD47 / IAP (Integrin Associated Protein)(CD47/2937), CF568 conjugate, 0.1mg/mL
This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Genscript Corporation CD40/TNFRSF5 His Mouse
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects CD40 molecule is a potential target for cancer immunotherapy There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells
ABclonal Technology Mouse anti MBP-Tag mAb
Maltose-Binding Protein (MBP) is a part of the maltose/maltodextrin system of Escherichia coli, which is responsible for the uptake and efficient catabolism of maltodextrins. It is a complex regulatory and transport system involving many proteins and protein complexes. MBP has an approximate molecular mass of 42.5 kilodaltons.
ABclonal Technology Mouse anti GFP-Tag mAb
Green fluorescent protein (GFP) is a 238-amino acid protein (26.9 kDa) that fluoresces green when exposed to blue or UV light. It was first isolated from the jellyfish Aequorea victoria. GFP has a major excitation peak at 395 nm and an emission peak at 509 nm, in the green portion of the visible spectrum. It is widely used in biology due to its ability to form a chromophore without needing cofactors or enzymes. GFP is commonly used as a reporter gene in molecular biology and has been modified to create biosensors. It has been expressed in various species, including bacteria, yeasts, fungi, fish, and mammals, demonstrating its utility for tracking gene expression in living organisms and cells. GFP can be introduced into species through transgenic techniques and passed down through generations.
ABclonal Technology Mouse anti Trx-Tag mAb
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at the four-cell stage of the developing embryo. Although not entirely understood, thioredoxin plays a central role in humans and is increasingly linked to medicine through their response to reactive oxygen species (ROS). In plants, thioredoxins regulate a spectrum of critical functions, ranging from photosynthesis to growth, flowering and the development and germination of seeds. It has also recently been found to play a role in cell-to-cell communication.
Sino Biological Recombinant Mouse IL-17F Protein
A DNA sequence encoding the Mouse IL17F (NP_665855.2) (Arg29-Ala161) was expressed with an initial Met.
Biotium CD59 (heavy chain of Protectin)(BRA-10G), CF488A conjugate, 0.1mg/mL
Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb is useful for study on GPI-anchored proteins, PNH and CD59 functions.Primary antibodies are available purified,
Genscript Corporation cTnI 6D11 mAb Mouse
Cardiac Troponin I (cTnI) is synthesized in cardiac muscle and forms a structural complex with Troponin T and C Its concentration in blood increases after the onset of chest pain and maintains peak for a couple of weeks The cTnI protein is considered as useful diagnosis marker for acute myocardial infarction (AMI)
AdipoGen IgG mouse pAb HRP
Polyclonal Antibody. Reacts with mouse IgG1, IgG2a, IgG2b and IgG3. Source Goat. Applications IHC, WB. Liquid. In PBS containing 50% glycerol. The anti-IgG mouse, pAb HRP is cross-absorbed against mouse IgM and IgA, pooled human sera and purified human paraproteins and affinity-purified on pooled mouse IgG covalently linked to agarose.
Cayman Chemical L-a-Methyldopa 25g
A DOPA decarboxylase inhibitor (ED50 = 21.8 mg/kg); α2-adrenergic receptor agonist; metabolized to α-methylnorepinephrine in the CNS; has antihypertensive activity in vitro and in vivo; improves trophoblast and endothelial cellular interaction in vitro
Cayman Chemical CIlIobrevIn A 10mg
A hedgehog pathway inhibitor that blocks Shh-induced hedgehog pathway activation (IC50 = 7 µM); inhibits primary cilia formation; inhibits dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic AAA+ family; inhibits mTORC1 activity in uninfected and HCMV-infected cells