Rabbit Secondary Antibodies
ABclonal Technology SFT Rabbit mAb
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation Ubiquitination involves at least three classes of enzymes ubiquitin-activating enzymes or E1s ubiquitin-conjugating enzymes or E2s and ubiquitin-protein ligases or E3s This gene encodes a member of the E2 ubiquitin-conjugating enzyme family This enzyme is closely related to a stimulator of iron transport (SFT) and is up-regulated in hereditary hemochromatosis It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology KPNA6 Rabbit mAb
Nucleocytoplasmic transport a signal- and energy-dependent process takes place through nuclear pore complexes embedded in the nuclear envelope The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor a heterodimer of importin alpha and beta subunits also known as karyopherins Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex In the presence of nucleoside triphosphates and the small GTP binding protein Ran the complex moves into the nuclear pore complex and the importin subunits dissociate Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore The protein encoded by this gene is a member of the importin alpha family
Abcam Rabbit Anti Cow Igg Hl Fitc AB102148-1MG
Rabbit Anti Cow Igg Hl Fitc AB102148-1MG
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology HSP40 Rabbit mAb
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins DNAJ family members are characterized by a highly conserved amino acid stretch called the J-domain and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events such as protein folding and oligomeric protein complex assembly The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation Alternative splicing results in multiple transcript variants
ABclonal Technology RPGR Rabbit mAb
This gene encodes a protein with a series of six RCC1-like domains (RLDs) characteristic of the highly conserved guanine nucleotide exchange factors The encoded protein is found in the Golgi body and interacts with RPGRIP1 This protein localizes to the outer segment of rod photoreceptors and is essential for their viability Mutations in this gene have been associated with X-linked retinitis pigmentosa (XLRP) Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported but the full-length natures of only some have been determined
ABclonal Technology TdT Rabbit mAb
This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3 -hydroxyl terminus of oligonucleotide primers In vivo the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments Alternatively spliced transcript variants encoding different isoforms of this gene have been described
Biotium CD33(C33/69), CF594 conjugate, 0.1mg/mL
Recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluor
Cayman Chemical CXADR RabbIt MoncLNal ntIb 1mL
Immunogen: Recombinant human CXADR8 • Host: Rabbit • Species Reactivity: (+) Human • Cross Reactivity: (+) CXADR • Applications: ELISA, FC, ICC, IF
ABclonal Technology AKT3 Rabbit mAb
The protein encoded by this gene is a member of the AKT also called PKB serine threonine protein kinase family AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors They are involved in a wide variety of biological processes including cell proliferation differentiation apoptosis tumorigenesis as well as glycogen synthesis and glucose uptake This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF) insulin and insulin-like growth factor 1 (IGF1) Alternatively splice transcript variants encoding distinct isoforms have been described
ABclonal Technology EPHA2 Rabbit mAb
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family EPH and EPH-related receptors have been implicated in mediating developmental events particularly in the nervous system Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands This gene encodes a protein that binds ephrin-A ligands Mutations in this gene are the cause of certain genetically-related cataract disorders
Cayman Chemical HDAC3CTerm RabbIt Monclo 100uL
A flavonoid inhibits Cav3 2 and high-voltage-activated calcium currents in whole-cell patch-clamp assays using HEK293 cells (IC50s 0 912 and 4 765 UM respectively) reduces the activity of ALR2 (IC50 6 2 UM for the recombinant human enzyme) inhibits proliferation of PC3 and DU145 prostate cancer cells (IC50s 18 4 and 29 1 UM respectively) reduces mechanical allodynia in a mouse model of neuropathic pain induced by partial sciatic nerve ligation at 20 and 30 mg/kg
ABclonal Technology HRPT2 / CDC73 Rabbit mAb
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways The protein is a component of the the PAF protein complex which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex This protein appears to facilitate the association of 3 mRNA processing factors with actively-transcribed chromatin Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome familial isolated hyperparathyroidism and parathyroid carcinoma
CPC Scientific (Z-Phe-Arg)2-R110 (hydrochloride salt) 25MG
Plasmin, Cathepsin L.ONE-LETTER SEQUENCE: (Z-FR)2-R110MOLECULAR FORMULA: C66H68N12O11MOLECULAR WEIGHT:1205.32 (HCl salt not included in MW)STORAGE CONDITIONS: -20 5CRESEARCH AREA: ApoptosisREFERENCES: Biol Chem Hoppe-Seyler 373, 433 (1992); Nature 361, 274 (1993)
