Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human TLR3 mAb
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity TLRs are highly conserved from Drosophila to humans and share structural and functional similarities They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity The various TLRs exhibit different patterns of expression This receptor is most abundantly expressed in placenta and pancreas and is restricted to the dendritic subpopulation of the leukocytes It recognizes dsRNA associated with viral infection and induces the activation of NF-kappaB and the production of type I interferons It thus plays a role in host defense against multiple viruses
Jackson Immuno Research Labs Cy3-AffiniPure Rabbit Anti-Human IgG (H+L) (min X Ms Sr Prot)
Cy3-AffiniPure Rabbit Anti-Human IgG (H+L) (min X Ms Sr Prot)
ABclonal Technology 555 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology PE Rabbit anti-Human CD8b mAb
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 beta chain isoforms Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described A pseudogene also located on chromosome 2 has been identified
ABclonal Technology 647 Rabbit anti-Human CD33
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology PE Rabbit anti-Human TIGIT mAb
This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH) The protein has been shown to bind PVR with high affinity this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses
ABclonal Technology 488 Rabbit anti-Human TROP-2
This intronless gene encodes a carcinoma-associated antigen This antigen is a cell surface receptor that transduces calcium signals Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy
ABclonal Technology APC Rabbit anti-Human CD5 mAb
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes T lymphocytes and a subset of B lymphocytes The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation Alternative splicing results in multiple transcript variants encoding different isoforms
Jackson Immuno Research Labs AMCA-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgM Fc5µ Fragment Specific
AMCA-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgM Fc5µ Fragment Specific